... establishing the real contribution of GCs to OP in RA is challenging because bone mineralloss is of multifactorial origin in these patients, and itmay be influenced by inflammatory cytokines, inactivity,GCs, ... use in a population of early arthritis patients. In addition, we studied theimpact of different factors on the evolution of mineralbone content in these patients, including GC use.Materials and ... therapy to elderly patients, men, and patients with severe forms of the disease. Thispattern of use, starting on average with 15 mg/d of predni-sone and tapering toward withdrawal about 1 year...