Báo cáo y học: "A 12 Week, Open Label, Phase I/IIa Study Using Apatone® for the Treatment of Prostate Cancer Patients Who Have Failed Standard Therapy" pps
... capsule every two
hours for six doses followed by two capsules at
bedtime for a total of ten capsules per day. Following
the 12 week study, two of the three “non-responders”
in the study who had ... options for androgen independent prostate
cancer (AIPC) patients. Therefore, there is a substantial
need for new therapeutic options.
Because of their relative...
... diseases), with the written informed con-
sent of patients for diagnostic or clinical purposes. Patients
with present pulmonary infections were excluded from the
study. The study was approved by the local ... immunosuppressive therapies. Another limi-
tation of the study is the low number of patients and the heter-
ogeneity of the control group.
In conclus...
... instability criteria
of kyphotic deformity of more than 20° and/or vertebral
body height loss of more than 50 compared to vertebra
below. The senior author (KJC) performed all surgeries. At
surgery, the ... and early mobilization for burst fractures of
the thoracolumbar junction. Eur Spine J 1996, 5: 112- 120.
21. Cho DY, Lee WY, Sheu PC:
Treatment of thoracolumbar burst
f...
... randomized,
double-blind, placebo-controlled, study of the efficacy and safety of
aripiprazole 10, 15 or 20 mg/day for the treatment of patients with
acute exacerbations of schizophrenia. J Psychiatr Res 2007, 41(11):895-905.
15. ... the
prestudy medication.
Safety and tolerability
Of the 245 subjects who were included in the safety
sample, 163 (66.5%) experience...
... depicted as the percentage of the body weight at the time of AA induction. Data shown are the percentage of the body weight of two
experiments (n = 10 rats per group) ± standard error of the mean. ... observed.
Discussion
In the present study, we explored the possibility of using
recently identified MMP T-cell epitopes for immunotherapy
in AA. First, we moni...
... of Cancer Cell Biology of the 1
st
Faculty of Medicine, Charles University, Prague and the Institute of Physiology, Academy of Sciences,
Prague, Czech Republic
2
Department of Medical Oncology, ... difference in DPPIV activity in the sera of RA
patients compared to the normal controls, but the study
groups in this report were not delineated by disease severity,
t...
... develop OA sponta-
neously; therefore, they can be used as a model of primary OA.
In STR/ort mice, OA progresses relatively slowly. Therefore,
we examined the final result of TGF-β and Smad7 overexpres-
sion ... histological analysis of synovial fibrosis and PG content of
the cartilage.
Histology
Knee joints of mice were dissected and fixed in phosphate-
buffered formalin for...
... membranes of RA
patients, because the sensitivity of in situ hybridization is lim-
ited [50]. In the previous study, the synovial lining cells of RA
patients were stained by the anti-IL-32 antibody [16]. ... in the synovial tissues of RA patients by in situ
hybridization (Figure 2a). We detected abundant IL-32 expres-
sion in the synovial-infiltrated lymphocytes of...
... [16]. Although
these techniques are valuable for the understanding of the
contribution of local antibody synthesis to the pathogenesis of
RA, their applicability in interventional biopsy-based clinical ... study.
The other authors declare that they have no competing
interests.
Authors' contributions
SR participated in the design of the study, developed and per-...
... unacceptable toxicity; however, the vast majority of
patients will have some combination of the two, which will
hamper a clear adjudication of the reason for withdrawal.
In summary, the study by Saad and ... the
methodology of looking at all treatment terminations and then
at only those terminations for the reason of ineffectiveness
and terminated for the...