Báo cáo y học: "Convulsive liability of bupropion hydrochloride metabolites in Swiss albino mice" ppt
Báo cáo y học: "Convulsive liability of bupropion hydrochloride metabolites in Swiss albino mice" ppt
... within 15 min of dosing with threo-
hydrobupropion HCl 75 mg/kg, and four mice and one
mouse within 30 min and 45 min, respectively, of dosing
with hydroxybupropion HCl 75 mg/kg. In addition, clin-
ical ... mouse following the intraperitoneal administration of bupropion HCl and bupropion metabolites
Dose* (mg/kg) Bupropion HCl Erythrohydrobupropion HCl Threohydrobupropion HCl...
Báo cáo y học: "α Paradoxical effects of tumour necrosis factor-α in adjuvant-induced arthritis" pptx
... changing, roles in the overall patho-
genesis of this form of arthritis.
In the light of the findings presented by Kim and colleagues
[1], it is interesting that a small number of studies have ... disease
severity [5]. In another study, EAE failed to resolve in TNFα
-/-
or TNFR
-/-
mice, suggesting that TNFα plays an important role
in resolution of inflammation [6]. In m...
Báo cáo y học: "Increased levels of circulating Annexin A5 in Familial Mediterranean fever." ppt
... based upon flow-cytometry data
indicating increased rate of apoptosis of subpopulations
of leukocytes involved in autoinflammation and recur-
rent episodes of fever in FMF [7].
In addition, our ... since it preferentially binds PS with high affinity and inhi-
bits apoptotic cell uptake by phagocytes [12,13].
ANX-V is produced by a variety of cells and is an in
vivo marker o...
Báo cáo y học: " Low concentration of ethanol induce apoptosis in HepG2 cells: role of various signal transduction pathways"
... its initial effect on protein kinases
phosphorylation.
The most strikingly and novel finding obtained
hereby was the strong inhibition of the GPCR signaling
pathway induced mainly by increased ...
signaling pathways. The pro-apoptotic effect induced
by ethanol was demonstrated by a strong inhibition of
GPCR signaling pathway in association with a slight
inhibition of JNK and N...
Báo cáo Y học: The presence of a helix breaker in the hydrophobic core of signal sequences of secretory proteins prevents recognition by the signal-recognition particle in Escherichia coli doc
... variable in the interaction
with SRP [14,41,42]. However, the hydrophobicity of
cysteine is even slightly lower than that of glycine [37].
Therefore, the cross-linking of (G-10C)prePhoE to P48
indicates ... preprotein is
translocated by an insertion–deinsertion cycle of SecA into
the SecYEG translocon [8]. Energy for the translocation
process is provided by ATP hydrolysis by SecA [8...
Báo cáo Y học: Functional epitope of common c chain for interleukin-4 binding ppt
... some of the binding residues of c
c
defined in our study also participate in IL-2 and IL-7
binding, as, in the aforementioned s tudy, only one re sidue
(Y1 03) was shown to be directly involved in ... nd local
determinants for the kinetics o f interl eukin- 4/interleuk in- 4
receptor alpha chain i nteraction . A biosensor s tudy employing
recombinant interleukin-4-binding protein...
Báo cáo Y học: Coordinated action of protein tyrosine phosphatases in insulin signal transduction potx
... homogeneous
preparations of PTP-1B protein into Xenopus oo cytes
decreases t yrosine phosphorylation of proteins correspond-
ing to the molecular m ass of the IR. Correspondingly,
insulin-induced S6 kinase activity ... regulatory s ubunit of phosphatidylinositol 3-kinase
(PI3-kinase). Binding to p85 recruits the p110 catalytic
subunit of PI3-kinase, resulting in the activation of...
Báo cáo Y học: Identification of mammalian-type transglutaminase in Physarum polycephalum Evidence from the cDNA sequence and involvement of GTP in the regulation of transamidating activity potx
... calcium-binding protein in
P. polycephalum, was shown to be a substrate of PpTGase
Fig. 7. Time-courses of GTP hydrolysis by TGase 2, TGase 3, and
PpTGase. GTP-hydrolysing activities of guinea pig ... might be similar to that by
which they inhibit the enzymatic activity of TGase 4.
Hydrolysing activity of GTP was also found in the
purified PpTGase protein as in the case of TG...
Báo cáo Y học: Detailed characterization of polydnavirus immunoevasive proteins in an endoparasitoid wasp doc
... respectively, instead of the calyx
cells. Further, the expression of IEP proteins is not
synchronized with that of CkPDV capsid proteins; IEP
proteins were observed approximately one day after the
initiation ... (IEP-1) deter-
mined in the prior study [21] is underlined. The
amino acid sequence (10 amino acids) of IEP-2
determined in the present study is also
underlined. Potential...
Báo cáo y học: " Immunohistochemical Characteristics of Bone Forming Cells in Pleomorphic Adenoma" ppt
... (4)]. In some
instances, there were remodeling lines which were
deeply stained with hematoxylin.
Immunohistochemically, S-100 protein-positive
products were detected in the cytoplasm of modified ... reversal line
indicated by deeply-stained hematoxylin structure
with osteoclasts and osteoblasts. This finding suggests
that bone formation occurred over a long period of
time.
In...