... threoninekinase activity, at least in vitro [13]. Consistent withthis, we found YpkA to be present in the same proteincomplex as OTUB1 in living cells and during bacterialinvasion, as assessed by co-immunoprecipitation.Moreover, ... during Yersiniainvasion [19]. In addition to its serine ⁄ threonine kinaseactivity [13,15,37] and binding to actin [12], YpkA hasbeen shown to interact with small GTPases and inhibitnucleotide ... of OTUB1 (CS91S, Fig. 2A).Increased susceptibility to Yersinia in the presence ofoverexpressed OTUB1 was observed as early as 15 min after invasion, and decreased over time, proba-bly because...