... above). The functional role of GIF synthesis and secretionin the brainTaken together, the regulation of GIF synthesis byreactive astrocytes, and its subsequent secretion undercertain conditions, ... is possible, then, that the up-regulation and secretion of GIF by astrocytes in the immediate vicinity of a lesion could contribute to the accumulation of reactive astrocytes at the injury site.Interestingly, ... aggregation is related to the genera-tion of ROS through the redox cycling of Cu. In thisregard, GIF has been demonstrated to not only preventAb aggregation, but also block the generation of ROSby...