Báo cáo y học: "Drugs in development: bisphosphonates and metalloproteinase inhibitors" potx

... is being directed towards the role of cytokines and signalling pathways in the regulation of the MMPs in disease. Blocking of certain cytokines or inhibiting the inflammatory cell signalling path- ways ... tissues by binding to hydroxapatite but that orally administered pyrophosphates are hydrolysed in the gut. Bisphospho- nates are resistant to hydrolysis and so could be adminis- t...

Ngày tải lên: 09/08/2014, 01:21

... respectively) of clinical symptoms. Andrei Calin, of Bath, UK, had started this kind of work in the early 90s with the definition of the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) ... last 10 years both in the clinical and scientific understanding of the spondyloarthritides (SpA), which can be separated in predominantly axial and predominantly peripheral SpA. The cl...

Ngày tải lên: 09/08/2014, 01:22

... generically as a pyrin domain (PYD) in other proteins that have homology with pyrin’s N-terminal sequence [12]. Members of the death domain superfamily are involved in the assembly and activation ... exceptionally rare autosomal dominant disease is caused by mutations in the proline serine threonine phosphatase- interacting protein-1 (PTSTPIP) gene encoding a protein also known as CD2...

Ngày tải lên: 09/08/2014, 01:22

... inflammation after infection. Similar to RASF, macrophages are key players in promoting inflammation and joint destruction in RA by secreting proinflammatory cytokines such as IL-1 and TNFα and by the induction ... discovered ‘novel’ cytokines are also involved in promoting joint inflammation in RA. For example, IL-32, which is intensively expressed in RA synovial tissue, resu...

Ngày tải lên: 09/08/2014, 10:20

... polymyositis or dermatomyositis, which makes IFN-α a potential specific target for therapy in these patients. Cytokines, chemokines, and prostaglandins Proinflammatory cytokines, chemokines, and ... cells in myositis are insufficient and this needs further investigations. Dendritic cell expression and the type I interferon system Recently, DCs were reported in muscle tissue of p...

Ngày tải lên: 09/08/2014, 13:21

... Research & Therapy Vol 10 No 5 So tions for these findings include lifestyle and dietary changes brought about by increasing prosperity and increased life expectancy and age of the population. Uric ... inflammatory infiltrate rich in neutrophils when injected into the peritoneum or in the air pouch in animal models. The capacity of MSU crystals to stimulate monocyte/macrophage...

Ngày tải lên: 09/08/2014, 13:22

... through the activity of inhibitory neurotransmitters, which include serotonin, norepinephrine, enkephalins, γ-amino butyric acid and adenosine. A decrease in this pain inhibitory loop is an important ... provides clinically meaningful benefit to patients with FM. In another study Mease and colleagues evaluated the safely and efficacy of milnacipran, a dual norepinephrine and serot...

Ngày tải lên: 09/08/2014, 14:21

... Receptor Binding Studies Using [ 3 H] 5-Hydroxytryptamine 5-HT receptor assay was done using [ 3 H] 5-hydroxy- tryptamine binding in crude synaptic membrane pre- parations of hippocampus by the modified ... potentiating of insulin effect of plasma by increasing the pancreatic secretion of insulin from existing b-cell or its release from bound insulin intercede by increase in t he insulin...

Ngày tải lên: 10/08/2014, 05:21

... artery anteriorly may cause compression syn- dromes producing ischemia. The subclavian and axillary system of arteries is derived from the seventh cervical intersegmental artery. Hence, the artery ... [12]. In a study done by Pandey and Shukla on 172 cadavers, in 8 cadavers, the median nerve was formed medial to the artery and traveled as such [13]. Anomalous branches of lateral cor...

Ngày tải lên: 10/08/2014, 10:20

... timing or coupling of joint movements has been shown to be a useful tool for understanding injury aetiology based on the notion that asynchrony in joint coupling and changes in joint coupling ... foot kinematics and injury potential, the purpose of this study was to reanalyze the data and investigate shank, rearfoot and forefoot joint coupling and coupling variability during wal...

Ngày tải lên: 10/08/2014, 21:24