Báo cáo y học: "Allergen-specific T cell quantity in blood is higher in allergic compared to nonallergic individuals" pptx
Báo cáo y học: "Allergen-specific T cell quantity in blood is higher in allergic compared to nonallergic individuals" pptx
... Asymptomatic subjects (without symptom s of asthma, rhinitis or eczema) were recruited by advertising. They were included into the study as nonallergic subjects” only if they were SPT-negative ... IgE than allergen-specific B cells. The third important finding of the study is the simi- larity in allergen -specific Th cell quantity when analyzed at different time-points. This suggest...
Ngày tải lên: 08/08/2014, 21:20
Báo cáo y học: " ytotoxic T cell recognition of an HIV-1 reverse transcriptase variant peptide incorporating the K103N drug resistance mutation" pot
... wild type was not. The RT K103N mutation is selected by the NNRTI class of HIV drugs. We hypothesize that, in certain individuals, CTL responses against 103N-containing epitopes may protect against ... RT NNRTI drug resistance. Clinically, this mutation is potent as a sin- gle mutation and causes cross resistance to drugs in this class [12]. We hypothesized that certain individuals...
Ngày tải lên: 10/08/2014, 05:20
Báo cáo y học: "The retinoic acid binding protein CRABP2 is increased in murine models of degenerative joint disease" pot
... activated early in the osteoarthritic process and is sustained during the course of the disease. Introduction Osteoarthritis (OA) is a degenerative joint disease (DJD) that impacts multiple joint tissues ... regulated by retinoic acid and its increase in expression is consistent with activation of this path- way. CRABP2 has been shown to function both to suppress retinoic acid r...
Ngày tải lên: 09/08/2014, 01:22
Báo cáo y học: "Peroxisome proliferator-activated receptor γ1 expression is diminished in human osteoarthritic cartilage and is downregulated by interleukin-1β in articular chondrocytes" doc
... mPGES-1 [14-16]. The inhibitory effect of PPARγ is partly due to antag- onizing the transcriptional activity of the transcription factors NF-κB, activator protein 1 (AP-1), signal transducers and acti- vators ... Rheumatology Diagnostic Subcommittee for OA [19]. At the time of surgery, the patients had symptomatic disease requiring medical treatment in the form of non-steroidal anti- in...
Ngày tải lên: 09/08/2014, 10:20
Báo cáo y học: "Differential clinical efficacy of anti-CD4 monoclonal antibodies in rat adjuvant arthritis is paralleled by differential influence on κ α NF-κB binding activity and TNF-α secretion of T cell" pot
... (with distinct epitope specifities) in the treatment of rat adjuvant arthritis (AA) and on T- cell function and signal transduction. Rat AA was preventively treated by intraperitoneal injection ... TNF-R75 in the rheumatoid synovial membrane: TNF receptors are localized preferentially in the lining layer; TNF-alpha is distributed mainly in the vicinity of TNF receptors in the d...
Ngày tải lên: 09/08/2014, 03:24
Báo cáo Y học: Proteasome-driven turnover of tryptophan hydroxylase is triggered by phosphorylation in RBL2H3 cells, a serotonin producing mast cell line pptx
... virtually stopped by proteasome inhibitors MG132 and lactacystin but was not affected by a cystein protease inhibitor, E-64-d; a representative finding showing that the steady state level of TPH ... kinase-specific phosphorylation. Phosphorylation of TPH as the tag for proteolysis targeting The role of TPH phosphorylation is that it down regulates the TPH level in the cell by serving a ta...
Ngày tải lên: 08/03/2014, 16:20
Báo cáo Y học: Bax-induced cell death in yeast depends on mitochondrial lipid oxidation doc
... increase in satur- ated fatty acids. The total amount of fatty acids in whole cells was not significantly affected (data not shown) but the amount of fatty acids in isolated mitochondria was markedly ... proteins sharing sequence homology restricted to only the BH3 domain (e.g. Bid, Bad). These proteins do not have pro-apoptotic activity by themselves but do potentiate the pro-apoptoti...
Ngày tải lên: 23/03/2014, 21:20
Báo cáo hóa học: "Regulatory T cell frequency in patients with melanoma with different disease stage and course, and modulating effects of high-dose interferon-a 2b treatment" pptx
... better understanding of the mechan- ism of act ion of IFN-a 2b may facilitate the development of treatment strategies to increase efficacy and reduce toxicity, ultimately leading to a better stan- dard ... 2b treatment During the first week of treatment, all patients were hospitalized to evaluate tolerability. Providing no severe toxicity was observed, patients were referred to daily...
Ngày tải lên: 18/06/2014, 16:20
Báo cáo y học: "Hematopoietic stem cell transplantation for systemic lupus erythematosus" ppsx
... constantly fluctuating between tolerance and immunity. This dynamic state is best demon- strated by the intermittent clinical course of some autoim- mune diseases such as relapsing-remitting multiple sclerosis, ... cells in a healthy person normally possess a T- cell receptor repertoire selected to a self-epitope. Immune cells may be viewed as a dynamic equilibrium that maintains ste...
Ngày tải lên: 09/08/2014, 01:23
Báo cáo y học: "Collagen type II (CII)-specific antibodies induce arthritis in the absence of T or B cells but the arthritis progression is enhanced by CII-reactive T cells" ppsx
... response. Interestingly, the T cell line cross-reacted to the glyco- sylated mouse peptide, and the lower reactivity to the mouse glycopeptide than to the rat glycopeptide is most probably dependent on both the ... affinity of the mouse peptide for A q and also a different reactivity of the clonally distinct glycopeptide-reactive T cells [7]. To investigate the role of T ce...
Ngày tải lên: 09/08/2014, 01:24