NEUROVASCULAR MEDICINE - Pursuing Cellular Longevity for Healthy Aging Part 8 pps

... interleukins, IL-1, IL-6, and IL-10, transforming growth factor-α (TGF-α), and TNF-α. Among those cytokines, IL-1 and TNF-α appear to exacerbate cerebral injury; how- ever, IL-6, IL-10, and TGF-α may ... inducible CD 18/ 11α(LFA-1, αLβ2) VCAM-1 Endothelium, constitutive and inducible CD 18/ 11β(Mac-1, αMβ2) VLA-4 (α4β1) Integrins CD 18/ 11α(LFA-1, αLβ2) Neutrophils/macrophages, constitut...

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... PS DAG Choline GTP IP 3 RhoA Ca 2+ CaM MLCK active inactive MLCK MLC-P MLC MLC Phosphatase Rho-kinase CPI-17 CPI-17-P MYOSINACTIN CONTRACTION MAPK GDP PKC PKC SR MEK CaP-P Actin-CaP Actin-CaD CaD-P Actin Raf lipase ADP ATP P i Figure 2.1 Cellular mechanisms ... from crip- pling degenerative disorders. With this objective, Neurovascular Medicine: Pursuing Cellular Longevity for H...

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... with TH-2 immunolog- ical pro le, which is caused by low CD4/CD8 ratio, low NK-cell cytotoxicity against K-562 target cells, and low plasma levels of TH-1 cytokines (IL-2, IL-12, IL- 18, γ-interferon) ... Azócar et al. 1 988 c; van der Dijs, Lechin, Vitelli et al. 1 988 a; van der Dijs, Lechin, Vitelli et al. 1 988 b; Vitelli, Lechin, Cabrera et al. 1 988 ; Lechin S Vitelli, Martinez e...

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... CM COS-7 cells COS-7 CM HFF cells HFF CM K-562 cells K-562 CM U-373 cells U-373 CM SK-N-BE cells SK-N-BE CM SH-SY5Y cells SH-SY5Y CM CHP-100 cells CHP-100 CM Chapter 16: Proteases in 𝛃 -Amyloid ... activity IL-6 TGF-β IL-10 Phospholipid release from LDL Chemokines TNF-α, IL-1 NOVEL CELLULAR PATHWAYS 394 for compounds isolated from ginseng, which is used in traditional Asian medicine...

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... 94(26):14 483 –14 488 . Palmer LA, Gaston B, Johns RA. 2000. Normoxic stabiliza- tion of hypoxia-inducible factor-1 expression and activ- ity: redox-dependent effect of nitrogen oxides. Mol Pharmacol. 58( 6):1197–1203. Pan ... and p 38 MAPK activa- tion/↑ c-Fos, c-Jun and JunB expression, ↑AP-1 activity Mitogenesis associated with atherosclerosis, aging, or cancer Rao et al. 1999 ↑ROS-R...

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... brain levels of Evans blue (2. 8- and 5-fold increase vs. control), as well as a strong immunoreactivity for albumin and GFAP (3 6- and 83 -fold increases and 5- to 12-fold increases vs. control, ... ˚C 2.5 2.0 1.5 1.0 0.5 –0.5 –40 Hippo Muscle Hippo-muscle NAcc-muscle NAcc –40 04 080 04 080 –0.1 0.0 0.1 0.2 0.3 0.4 0.5 0.6 0.7 –0.2 43 42 41 40 39 38 37 36 35 –60 0 60 120 T...

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... insulin and of IGF-1, whose effective activity is increased in the context of IR to boost activity of the transcription factor hypoxia-in- ducible factor- 1- (HIF- 1- ), may be at least partially responsible ... direct evidence for a contribution of the anterior cingulated cortex. Proc Natl Acad Sci U S A. 98: 8077 80 82. Jones EG, Pons TP. 19 98. Thalamic and brainstem contribu- t...

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... glutamate receptor agonists at 100 µM for 12 consecutive days, followed by deter- mination of mitochondrial activity with 3-( 4, 5- dimethyl-2-thiazolyl )-2 ,5-diphenyl-2H-tetrazolium bromide (MTT) reduction ... (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) (Zhao, Momma, Delfani et al. 2003). Another study reports no evidence of new dopaminergic neurons in the SN of 6-hydroxyd...

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... provide co-stimulatory sig- nals for T-cell activation and that are represented VCAM-1 VLA-4 B7 CD40 MHC-II CD3 TCR CD4 LFA-1ICAM-1 LFA-3 Ag CD40L CD 28 CD2 VCAM-1 VLA-4 B7 CD40 MHC-I CD3 APC APC A B CD8 + CD4 + TCR CD8 LFA-1ICAM-1 LFA-3 Ag CD40L CD 28 CD2 Figure ... molecules Selectins, integrins Up-regulated All reviewed in Wang et al. 2007 Cytokines IL-1, TNF-α, IL-6, IL-10, TGF-β Che...

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... 133 Disul de formation, 479 bond formation, 477, 479, 480 f, 482 , 483 , 488 DJ-1 mutations, 464 DL-α-amino-3-hydroxy-5-methyl- 4-isoxasolepropionate receptor (AMPAR), 270 DM20, 355 DNA-damaged inducible ... deposition, 6–7, 13, 388 Amyloid precursor protein (APP), 370, 373 β-amyloid peptides (Aβ), 388 –390 cathepsin B and, 388 deletion of, effects, 386 functions, 386 processing, 38...

Ngày tải lên: 08/08/2014, 13:21