Báo cáo y học: " EGFR Expression in Gallbladder Carcinoma in North America" doc

... shown clinical efficacy in colon, [31, 32] and head and neck cancers. [31] Small molecules that target EGFR compete with ATP binding to the tyrosine kinase domain, thereby blocking sig- naling ... Systemic therapy for biliary tract can- cers. Oncologist, 2008. 13(4): 415-23. 3. Iyer R.V, et al. A phase II study of gemcitabine and capecitabine in advanced cholangiocarcinoma and carc...

Ngày tải lên: 08/08/2014, 17:20

... cysteine, and glycine, via two ATP-con suming s teps involving c-g lut- amylcysteine synthetase ( cGCS) and glutathione synthetase. The other constitutes a recycling system involving GR which reduces ... transit proteins during spermio- genesis, is rich in both arginine and cysteine. The cysteine sulfhydryls in protamine must form disulfide bond to package DNA into small sperm head during...

Ngày tải lên: 17/03/2014, 17:20

... lars.norderhaug@antibodydesign.com Abbreviations: IRES, internal ribosome entry site; SIgA, secretory IgA; pIgA, polymeric IgA; J-chain, joining chain; SC, secretory component; FITC, fluorescein isothiocyanate; ... the gene of interest is integrated into the chromosome by a nonhomologous recombination event [28,29]. This is a rare event and results in a very low frequency of integration and...

Ngày tải lên: 18/03/2014, 01:20

... changes in HAAP include marked proliferation of synoviocytes in the synovial lining layer, gross infiltration of lymphocytes, and migration of atypical lymphocytes with nuclear indentation into ... osteophytes and definite joint space narrowing. b Scoring was as follows: +/-, minimum staining in one area of the tissue; +, patchy staining involving several areas; ++, moderate diffuse s...

Ngày tải lên: 09/08/2014, 01:23

... polyclonal antibody recognizing lysyl oxidase (LOX) was used to identify cells synthesizing collagen and elastin [31]. LOX plays a cen- tral role in catalysing collagen cross-linking within the extracel- lular ... immunostaining was detected in the keratinocyte layers of the epidermis [38]. In all samples of dcSSc skin, there was a pronounced increase in Thy-1 staining throughout the...

Ngày tải lên: 09/08/2014, 07:20

... frequent [1], indi- cating a considerable influence of other pro-inflammatory cytokines beside TNF in perpetuating inflammation in RA. IL-15 has been identified as a pro-inflammatory cytokine of potential ... at baseline was correlated with a good response to therapy. Thus, in this study the synovial expression of IL-15 in RA was not consistently influenced by TNF blockade, being ap...

Ngày tải lên: 09/08/2014, 07:20

... 3 cystatins, the kininogens, are larger proteins containing three tandemly repeated type 2-like cystatin domains. Type 2 cystatins identified in higher animals include cystatins C, D, S, SA, and ... N-glycosylation motifs at positions 36–38 and 88–90 (cystatin C numbering). Recombinant cystatin F expressed in Sf9 insect cells is indeed glycosylated [5]. Compared to other cystatins, cystat...

Ngày tải lên: 21/02/2014, 01:21

... Naringenin-7-GlcRha (naringin) Hesperetin-7-GlcRha (hesperidin) Dihydrochalcones Phloretin-7-Glc (phlorizin) Secoiridoids Oleuropein Anthocyanidins Cyanidin-3-Glc (kuromanin) Cyanidin-3,5-diGlc Fig. ... M artinez-Ripoll, M., Lequerica, J.L. & Polaina, J. (1998) Crystal structure of beta- glucosidase A from Bacillus polymyxa: insights into the catalytic activity in family 1 glycosyl hydr...

Ngày tải lên: 08/03/2014, 16:20

... inflammatory process in allergic rhinitis (AR) involves many different inflammatory cells, cytokines, chemokines and other regulatory molecules [1]. It is well known that exposure to allergens, including ... is an increased scientific interest in the putative role of OPN in several diseases, including asthma, allergy and rhinosinusitis [7,10,14,15]. In the current study, we have obser...

Ngày tải lên: 08/08/2014, 21:20

... of interleukin-1-beta (IL-1β) on lipocalin-type prostaglandin D synthase (L-PGDS) expression in osteoarthritis chondrocytesEffect of interleukin-1-beta (IL-1β) on lipocalin-type prostaglandin ... Hirawa N, Uehara Y, Yamakado M, Toya Y, Gomi T, Ikeda T, Eguchi Y, Takagi M, Oda H, Seiki K, Urade Y, Umemura S: Lipocalin-type prostaglandin d synthase in essential hypertension. Hyperten-...

Ngày tải lên: 09/08/2014, 01:22