Báo cáo y học: "Gene profiling for defining targets for new therapeutics in autoimmune diseases" potx
Báo cáo y học: "Gene profiling for defining targets for new therapeutics in autoimmune diseases" potx
... lymphocytes
Review
Gene profiling for defining targets for new therapeutics in
autoimmune diseases
Lars Rogge
Immunoregulation Laboratory, Department of Immunology, Institut Pasteur, Paris, France
Corresponding ... level in type 1 cells while TRAF5
was preferentially expressed in type 2 cells. Members of
this family serve as adapter proteins that mediate cytokine
signali...
Báo cáo y học: "Gene profiling in white blood cells predicts infliximab responsiveness in rheumatoid arthritis" potx
... profiles in rheumatoid fibroblast-like
synoviocytes induced by the proinflammatory cytokines inter-
leukin-1 beta and tumour necrosis factor. Inflamm Res 2005,
54:10-16.
42. Zhou A, Scoggin S, Gaynor ... Membrane-type 1 matrix metalloprotein
cytoplasmic tail binding protein 1
MTCBP-1 2p25.2 -2.04 0.005
148134 RP1-29K1 containing KiAA0426 NS0.002
127203 CytP450, family 4, subfamily F, polyp...
Báo cáo y học: "Gene expression and activity of cartilage degrading glycosidases in human rheumatoid arthritis and osteoarthritis synovial fibroblast" potx
... MMPs,
proinflammatory cytokines and chemokines [13].
There is increasing evidence that SFs are key players in the
pathogenesis of RA by invading and eroding hyaline cartilage.
SFs, activated locally, ... efficient in
degrading hyaline cartilage directly [5]. The measured NAG
activity is characteristic for hexosaminidase, the enzyme
responsible for the hydrolysis of terminal nonreducin...
Báo cáo y học: "Celecoxib accelerates functional recovery after sciatic nerve crush in the rat" potx
... prostaglandins in the patho-
genesis of neuropathic pain. Eur J Neurosci 2002, 15(6):1037-47.
8. Ma W, Eisenach JC: Cyclooxygenase 2 in infiltrating inflamma-
tory cells in injured nerve is universally ... is
strongly upregulated around the injury site, possibly playing a role in the regulation of the
inflammatory response. In this study we investigated the effect of celecoxib, a CO...
Báo cáo Y học: Identification and characterization of a new gene from Variovorax paradoxus Iso1 encoding N -acyl-D-amino acid amidohydrolase responsible for D-amino acid production pdf
... oxidation in proteins are
histidine, lysine, proline, cysteine, arginine and methionine
residues [52]. Methionine oxidation can be caused by
protein damage or aging by endogenous or oxidizing agents
[53,54] ... N-acetyl-
D
-alanine,
N-acetyl-
D
-leucine and N-chloroacetyl-
D
-phenylalanine
than towards N-acetyl-
D
-valine, N-acetyl-
D
-phenylalanine,
N-acetyl-
D
-tryptophan, N-acetyl-
D
-ty...
Báo cáo y học: "Gene expression signatures for autoimmune disease in peripheral blood mononuclear cells" potx
... approach
were largely in oncology, many new reports are emerging in other fields including infectious diseases
and pharmacology, and applications in autoimmunity have been recently reported by our group ... reasonably obtained.
Surprisingly, information about the amount of blood
needed to produce an analyzable sample has not been
uniformly reported; one group used lymphocytopheresis,...
Báo cáo y học: " Gene therapy in animal models of rheumatoid arthritis: are we ready for the patients" pdf
... of
proinflammatory and anti-inflammatory cytokines than
found in serum; furthermore, the levels reflected disease
activity [105]. Spillover of cytokines or inhibitors to the
draining lymphatic system ... genetically modified cells into the
inflamed joint. Autografts of human IL-1Ra-expressing
synoviocytes protect against leucocytosis, synovitis and
cartilage proteoglycan loss, which are ind...
Báo cáo y học: "Autoantibody profiling for the study and treatment of autoimmune disease" docx
... cells
Protein arrays of living Robotic delivery of yeast transformants Colorimetric 6000 Performed in Arrays of yeast expressing fusion [10]
transformants; modified expressing yeast open reading frames ... protein,
myelin-associated glycoprotein, myelin oligodendrocytic
glycoprotein, golli-myelin basic protein, oligodendrocyte-
specific protein, cyclic nucleotide phosphodiesterase and
overl...
Báo cáo y học: "Gene expression profiling in murine autoimmune arthritis during the initiation and progression of joint inflammation" pps
... donor lymphocytes, only very
few cells were found in joints during the first week of
transfer, and a second cell transfer was needed to induce
a significant influx of lymphocytes into the joints ... severe combined immunodeficient mice by using
adoptive transfer of lymphocytes from proteoglycan-immunized
arthritic BALB/c mice. In this unique system only proteoglycan-
specific lymphocytes...
Báo cáo y học: "Gene expression profiling in the synovium identifies a predictive signature of absence of response to adalimumab therapy in rheumatoid arthritis" doc
... significantly overexpressed at baseline in
poor responders are induced by several cytokines in FLSs,
thereby suggesting a role for these cytokines in the resistance
to TNF blockade in RA.
ANOVA: analysis ... immunity,
cytokine- and chemokine-mediated signaling pathways, major
histocompatibility complex II-mediated immunity, and cell
adhesion. Unfortunately, they did not perform any...
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