... used1,4-dideoxy-1,4-imino-d-arabinitol (DAB), a potentinhibitor of phosphorylase and of glycogenolysis in hepatocytes with an IC50<2lm [33 ,34 ], which unlikeCP-91149, does not cause conversion of phophorylase-a ... experimental development. Biochem J286, 31 3 33 0. 38 Aiston S & Agius L (1999) Leptin enhances glycogenstorage in hepatocytes by inhibition of phosphorylase and exerts an additive effect with insulin. ... R6-mRNA levels and phos-phorylase activity in hepatocytes from Wistar rats. Hepatocytes werecultured for 18 h without or with 10 nM insulin (I) and ⁄ or 500 ngÆ mL)1leptin (L) . Parallel incubations...