... with the region that binds HR1 upon 6HB formation. The strong affinity of RC-101 for HR2 prevents the inter-action of HR1 and HR2, formation of the 6HB, and subsequent fusion of the host and viral ... mutations, one was found in gp120 and oneeach in the HR1 and HR2 regions of gp41, and all three mutations converted a polar or anionic residue toa cationic residue [14]. In addition, the cationic ... regions of gp41 [12]. During 100 days of serial passaging, HIV-1strain BaL developed three cationic mutations in the presence of sublethal concentrations of RC-101 [14]. Of the three mutations,...