Báo cáo y học: "Psychiatric disorder as clinical presentation of primary Sjögren’s syndrome: two case reports " pdf
Báo cáo y học: "Psychiatric disorder as clinical presentation of primary Sjögren’s syndrome: two case reports." pdf
... as: Pelizza et al.: Psychiatric disorder as clinical presentation of primary Sjögren’s syndrome: two case reports. Annals of General Psychiatry 2010 9:12.Pelizza et al. Annals of General Psychiatry ... CASE REPO R T Open AccessPsychiatric disorder as clinical presentation of primary Sjögren’s syndrome: two case reports Lorenzo Pelizza*, Federica Bonacini, Alberto FerrariAbstractPsychiatric ... For primary SS. In patients without any potentiallyassociated disease, primary SS may be defined as follows:(a) The presence of any four of the six items is indica-tive of primary SS, as long...
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Báo cáo y học: " Epratuzumab (humanised anti-CD22 antibody) in primary Sjögren''''s syndrome: an open-label phase I/II study" docx
... measures, including subjective reports of dryness, fatigue, and salivary flow, mainly in patientswith early-onset disease and in only a few with pSS-associ-ated MALT (mucosa-associated lymphoid ... cells, which wasdownregulated by epratuzumab for at least 12 weeks after thetherapy.In addition to assessing any evidence of efficacy, the objective of this open-label phase I/II study was to evaluate ... theabsence of validated disease activity criteria for pSS, wedeveloped a disease activity score based on the most frequentsigns and symptoms of the disease. These included fourdomains: dryness of...
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Báo cáo y học: "Natural History and Clinical Consequences of Hepatitis B Virus Infection"
... development of cirrhosis as well as mortality. Genotype C is associated with a higher risk of cirrhosis than genotype B based on studies in Asian patients [27]. The presence of any other independent ... history of an immunologically mediated liver disease. Gastroenterology 2001;120:1009-1022. 9. Fattovich G. Natural history of hepatitis B. Journal of Hepatology 2003, 39: S50-S58. Types Risk ... clearance clinically present as HBeAg positive chronic hapatitis B. The stage of inactive phase clinically presents as HBsAg carrier. * During the stage of reactivation, majority of patients...
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Báo cáo Y học: Protein methylation as a marker of aspartate damage in glucose-6-phosphate dehydrogenase-deficient erythrocytes docx
... effects of such treatment onisoaspartate formation, by measuring the levels of mem-brane protein methyl esters by the in situ methylation assay.PK activity was also measured in parallel, to assess ... G6PD-deficient ery-throcytes, damaged residues are significantly increased inmembrane proteins, in parallel with the decay of pyruvatekinase activity, used as a cell age marker. Erythrocytes frompatients ... andhaemolysis has not been unequivocally elucidated. AmongG6PD-deficient erythrocytes, aged cells are the mostsensitive to haemolysis, because of age-dependent decay of the activity of several enzymes,...
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Báo cáo y học: "Developments in the clinical understanding of osteoarthritis" docx
... NSAID/cyclooxygenase-26. Avoid use in persons with prior gastrointestinal (GI) bleeding ulcers, upper GI surgeryTable 2Gastrointestinal risk of non-steroidal anti-inflammatorydrugs/cyclooxygenase-2 ... diseases of aging for whichthere is little, if any, effective treatment. It accounts for moremobility disability in the elderly than any other disease.Symptomatic knee OA affects roughly 12% of ... cartilage has eroded. The synovium oftendevelops lining cell hyperplasia and in some cases becomesinfiltrated with subsynovial inflammatory cells [4]. Activatedsynovium secretes excess synovial...
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Báo cáo y học: "Developments in the clinical understanding of rheumatoid arthritis" ppt
... such as cardiovascular diseaseand lymphoma, and economic consequences,including loss of working capacity, areassociated primarily with the severity of RA as manifested by chronic high disease ... active disease Clinical fact 1Composite indices are the best depicters of disease activity. The degree of disease activityat the start of a disease-modifying therapy is amajor determinant of the ... physical function even in theabsence of joint damage (such as in very early activedisease), while patients with severely destroyed joints maysuffer from disability even in the absence of any...
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Báo cáo y học: "The role and clinical implications of G6PI in experimental models of rheumatoid arthritis" pptx
... unanswered.Why the joint?It is currently unclear why systemic autoreactivity againstthe ubiquitously expressed glycolytic enzyme G6PIspecifically induces arthritis, with no other symptoms of organ-specific ... cell recognition of a glycolytic enzyme.Science 1999, 286:1732-1735.67. Gracy RW, Tilley BE: Phosphoglucose isomerase of humanerythrocytes and cardiac tissue. Methods Enzymol 1975, 41:392-400.68. ... implicatemacrophages as the major effector cells in the clinicallyovert stages of RA [7,23].Most recently, however, two different lines of evidence re-assert the importance of T cells. First, a large clinical...
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Báo cáo y học: "Plasma gelsolin as a biomarker of inflammation" doc
... original hypo-thesis about the function of circulating gelsolin was that itscavenged actin released from cells at the site of injury. Althoughextracellular actin may be the primary cause of gelsolin ... Gelsolin wasfirst identified as a cytoplasmic actin-regulatory proteinessential for cell locomotion and phagocytosis. When acirculating isoform was subsequently discovered, its physio-logical ... extracellular actin filaments[2]. Hypogelsolinemia ensues after a wide spectrum of seemingly unrelated types of insults and precedes a secondwave of injury that typically involves organs distant from...
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Báo cáo y học: "The biological and clinical importance of the ‘new generation’ cytokines in rheumatic diseases" pot
... indicate that some of these cytokines contribute to the pathophysiology of arthritis andother inflammatory diseases. Targeting of some of these cytokineshas already been tested in clinical trials ... utility of thiscytokine in pathology. A further intriguing approach is tomodulate the synthesis and release of IL-18. Whereas theinhibition of caspase-1 using orally bioavailable inhibitors wasnot ... reduces chondrocyte proliferation, upregulates inducibleNO synthase, stromelysin, and cyclooxygenase 2 (COX2)expression, and increases glycosaminoglycan release. IL-18further promotes synovial chemokine...
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