Báo cáo khoa học: "Treatment of bipolar disorder: a complex treatment for a multi-faceted disorder" pdf

báo cáo khoa học: "Identification of improved IL28B SNPs and haplotypes for prediction of drug response in treatment of hepatitis C using massively parallel sequencing in a cross-sectional European cohor" pot

... Matsuura K, Sakamoto N,Nakagawa M, Korenaga M, Hino K, Hige S, Ito Y, Mita E, Tanaka E,Mochida S, Murawaki Y, Honda M, Sakai A, Hiasa Y, Nishiguchi S, Koike A, Sakaida I, Imamura M, Ito K, Yano ... IL28B.Variant calling and association testingCRISP detected 1221 SNVs and 118 indels (1339 var-iants in total).Validation with original GWAS SNP data and HapMapdataCRISP called all 15 of the ... PCR, for smaller association signals. PCR can lead to amplificationartefacts that can be alleviated, at least in part, withadvanced lab protocols [22] which would result in moreuniform coverage...

Tài liệu Báo cáo khoa học: Perturbation of membranes by the amyloid b-peptide – a molecular dynamics study pptx

... Ma J & JiangH (2005) Conformational transition of the amyloidb-peptide. Proc Natl Acad Sci USA 102, 5403–5407.25 Lemkul JA & Bevan DR (2008) A comparative molecu-lar dynamics analysis ... Area per lipid headgroup as a function of time for control DPPC simulations.Fig. 5. Area per lipid headgroup as a function of distance from the protein; simulations A1 and A2 are shown at each ... phenomenon. A greater knowledge of themost basic interactions between Ab and a model mem-brane can lead to a more complete understanding of the membrane-aided assembly of Ab and the resultingdamage...

Tài liệu Báo cáo khoa học: Phosphorylation of hormone-sensitive lipase by protein kinase A in vitro promotes an increase in its hydrophobic surface area ppt

... the antisense primer5¢-AAG AATTCT AGA TTA ATG GTG ATG ATG GTGATG ATG GTG TGG GGT CAG CGG TGC AGC AGGGGG GGT-3¢ (XbaI sites underlined; His-tag in italic) andpVL1393–HSL [18] as template was ... by bis-ANS wasdecreased upon phosphorylation. A possible explana-tion for this apparent discrepancy could be that PKAphosphorylation induces a conformational change thatincreases the accessible ... phosphorylation was notnecessary, probably because of a lower degree of interaction of ATP with SYPRO Orange than withbis-ANS. The molar concentration of SYPRO Orangeis impossible to calculate, as...

Tài liệu Báo cáo khoa học: "Integration of Speech to Computer-Assisted Translation Using Finite-State Automata" pdf

... (Papineni et al., 1997; Papineniet al., 1998) for a natural language understandingtask, by (Beyerlein, 1998) for an ASR task, andby (Och and Ney, 2002) for an MT task. Thisapproach is a generalization ... target part of these phraseswe build a transducer similar to the lexicon-basedtransducer. But instead of a target word on eacharc, we have the target part of a phrase. The weight of each arc ... what a human trans-lator types. The integration of humanspeech into a computer-assisted system isalso a challenging area and is the aim of this paper. So far, only a few methods for integrating...

Báo cáo khoa học: Transport of L-arginine and nitric oxide formation in human platelets pdf

... intolerance(LPI). Hum. Mol. Gen. 9, 431–438.42. Kamada, Y., Nagaretani, H., Tamura, S., Ohama, T., Maruyama,T.,Hiraoka,H.,Yamashita,S.,Yamada ,A. ,Kiso,S.,Inui,Y.,Ito, N., Kayanoki, Y., Kawata, ... theaddition of cold 2Mperchloric acid. Extracts were neutral-ized and analyzed for the cGMP content by RIA kit.Data analysisData are the mean ± SD of at least four independentdeterminations, each ... experimental[9–11] and clinical studies [12–15] demonstrated that thedecrease of vascular and platelet NO activity can be reversedby oral and intravenous administration of L-arginine. ThustheL-arginine...

Báo cáo khoa học: Assessment of porcine and human 16-ene-synthase, a third activity of P450c17, in the formation of an androstenol precursor doc

... performed transfection assays with increasing amounts of DNA fragments encoding cyt b5and monitored theformation of androstadienol and DHEA. As shown inFig. 5 the stimulation of DHEA and androstadienolproduction ... used as standards, showedelution peaks at 4.70, 2.30 and 2.50 min, respectively(Fig. 2). In both porcine and human assays using preg as a substrate, an additional peak of elution appeared at15 ... indicatedamounts of pCMV-cyt b5. The transfected cells were analyzed for theirability to catalyze the transformation of 5 nM of [3H]preg to andro-stadienol. An increase in 16-ene-synthase...

Báo cáo khoa học: "EVALUATION OF NATURAL LANGUAGE INTERFACES TO DATABASE SYSTEMS: A PANEL DISCUSSION " ppt

... EVALUATION OF NATURAL LANGUAGE INTERFACES TO DATABASE SYSTEMS: A PANEL DISCUSSION Norman K. Sondheimer, Chair Sperry Univac Blue Bell, PA For a natural language access to database system ... intermedlary[l]? What are the independent variables that must be allowed for? What tools are available to determine user bias and experience beforehand, and user satisfaction afterward? IIl. ... basis of these evaluations, what should the future look like for natural language access to database? Under this point, what niches look most promising for natural language interfaces? What...

Báo cáo khoa học: Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting pdf

... Berdiaki A, Kletsas D, Zaﬁropoulos A, Theocharis AD, Tzanakakis GN & Karamanos NK(2008) Estradiol–estrogen receptor: a key interplay of MMPs as potential targets in malignancy C. Gialeli et al.26 ... both apoptotic andanti-apoptotic actions. MMPs and ADAMs, especiallyMMP-7 and ADAM10, confer anti-apoptotic signalsto cancer cells by cleaving Fas ligand, a transmem-brane stimulator of the ... Anti-apoptoticADAM10 Shedding of tumor associated majorhistocompatibility proteins complex class-ISeveral MMPs and ADAMs Indirect activation of Akt through activation of EGFR and IGFRTumor angiogenesis...

Báo cáo khoa học: Modulation of aryl hydrocarbon receptor transactivation by carbaryl, a nonconventional ligand pptx

... Casado S, Alonso M, Herrado´n B, Tarazona J & NavasJ (2006) Activation of the aryl hydrocarbon receptor bycarbaryl: computacional evidence of the ability of carba-ryl to assume a planar ... system, carbarylacted as an antagonist because simultaneous addition of 1 lm of a typical AhR ligand, b-naphthoﬂavone(BNF), and increasing concentrations of carbaryl resul-ted in a typical inhibition ... for ligand-dependent transcriptional activation by AhR isthe Spt-Ada-Gcn5-acetyltransferase (SAGA) complex [31], a HAT complex required for function in yeast of many, but not all, transcriptional activators,...

Báo cáo khoa học: Binding of non-natural 3¢-nucleotides to ribonuclease A ppt

... with water. (The pH of the water wash was % 13) Glacial acetic acid (0.5 mL)was added, the layers were separated, and the organic layerwas washed again with water. The layers were separated,and ... 3¢-nucleotideswith a non-natural furanose ring can have a greaterafﬁnity for a ribonuclease than do 3¢-nucleotides with a ribose or deoxyribose ring. The values of Ki for inhibi-tion of catalysis by RNase A ... arabinonucleo-sides. For example, Dharma and coworkers havedemonstrated that arabinonucleotides are effectiveantisense agents [40]. In addition, the antineoplasticdrug ﬂudarabine is an arabinonucleoside, and...

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