... assembly, and also bind phosphati- dylinositol-4,5-bisphosphate and poly-proline, thus being important in signalling pathways. Profilins are highly expressed in pollen, but usually act as minor ... is lower (25%) and could be improved using another pro- tease, since the sequence contains very few arginine and lysine residues implicating that cleavage with trypsin max- imally can y...
Ngày tải lên: 13/08/2014, 13:22
... cell death induced by pro-inflammatory cytokines. Finally, Yudoh and colleagues showed that HIF-1α is necessary for anaerobic energy generation and proteoglycan synthesis by articular chondrocytes, ... expression of VEGF-A via HIF-1. In conclusion, the α-subunit of HIF-1 is stabilized and HIF-1 activity is significantly increased in chondrocytes by hypoxic, inflammatory and me...
Ngày tải lên: 09/08/2014, 07:20
Báo cáo y học: " The role of γδ T cells in airway epithelial injury and bronchial responsiveness after chlorine gas exposure in mice" pps
... findings are consistent with a role of γδ T cells in determining the magnitude of the inflammatory response to acute epithelial injury and in maintaining and repairing the epithelial barrier [16]. ... of respiratory system resistance (A; R RS ) and respira- tory system dynamic elastance (B; E RS ) following intravenous injection of methacholine in wildtype and knockout m...
Ngày tải lên: 12/08/2014, 15:20
Báo cáo y học: "The identification of eosinophilic gastroenteritis in prednisone-dependent eosinophilic bronchitis and asthma" potx
... a patient who likely has a lymphocytic variant of hypereosinophilic syndrome that resulted in eosinophilic infiltration of the gastroin- testinal tract, sinuses, and airway that contributed to variable ... identify eosinophilic inflammation. Introduction Eosinophilic gastrointestinal disease (EGID) is character- ized by identification of abnormal eosinophilic infiltra- tio...
Ngày tải lên: 08/08/2014, 21:20
Báo cáo y học: "The identification of unique serum proteins of HIV-1 latently infected long-term non-progressor patients" doc
... of the family of serine/threonine kinases that are integrally involved in key cellular signaling pathways and can phos- phorylate a wide variety of substrates. Not surprisingly, HIV-1 infection ... tumor-suppressor pathway which acts to arrest the cell-cycle at G1/S by inhibiting the binding of cdk4/6 to Cyclin D1 and subse- quently inhibiting the phosphorylation of Rb. In F...
Ngày tải lên: 10/08/2014, 05:21
Báo cáo y học: "The Syndrome of Frontonasal Dysplasia, Callosal Agenesis, Basal Encephalocele, and Eye Anomalies – Phenotypic and Aetiologica"
... observed in the present condition are embryological related, occurring in the same critical period of time, most likely during the early induction of the forebrain, resulting in anomalies involving ... hallmark of several syndromes involving the frontonasal process that includes: isolated frontonasal dysplasia (MIM 136760 and 305645), acrofrontofacionasal dysostosis 1 (MIM 2...
Ngày tải lên: 03/11/2012, 10:05
Báo cáo Y học: The expression of glutathione reductase in the male reproductive system of rats supports the enzymatic basis of glutathione function in spermatogenesis doc
... ma intained by two s ystems. One is de novo synthesis from b uilding blocks, glutamate, cysteine, and glycine, via two ATP-con suming s teps involving c-g lut- amylcysteine synthetase ( cGCS) and ... in both arginine and cysteine. The cysteine sulfhydryls in protamine must form disulfide bond to package DNA into small sperm head during the maturation process. Thus, while cysteine, a...
Ngày tải lên: 17/03/2014, 17:20
Báo cáo Y học: The role of arginine residues in substrate binding and catalysis by deacetoxycephalosporin C synthase potx
... carboxyl group of the a-aminoadipoyl- side-chain of penicillin N (1), with arginines 74 and 75 apparently playing a less important role in side-chain binding. Taken together, the results of this and ... residues in binding the carboxylate linked to the nucleus of penicillin N (Arg160 and Arg162) and the carboxylate of the a-amino- adipoyl side-chain (Arg266). The results...
Ngày tải lên: 18/03/2014, 01:20
Báo cáo y học: "The prevalence of mental disorders in adults in different level general medical facilities in Kenya: a cross-sectional study" pot
... study and was involved in drafting the manuscript and revising it critically for intellectual content. LIK participated in acquisition, analysis and interpretation of data and was involved in ... analysis and interpreta- tion of data and was involved in drafting the manuscript. FAO-O participated in acquisition of data and was involved in drafting the manuscrip...
Ngày tải lên: 08/08/2014, 23:21
Báo cáo y học: "The role of cyclooxygenase-2 in bone repair" doc
... activity of a glucocorticoid-regulated inflammatory cyclooxygenase. Proc Natl Acad Sci USA 1992, 89:4888-4892. 7. Raskin JB: Gastrointestinal effects of nonsteroidal anti-inflam- matory therapy. ... tolerated and equally efficacious in man- aging inflammation. However, whereas the selectivity of this group of compounds might allow inflammation to be inhibited with minimal effects...
Ngày tải lên: 09/08/2014, 01:21