Báo cáo y học: "Decreased effector memory CD45RA+CD62L– CD8+ T cells and increased central memory CD45RA–CD62L+ CD8+ T cells in peripheral blood of rheumatoid arthritis patients" ppt
Báo cáo y học: "Decreased effector memory CD45RA+CD62L– CD8+ T cells and increased central memory CD45RA–CD62L+ CD8+ T cells in peripheral blood of rheumatoid arthritis patients" ppt
... suggested, the precisenature of their involvement is not fully understood. In thepresent study we examined the central and effector memory phenotypes of CD4+ and CD8+ T cells in the peripheral ... phenotype, and the significance was not known at that time.Our finding that peripheral blood CD8+ T cells exhibit increased central memory phenotype and decreased ter-minally differentiated effector ... role in thepathogenesis of RA by generating effector cells that cancontribute to the synovial inflammation of RA.Patients and methodsPatients Peripheral blood was obtained from patients with...
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Báo cáo y học: "Are bone erosions detected by magnetic resonance imaging and ultrasonography true erosions? A comparison with computed tomography in rheumatoid arthritis metacarpophalangeal joints" pptx
... method in order to determine the sensitivity, specificity and accuracy of MRI, US and radiography in detecting bone erosions in RAMCP joints.Materials and methodsPatients and control individualsSeventeen ... directly transferable to other patientcohorts. The moderate sensitivity of MRI found in this studysuggests that the applied OMERACT RAMRIS definition of erosions [30] does not overestimate the ... purposes)that the present study further supports the future use of theOMERACT RAMRIS definition of bone erosion.Overall, the sensitivity of US in detecting bone erosions in thepresent study was...
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Báo cáo y học: "Decreased response to IL-12 and IL-18 of peripheral blood cells in rheumatoid arthritis" doc
... Kawashima M, Taniai M, Yamauchi H, Tanimoto T, Kurimoto M, Morita Y, Ohmoto Y, Makino H: Interferon-gamma-inducing activity of interleukin-18 in the joint with rheumatoid arthritis. Arthritis Rheum ... : Th1 cytokine balance in blood, was higher in RApatients. These findings suggest that in RA the Th1 : Th2ratio in the blood and that in the synovium are different.Accumulation of Th2 vs Th1 ... presence of IL-12as a contributory factor in inducing the IFN-γ-dominant T- cell cytokine response in joints of patients with long-standing RA [13]. IL-18 is a proinflammatory cytokine thatplays...
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Báo cáo y học: "Decreased levels of soluble amyloid β-protein precursor and β-amyloid protein in cerebrospinal fluid of patients with systemic lupus erythematosus" ppsx
... in theCSF of SLE patients with and without CNS involvement, and to assess these data prospectively with respect toimmunosuppressive treatment. Our results indicate thatthe SLE patients studied ... brain pathology. Thisfinding, together with increased intrathecal levels of TGF-β, indicates an ongoing destructive parenchymatousprocess in the SLE brain. In addition, the present study provides ... of APP or the activity of secretases. Indeed, it has been recently demonstrated thatanti-inflammatory drugs may directly modulate γ-secretaseactivity and thereby decrease Aβ42 production [41].We...
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Báo cáo y học: "Decreased metalloproteinase production as a response to mechanical pressure in human cartilage: a mechanism for homeostatic regulatio" pps
... possibility is that OA chondrocytes may beless sensitive to loading response. Lastly, other inflammatoryfactors may act on chondrocytes mainly as stimuli hiding theload effect. This loss of regulation ... to type IIcollagen found in the matrix cartilage areas according to load-bearing capacity suggest that the balance between the majorstructural proteins seems to be crucial to the integrity ... Ourresults have not shown a direct relationship between the per-centage of apoptotic chondrocytes and the areas of maximal and minimal load of the coxofemoral joint.Competing interestsThe authors...
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Báo cáo y học: "Decreased levels of the gelsolin plasma isoform in patients with rheumatoid arthritis" docx
... were detected in SFs of 77 of the 81RA patients and in plasmas of 19 of the 78 patients by immu-noblotting (Figure 4a). In addition, very low concentrations of actin were detected in 2 of the ... spaceor other affected organs in order to maintain a steady-stateconcentration at the site of inflammation. pGSN has the poten-tial to interact with several macromolecules present at sites of inflammatory ... concentrations in combination with the presence of actin and gelsolin-actincomplexes in synovial fluids suggest a local consumption of thispotentially anti-inflammatory protein in the inflamed...
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Báo cáo y học: "Imbalanced effector and regulatory cytokine responses may underlie mycobacterial immune restoration disease" pot
... that presents later [8-10].Immunity to mycobacterial infections is influenced by thecounteracting effects of effector cytokines and regulatorycytokines, such as interleukin (IL)-10, in patients ... Ottenhoff TH: Dynamic changes in pro- and anti-inflammatory cytokine profiles and gamma interferonreceptor signaling integrity correlate with tuberculosis dis-ease activity and response to ... delayed-type hypersensitivity (DTH)response to mycobacterial antigens is a characteristic find-ing [1,5,6], and coincides with excessive production of Type 1 (Th1) cytokines [7], probably by memory...
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Báo cáo y học: "Decreased GABAB receptor function in the cerebellum and brain stem of hypoxic neonatal rats: Role of glucose, oxygen and epinephrine resuscitation" pot
... conceived of the study and participated in its design and coordination. All authors read and approvedthe final manuscript.Competing interestsThe authors declare that they have no competing interests.Received: ... at initia-tion of resuscitation continues in the international com-munity. The present study focused on understandingthe alterations in GABA content, total GABA and GABABreceptors and GAD ... postnatal day 4includes many of the neurodevelo pmental events thatmay be affected by hypoxia in preterm human infants. In the pre sent study, we investigated the functional reg-ulation of...
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Báo cáo y học: "Relationships between free radical levels during carotid endarterectomy and markers of arteriosclerotic disease"
... catalytically active, both in vitro and in vivo. The activity of MMPs is increased by gene transcription, extracellular activation of the secreted inactive zymogen form, and reduced activity of ... needle inserted into the inter-nal carotid artery distal to the stenotic lesion. A shunt was not considered necessary in any case. After clamping the internal carotid artery, the internal and ... peroxidation. Pre-treatment of the patients with a xanthine oxidase inhibitor influences radical production, indicating that oxidation of accumulated hypoxanthine has a role to play in this...
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Tài liệu Báo cáo Y học: Transactivation domains are not functionally conserved between vertebrate and invertebrate serum response factors potx
... results obtained indicateco-immunoprecipitation and, therefore, interaction betweenFig. 1. Effect of SRF co-expression on the activity of CArG-containing promoters. (A) Activity of CArG-containing ... given to each construct is indicated to the right (N1 to N7, C1 and M). Numbers to the left indicate the N-terminal amino acid encoded by each construct. Constructs C1 and M terminated translation ... C show the activity obtained without any SRFco-expression, that was given the value 100. Asterisks indicate statistically significant differences in relation with the activity obtained after full-length...
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