... evaluate theirpotential role in CFTR expression.Noncytotoxic doses of mitomycin C, a DNA cross-linking reagent have been shown to preferentially alter theexpression of inducible genes [19]. Mitomycin ... Genetics, Institute of Molecular Medicine, Oxford University, John Radclie Hospital, UK;2Center for Biological Sequence Analysis, Biocentrum DTU, Technical University of Denmark, Lyngby, DenmarkThe ... DHS in regulation of CFTR expres-sion. The ®rst series of experiments evaluated potentialenhancer activity of the intragenic DHS in transienttransfection of reporter/enhancer constructs. We haveshown...