Báo cáo y học: "Eotaxin and FGF enhance signaling through an Extracellular signal-related kinase (ERK)-dependent pathway in the pathogenesis of Eosinophilic Esophagitis" doc

... this increase is also reflectedsystemically. In addition, the extent of increase in FGF and ERK pathways was closely associated with the sever-ity of the disease and endoscopic findings in the ... obtaining biopsy and blood samples. NR and LH were involved in enrolling and consenting patients. JH drafted the manuscript. All authors read and approved the final manuscript.Competing interests The ... would like to thank the Stanford FACS facility, the QT-PCR facility, and the Institute for Immunity,Transplantation, and Infectious Diseases and the Human Immune MonitoringCenter for their services.Author...

Báo cáo y học: " Pro/Con Debate: Does recombinant factor VIIa have a role to play in the treatment of patients with acute nontraumatic hemorrhage" ppt

... beneficial and life saving.Con: Recombinant FVIIa is not a cure for all bleedingSandro Scarpelini and Sandro RizoliWe understand the clinical scenario and debate question aswhether one should administer ... evidence. Crit Care Clin2005, 21:611-632.12. Planinsic RM, van der Meer J, Testa G: Safety and efficacy of asingle bolus administration of recombinant factor VIIa in livertransplantation due to ... efficacious in many but not all circumstances. Apartfrom ongoing bleeding, even off-label use demandsreasonable expectation of benefit. Ongoing bleeding and reasonable expectation of benefit are mandatory...

Báo cáo y học: " Eotaxin and the attraction of eosinophils to the asthmatic lung" ppt

... reaction in the mouse skin [58], and attenu-ated leukocyte infiltration and airway hyperresponsiveness in a model of allergic airways inflammation in the mouse byantagonizing both CCR3 and CCR1 ... small protein, the chemokine eotaxin, is synthesized by a number of different cell types, and is stimulated by interleukin-4 and interleukin-13, which are produced byT-helper (Th)2 lymphocytes. Low ... similarity of less than 40% and differalmost entirely in the amino-terminal region. The humaneotaxin gene is located on chromosome 17q11.2 in the C-C chemokine cluster, whereas eotaxin-2 and eotaxin-3have...

Tài liệu Báo cáo Y học: Convulxin induces platelet shape change through myosin light chain kinase and Rho kinase ppt

... change, one mediated by Rho kinase and the other by the Ca2+-dependent activation of MLC kinase. These two pathways could be activated independ-ently of each other, depending on the type and ... rearrangements, by inhibiting actinassembly and focal adhesion in many cell types [8,9] through the decreased phosphorylation of various proteins [10,11]including MLC [12]. In a previous study of ... Ca2+mobilization and mediated by MLC kinase [3], and the other is Ca2+-independent, subsequent to the small GTP-binding protein RhoA activation, and mediated by Rho kinase [4–6]. The Ca2+/calmodulin-dependent...

Báo cáo y học: " Warfarin and fibrinolysis - a challenging combination: an observational cohort study" ppt

... collected the data and has involved in revising the manuscript. JB and TV have givenassistance to analysing the data and have revised the manuscript. HL hascontributed in collecting the data and ... City,Helsinki, Finland.3Department of Cardiology, Helsinki University CentralHospital of Meilahti, 00290 Helsinki, Finland.Authors’ contributionsSS has analysed the data and drafted the manuscript. ... bleeding, knowing the level of anticoagulation is valuable information.Some of the rapid point -of- care laboratory analysatorsused in ambulances have the capability to measure INR.This study is...

Báo cáo y học: "A web tool for finding gene candidates associated with experimentally induced arthritis in the rat" docx

... rating 2), SPINK5 (CGC points 14.2, CGCranking 4, manual rating 3), IK (CGC points 14.1, CGC rank-ing 5, manual rating 3) and CD14 (CGC points 12.8, CGCranking 6, manual rating 2). Two of these ... Council, the SWEGENE Foundation, the Sven and Lilly Lawski Founda-tion, the Royal Society of Arts and Sciences in Goteborg, the Wilhelm and Martina Lundgren Research Foundation and the Royal Hvitfeldtska ... monocytes/macro-phages and is centrally involved in the pathogenesis of RA and other inflammatory conditions.SLC26A2 (solute carrier family 26 member 2), CGC points 24.2, CGC ranking 2, manual rating 2SLC26A2...

Báo cáo y học: "Clinical observations on intensive immunosuppressive therapy combined with umbilical cord blood support for the treatment of severe aplastic anemia" ppt

... Zhe Yu, Yuan Fang and Fansheng KongAbstractObjective: To evaluate the efficacy of enhanced, intensive, immuno-suppressive therapy with umbilical cord bloodsupport for severe aplastic anemi ... total of 25 patients with SAA received enhanced, intensive, immuno-suppressive therapy and acord blood transfusion. Therapy protocol: Anti-thymocyte globulin (ATG) 2.5 mg/(kg•d) × 5d; Cyclophos ... Therefore, the toxic side effects of high-dose CTX (e.g., hemorrha-gic cystitis) can not be ignored. Intensive immunosup-pressive therapy, such as combined anti-thymocyteglobulin (ATG) and cyclosporine...

Báo cáo y học: "Cell cycle G2/M arrest through an S phase-dependent mechanism by HIV-1 viral protein R." pps

... densi-tometry was used to quantify the protein band and com-pared to either the protein loading control such as β-actinor the same protein at the baseline.Competing interests The authors declare ... activation of the cyclin-dependent kinase 1(Cdk1), which determines onset of mitosis in all eukary-otes [12-14]. Cdk1 is typically phosphorylated on Tyr15by Wee1 kinase in late G2 [13,15], and it ... within a single cell cycle. By using this single cellcycle assay, we have now uncovered that the G2-initiatingsignal(s) induced by Vpr is actually generated in the Sphase of the cell cycle through...

Báo cáo y học: "Differential cellular FGF-2 upregulation in the rat facial nucleus following axotomy, functional electrical stimulation and corticosterone: a possible therapeutic target to Bell’s pals" doc

... neurons and glial cells [5]. FGF- 2 protein and messenger RNA (mRNA) have been found in the cytoplasm of neurons and in thenucleiofastrocytesofmany brain regions [5-8]. FGF- 2 plays a role in the ... demonstrated increased synth-eses of the cytoskeletal proteins actin and tubulin afteraxotomy of the rat facial nerve simultaneously to the enhanced NF contents and a low regulation of NFsynthesis. ... crush and transection have promotedno changes in the number of the FGF- 2 immunoreactivity of neuronal profiles in the lesioned side (Figure 1B), the intensity of the FGF- 2 immunoreactivity increased...

Báo cáo y học: "Eotaxin-1 in exhaled breath condensate of stable and unstable asthma patients" pdf

... thank all the study participants.Author details1Department of Allergology and Internal Medicine, Medical University of Bialystok, Poland.2 The Teaching Hospital of the Medical University of Bialystok, ... patients and healthy volunteers were non-smokers and during the last year had not been passive smokers. The scheme of the procedures during the studyAfter inclusion to the study, the history of every ... Wiesbaden-Nordenstadt,Germany) in EBC were determined using an enzyme-linked immunosorbent assay. The minimum detectablelevel was 5.0 pg/ml.Statistical analysisStatistical significanc e was analyzed by using analysis...

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