Báo cáo y học: "Eotaxin and FGF enhance signaling through an Extracellular signal-related kinase (ERK)-dependent pathway in the pathogenesis of Eosinophilic Esophagitis" doc

... this increase is also reflected systemically. In addition, the extent of increase in FGF and ERK pathways was closely associated with the sever- ity of the disease and endoscopic findings in the ... obtaining biopsy and blood samples. NR and LH were involved in enrolling and consenting patients. JH drafted the manuscript. All authors read and approved the...

Ngày tải lên: 08/08/2014, 21:20

... beneficial and life saving. Con: Recombinant FVIIa is not a cure for all bleeding Sandro Scarpelini and Sandro Rizoli We understand the clinical scenario and debate question as whether one should administer ... evidence. Crit Care Clin 2005, 21:611-632. 12. Planinsic RM, van der Meer J, Testa G: Safety and efficacy of a single bolus administration of recombinant factor VIIa in...

Ngày tải lên: 12/08/2014, 23:24

... reaction in the mouse skin [58], and attenu- ated leukocyte infiltration and airway hyperresponsiveness in a model of allergic airways inflammation in the mouse by antagonizing both CCR3 and CCR1 ... small protein, the chemokine eotaxin, is synthesized by a number of different cell types, and is stimulated by interleukin-4 and interleukin-13, which are produced by T-...

Ngày tải lên: 12/08/2014, 18:20

... change, one mediated by Rho kinase and the other by the Ca 2+ -dependent activation of MLC kinase. These two pathways could be activated independ- ently of each other, depending on the type and ... rearrangements, by inhibiting actin assembly and focal adhesion in many cell types [8,9] through the decreased phosphorylation of various proteins [10,11] including MLC [...

Ngày tải lên: 21/02/2014, 01:21

... collected the data and has involved in revising the manuscript. JB and TV have given assistance to analysing the data and have revised the manuscript. HL has contributed in collecting the data and ... City, Helsinki, Finland. 3 Department of Cardiology, Helsinki University Central Hospital of Meilahti, 00290 Helsinki, Finland. Authors’ contributions SS has analysed...

Ngày tải lên: 13/08/2014, 23:20

... rating 2), SPINK5 (CGC points 14.2, CGC ranking 4, manual rating 3), IK (CGC points 14.1, CGC rank- ing 5, manual rating 3) and CD14 (CGC points 12.8, CGC ranking 6, manual rating 2). Two of these ... Council, the SWEGENE Foundation, the Sven and Lilly Lawski Founda- tion, the Royal Society of Arts and Sciences in Goteborg, the Wilhelm and Martina Lundgren Research Foun...

Ngày tải lên: 09/08/2014, 06:22

... Zhe Yu, Yuan Fang and Fansheng Kong Abstract Objective: To evaluate the efficacy of enhanced, intensive, immuno-suppressive therapy with umbilical cord blood support for severe aplastic anemi ... total of 25 patients with SAA received enhanced, intensive, immuno-suppressive therapy and a cord blood transfusion. Therapy protocol: Anti-thymocyte globulin (ATG) 2.5 mg/(kg•d) × 5d; Cycl...

Ngày tải lên: 10/08/2014, 21:23

... densi- tometry was used to quantify the protein band and com- pared to either the protein loading control such as β-actin or the same protein at the baseline. Competing interests The authors declare ... activation of the cyclin-dependent kinase 1 (Cdk1), which determines onset of mitosis in all eukary- otes [12-14]. Cdk1 is typically phosphorylated on Tyr15 by Wee1 kina...

Ngày tải lên: 13/08/2014, 01:20

... neurons and glial cells [5]. FGF- 2 protein and messenger RNA (mRNA) have been found in the cytoplasm of neurons and in thenucleiofastrocytesof many brain regions [5-8]. FGF- 2 plays a role in the ... demonstrated increased synth- eses of the cytoskeletal proteins actin and tubulin after axotomy of the rat facial nerve simultaneously to the enhanced NF contents...

Ngày tải lên: 10/08/2014, 10:20

... thank all the study participants. Author details 1 Department of Allergology and Internal Medicine, Medical University of Bialystok, Poland. 2 The Teaching Hospital of the Medical University of Bialystok, ... patients and healthy volunteers were non-smokers and during the last year had not been passive smokers. The scheme of the procedures during the study After...

Ngày tải lên: 12/08/2014, 11:22