... HSF1-activating reagents,17-allylamino-17-demethoxygeldanamycin (17-AAG) and geranylgeranylacetone (GGA), also ameliorated diseaseprogression in a Drosophila model of spinocerebellarataxias ... Waza M, Adachi H, Katsuno M, Minamiyama M,Sang C, Tanaka F, Inukai A, Doyu M & Sobue G(2005) 17-AAG, an Hsp90 inhibitor, amelioratespolyglutamine-mediated motor neuron degeneration.Nat ... dis-ease, Parkinson’s disease, amyotrophic lateral sclerosis,prion disease and polyglutamine diseases. These diseasesare characterized by conformational changes in disease-causing proteins that...