... glycoside, streptomycin, t hepenicillins, ampicillin and penicillin G, the aminocyclitol,spectinomycin, tetracycline and Cl-tetracycline, and themacrolide, erythromycin) on n uclear b-globin ... splicing inhibition by tetracycline is n egligible (Fig. 2). The sixfold stron gersplicing inhibition by Cl-tetracycline may be explained by the a dditional s ize and hydrophobicity introduced by thesubstitution, ... describedpreviously [ 31] .RESULTSErythromycin, Cl-tetracycline and streptomycin inhibitnuclear splicing in vitroThe effects of eight different antibiotics (the aminoglycoside,kanamycin, the a minocyclitol...