Báo cáo y học: "How safe are the biologicals in treating asthma and rhinitis" doc

... Interleukin-13 Inhibition Interleukin-4 (IL-4) and Interleukin-13 (IL-13) are cytokines that play a role in allergic inflammation by inducing Th2 responses. Interleukin-4Rα is the signaling component of the ... authors concluded that there may be an increased risk of anaphy- laxis in asthmatic patients that may be dependent on the severity of asthma. Another variable and dif...

Ngày tải lên: 08/08/2014, 21:20

... (1994) Dioxygen-induced decarboxylation and hydroxylation of [Ni II (glycyl-glycyl- L -histidine)] occurs via Ni III : X-ray crystal structure o f [Ni II (glycyl-glycyl-a-hydroxy- D , L -histamine)]3H 2 O. J. ... modelling of C u(II) and Ni(II) transport by albumins. On the other hand, the direct thermodynamic and kinetic characterization of Ni(II) binding at site I in HSA and B...

Ngày tải lên: 22/02/2014, 04:20

... data and writing the paper. AL participated in the genetic and statistical analysis. HSA participated in designing the study, analysing the data and writing the paper. GB participated in designing ... designing the study, analysing the data and writing the paper. All authors read and approved the final manuscript. Competing interests The authors declare tha...

Ngày tải lên: 08/08/2014, 23:21

... contained the cDNA region coding for the N-terminal and MADS-box domain from one species and the region coding for the C-terminal domain from another species. Hybrid molecules were cloned in the ... extracts were analyzed by Western blotting using an antimyc antibody. The migration of the fusion proteins containing the myc epitope: human (HsSRF-myc), D. melanogaster (DmS...

Ngày tải lên: 22/02/2014, 07:20

... green since R G and R and G are the maximal red and green points under “ ”. Thus at least one of them, P say is yellow. Since the yellow points are decreasing and Y is the smallest yellow point ... meaning; for example, if R and W are red and white points we would have R W and W<R. Furthermore, the green and blue points are increasing, the red and yell...

Ngày tải lên: 07/08/2014, 06:22

... irritant-induced occupational asthma. Although such features of the history are sensitive indicators of occupational asthma, they are not specific and should therefore be followed by fur- ther investigations ... products used by the patient and by co-workers in the area can assist in obtaining these. However, MSDSs are designed to list toxic effects rather than hyper- se...

Ngày tải lên: 08/08/2014, 21:20

... of inducing synthesis of inflammatory cytokines such as IL-1β and TNF-α from host cells [13]. Whether the MMP induction in fibroblasts by S. aureus component(s) is due to the cytokine/chemokine ... osteomyelitis in murine models of these diseases. We therefore tested the ability of cell lysates and culture superna- tants obtained from these mutants and their isogenic parent st...

Ngày tải lên: 09/08/2014, 08:23

... directed toward the nuclear antigen RA-33 and heavy chain binding protein, both of which are found in early RA and pre-disease sera [29]. Antibody and T-cell reponses to heavy chain binding protein have ... be involved in the induction and maintenance of the proinflammatory cytokine cascade. Role played by B cells as antigen-presenting cells in rheumatoid arthritis B cel...

Ngày tải lên: 09/08/2014, 10:20

... probably including the synovium [8,11]. Furthermore DC, along with synoviocytes and macrophages, produce innate immune inflammatory mediators, and these mediators drive inflammatory pathology in ... uncharged carbonyl group, increasing the affinity of citrullinated proteins with the shared epitope. Fibrin and vimentin are two citrulli- nated proteins identified thus far in s...

Ngày tải lên: 09/08/2014, 10:20

... cellular interactions in the RA joint involving macrophages, T and B lymphocytes, and synovial fibroblasts. Laboratory investi- gations in vitro and in vivo have resulted in new findings about the role of the ... have primary roles in the inflammatory and catabolic processes in the joint, they may also promote cartilage damage, directly or indirectly. Despite th...

Ngày tải lên: 09/08/2014, 10:21