Báo cáo y học: "Commentary Cyclooxygenase-2: where are we in 2003" potx
Báo cáo y học: "Commentary Cyclooxygenase-2: where are we in 2003" potx
... cardiovascular safety of COX-2 inhibitors. Keywords: cardiovascular risk, cyclooxygenase-2 inhibitors, prothrombotic effects, prostaglandins Commentary Cyclooxygenase-2: where are we in 2003? Cardiovascular ... COX-1 predominates in the stomach, yielding protective prostaglandins, while COX-2 is induced in inflammation giving rise to pain, swelling and discomfort. It has now bee...
Ngày tải lên: 09/08/2014, 01:21
Báo cáo y học: "Functional magnetic resonance imaging findings in fibromyalgia" potx
... alter pain sensitivity at the periphery. These underlying central mechanisms of FM are likely to be reflected in altered supraspinal processing and may originate, in part, at supraspinal sites. The ... sensory fibers are composed of two types: thinly myelinated Aδ fibers and unmyelinated C fibers. Aδ fibers are rapidly conducting and transmit signals that produce perceptions of rela...
Ngày tải lên: 09/08/2014, 08:23
Báo cáo y học: "PARP-1 inhibitors: are they the long-sought genetically specific drugs for BRCA1/2-associated breast cancers"
... cycle checkpoint, and impaired DNA damage repair (reviewed in [8-15]). Hence, BRCA1 is essential for maintaining genome integrity while genetic instability associated with BRCA1 deficiency ... cancer cells to PARP inhibition, there is evidence to suggest that PARP inhibitors may be useful in treating tumors in combination with cytotoxic drugs by increasing the sensitivity of the t...
Ngày tải lên: 31/10/2012, 16:57
Báo cáo Y học: Rodent a-chymases are elastase-like proteases pot
... 226 (according to chymotrypsinogen numbering), comprising the substrate binding site, are generally responsible for controlling the primary substrate specificity of serine proteases [39]. For example, in ... observed in human chymase [37,38]. They hydrolyzed the methylated substrate MeO-succinyl-Ala- Ala-Pro-Val-pNA more effectively than the unmethylated succinyl-Al-Ala-Pro-Val-pNA, pred...
Ngày tải lên: 08/03/2014, 09:20
Báo cáo y học: "QTc and psychopharmacs: are there any differences between monotherapy and polytherapy" ppsx
... therapy Sixty one patients were included in the study. Thirty two women were receiving an antipsychotic or an antidepres- sant (group 1) and twenty nine women were treated with an antipsychotic in ... especially when used in combination. Concomitant use of antipsychotics and antidepressants is not rare in our clinical practice. The study compares the length of QT interval in patient...
Ngày tải lên: 08/08/2014, 21:20
Báo cáo y học: "Commentary on “Genetic linkage and transmission disequilibrium of marker haplotypes at chromosome 1q41 in human systemic lupus erythematosus”, by RR Graham et al" pdf
... following up this linkage data for one of these regions, mapping to 1q41–42 [9]. Linkage analysis identifies genomic regions that are shared, identical-by-descent, by siblings affected by disease more ... would be expected by chance alone. However, linkage typically extends for 10 cM or more and such a region could contain 500 genes. Varia- Commentary Commentary on “Genetic linkage and tran...
Ngày tải lên: 09/08/2014, 03:24
Báo cáo y học: "Proton-pump inhibitors are associated with a reduced risk for bleeding and perforated gastroduodenal ulcers attributable to non-steroidal anti-inflammatory drugs: a nested case-control study" pptx
... co-morbidity or advanced age. In some of these patients the diagnosis was confirmed during autopsy. Patients were included in the study if they used NSAIDs (including selective COX-2 inhibitors) ... However, the efficacy of PPIs and H2RAs in the primary prevention of clinically relevant endpoints, such as bleeding and perforated NSAID ulcers, remains unproven. The discovery of the isoen...
Ngày tải lên: 09/08/2014, 10:20
Báo cáo y học: " Conserved charged amino acid residues in the extracellular region of sodium/iodide symporter are critical for iodide transport activity" potx
... Residues that are identical in all NIS homologs are indicated by asterisks. Residues that are located on the extracellular region are highlighted in grey. Amino acid residues mutated in this study are indicated ... extracellularly and C terminus located intracellularly. Transmembrane segments are represented by cylinders. Positions of 14 amino acid residues mutated in this...
Ngày tải lên: 10/08/2014, 05:21
Báo cáo y học: "NPAS2 and PER2 are linked to risk factors of the metabolic syndrome" pps
... between Clock-gene polymorphism and the metabolic syndrome in man [13,14]. It is of note that we did not find support to these links in our study. We did, however, find several interest- ing ... were successfully genotyped, yielding the suc- cess rate of 100% for all SNPs, and about 5% of samples were re-genotyped to confirm the genotyping results. The following three SNPs were not i...
Ngày tải lên: 10/08/2014, 09:20
Báo cáo y học: "Pre-hospital intubation by anaesthesiologists in patients with severe trauma: an audit of a Norwegian helicopter emergency medical service"
... head injuries. Working Group for Neurosurgical Intensive Care of the European Society of Intensive Care Medicine. Intensive Care Med 1998, 24:1221-1225. 11. Winchell RJ, Hoyt DB: Endotracheal intubation ... Anaesthesiologists are airway management experts, which is one of the reasons why they serve as pre-hospital emergency physicians in many countries. However, limited data are availab...
Ngày tải lên: 25/10/2012, 09:56