NEUROVASCULAR MEDICINE - Pursuing Cellular Longevity for Healthy Aging Part 9 ppsx

... p38 MAPK activa- tion/↑ c-Fos, c-Jun and JunB expression, ↑AP-1 activity Mitogenesis associated with atherosclerosis, aging, or cancer Rao et al. 199 9 ↑ROS-RNS/↑AP-1 activity/↑MMP-2/cardiac remodeling Response ... Benson JM, Henderson RF. 198 5. Effects of the long-term depletion of reduced glu- tathione in mice administered L-buthionine-S, R-sulfoximine. Fundam Appl Toxicol. 5(5) :91...

Ngày tải lên: 08/08/2014, 13:21

... al. 199 4 Haller et al. 199 4 Singer 199 0 Ohanian et al. 199 6 Kanashiro 2000 Watanabe 198 9 β 80–82 Rat aorta Carotid artery Cytosolic Cytosolic Nuclear Membrane Haller et al. 199 4 Singer 199 0 γ ... (ATP )- and substrate-binding sites. All PKC subspecies contain the ATP-binding sequence, Gly-X-Gly-X-X-Gly Lys, which is observed in most protein kinases (Fig. 2.2) (Nishizuka 199 2; N...

Ngày tải lên: 08/08/2014, 13:20

... Lechin et al. 199 3, 199 7a Lechin, van der Dijs 2006a Non–essential hypertension X Lechin et al. 199 7a Respiratory disorders Acute asthma X Lechin AE et al. 199 4 Lechin et al. 199 6f, 199 8b; Lechin ... IL-18, γ-interferon) (Madden, Felten, Felten et al. 198 9; Ader, Felten, Cohen 199 0; Madden, Felten, Felten et al. 199 4; Amital, Blank, Shoenfeld 199 6; Nicholson, Kuchroo 199 6; Aula...

Ngày tải lên: 08/08/2014, 13:20

... CM COS-7 cells COS-7 CM HFF cells HFF CM K-562 cells K-562 CM U-373 cells U-373 CM SK-N-BE cells SK-N-BE CM SH-SY5Y cells SH-SY5Y CM CHP-100 cells CHP-100 CM Chapter 16: Proteases in 𝛃 -Amyloid ... Platelet- derived growth factor induces the beta-gamma- secretase-mediated cleavage of Alzheimer’s amyloid precursor protein through a Src-Rac-dependent path- way. J Biol Chem. 278 :92 90 92 97....

Ngày tải lên: 08/08/2014, 13:20

... (Mellergard, Nordstrom 199 0; Mariak, Lewko, Luczaj et al. 199 4; Mariak, Jadeszko, Lewko et al. 199 8; Rumana, Gopinath, Uzura et al. 199 8; Mariak, Lebkowski, Lyson et al. 199 9; Mariak, Lyson, Peikarski ... vas- orelaxation factors. It is likely that ET-1 levels in the 199 4; Bakken, Vincent, Sjaavaag et al. 199 5; Stowe, O’Brien, Chang et al. 199 7) on normal ocular cir- culations...

Ngày tải lên: 08/08/2014, 13:20

... AND DISABILITY 168 forebrains have been characterized (Zhuo, Gebhart 199 0a, 199 0b, 199 1, 199 2, 199 7; Calejesan, Kim, Zhuo 2000). Biphasic modulation of spinal nociceptive trans- mission from the ... neuronal thresh- old to nociceptive stimulation (Zhuo, Gebhart 199 0a, 199 0b, 199 1, 199 2, 199 7). Descending facilitation has a general impact on spinal sensory transmission, induc-...

Ngày tải lên: 08/08/2014, 13:20

... Fike et al. 199 9). Low-dose, whole-brain, X-ray irradiation in adult rats inhib- its dentate granule cell neurogenesis (Tada, Parent, Lowenstein et al. 2000). Low-dose, whole-brain, X-ray irradiation ... glutamate receptor agonists at 100 µM for 12 consecutive days, followed by deter- mination of mitochondrial activity with 3-( 4, 5- dimethyl-2-thiazolyl )-2 ,5-diphenyl-2H-tetra...

Ngày tải lên: 08/08/2014, 13:20

... provide co-stimulatory sig- nals for T-cell activation and that are represented VCAM-1 VLA-4 B7 CD40 MHC-II CD3 TCR CD4 LFA-1ICAM-1 LFA-3 Ag CD40L CD28 CD2 VCAM-1 VLA-4 B7 CD40 MHC-I CD3 APC APC A B CD8 + CD4 + TCR CD8 LFA-1ICAM-1 LFA-3 Ag CD40L CD28 CD2 Figure ... ammatory mediators) Wood 199 5; Zhang et al. 199 7; Schroeter et al. 199 7; Yrjaneheikki et al. 199 8, 199 9; Zhang et al....

Ngày tải lên: 08/08/2014, 13:20

... interleukins, IL-1, IL-6, and IL-10, transforming growth factor-α (TGF-α), and TNF-α. Among those cytokines, IL-1 and TNF-α appear to exacerbate cerebral injury; how- ever, IL-6, IL-10, and TGF-α may ... Neurosurg. 96 : 892 – 899 . Schwaninger M, Inta I, Herrmann O. 2006. NF-KappaB signalling in cerebral ischaemia. Biochem Soc Trans. 34:1 291 –1 294 . Seki T, Arai Y. 199 5. Age-related...

Ngày tải lên: 08/08/2014, 13:20

... 37 β-PKC, 29, 30, 33, 37 δ-PKC, 26, 28, 29, 31, 34, 36, 37, 38 ε-PKC, 25–26, 28, 29, 30, 33, 34, 35 γ-PKC, 24, 26–27, 29, 34 η-PKC, 25–26 θ-PKC, 25 ξ-PKC, 26–27, 30, 33, 34, 35, 36 PKCβI, 24, 29, ... nephropathy (Ziyadeh, Goldfarb 199 1; Lane, Steffes, Fioretto et al. 199 3; Taft, Nolan, Yeung et al. 199 4; Jones, Saunders, Qi et al. 199 9; Gilbert, Cooper 199 9). Such tubular changes ha...

Ngày tải lên: 08/08/2014, 13:21