NEUROVASCULAR MEDICINE - Pursuing Cellular Longevity for Healthy Aging Part 5 pdf

Ngày tải lên: 23/12/2013, 11:15

... completed its planned new capital, Abuja. Both Brazil and Malaysia have found that the building of new capitals (Brasilia and Putrajaya) can sharply increase the national burden of debt. Even ... reported that baboons are able to think abstractly. It has been known for some time that chimpanzees are capable of abstract thought, but baboons are a more distant relation to mankind. In...

Ngày tải lên: 24/12/2013, 05:15

... University Press. Library of Congress Cataloging-in-Publication Data Neurovascular medicine: pursuing cellular longevity for healthy aging / [edited by] Kenneth Maiese. p. ; cm. Includes bibliographical ... â 2009 by Oxford University Press, Inc. Published by Oxford University Press, Inc. 198 Madison Avenue, New York, New York 10016 www.oup.com Oxford is a registered trademark...

Ngày tải lên: 11/06/2014, 10:12

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Ngày tải lên: 21/07/2014, 22:20

... PS DAG Choline GTP IP 3 RhoA Ca 2+ CaM MLCK active inactive MLCK MLC-P MLC MLC Phosphatase Rho-kinase CPI -1 7 CPI -1 7 -P MYOSINACTIN CONTRACTION MAPK GDP PKC PKC SR MEK CaP-P Actin-CaP Actin-CaD CaD-P Actin Raf lipase ADP ATP P i Figure 2 .1 Cellular mechanisms ... Mercadante et al. 2007. 51 90 10 5 11 9 12 8 14 4 17 2 17 9 19 2 COOH Laminin NCAM Laminin receptor 37/67 kDa p75...

Ngày tải lên: 08/08/2014, 13:20

... ˚C 2. 5 2. 0 1.5 1.0 0.5 –0.5 –40 Hippo Muscle Hippo-muscle NAcc-muscle NAcc –40 04080 04080 –0.1 0.0 0.1 0 .2 0.3 0.4 0.5 0.6 0.7 –0 .2 43 42 41 40 39 38 37 36 35 –60 0 60 120 Time, min 180 24 0 ... concentration, mg%; (D) numbers of albumin- and GFAP-positive cells). All values (4 for control, 8 for METH 23 °C, and 8 for METH— 29 °C, a total n = 20 ) were accepted for this...

Ngày tải lên: 08/08/2014, 13:20

... (γ-interferon, IL-2, IL-12, IL-18, TNF, etc.). On the contrary, enhanced corti- sol level inhibits the thymus gland and increases the plasma values of TH-2 cytokines (IL-4, IL-6, IL-10, β-interferon, ... with TH-2 immunolog- ical pro le, which is caused by low CD4/CD8 ratio, low NK-cell cytotoxicity against K-562 target cells, and low plasma levels of TH-1 cytokines (IL-2, IL-12, IL-18,...

Ngày tải lên: 08/08/2014, 13:20

... insulin and of IGF-1, whose effective activity is increased in the context of IR to boost activity of the transcription factor hypoxia-in- ducible factor- 1- (HIF- 1- ), may be at least partially responsible ... Alford F, Best JD. 1996. Low density lipoprotein particle size in hypopi- tuitary adults receiving conventional growth hor- mone replacement therapy. J Clin Endocrinol Metab....

Ngày tải lên: 08/08/2014, 13:20

... glutamate receptor agonists at 100 àM for 12 consecutive days, followed by deter- mination of mitochondrial activity with 3-( 4, 5- dimethyl-2-thiazolyl )-2 , 5- diphenyl-2H-tetrazolium bromide (MTT) reduction ... Neurologist. 13(3):1 05 117. Raber J, Huang Y, Ashford JW. 2004. ApoE genotype accounts for the vast majority of AD risk and AD pathol- ogy. Neurobiol Aging. 25( 5):...

Ngày tải lên: 08/08/2014, 13:20

... provide co-stimulatory sig- nals for T-cell activation and that are represented VCAM-1 VLA-4 B7 CD40 MHC-II CD3 TCR CD4 LFA-1ICAM-1 LFA-3 Ag CD40L CD28 CD2 VCAM-1 VLA-4 B7 CD40 MHC-I CD3 APC APC A B CD8 + CD4 + TCR CD8 LFA-1ICAM-1 LFA-3 Ag CD40L CD28 CD2 Figure ... Wang et al. 2007 Cytokines IL-1, TNF-α, IL -6 , IL-10, TGF-β Chemokines IL-8, IP-10, MCP-1, MIP-1α Transcriptional regulators...

Ngày tải lên: 08/08/2014, 13:20

... CM COS -7 cells COS -7 CM HFF cells HFF CM K-562 cells K-562 CM U- 373 cells U- 373 CM SK-N-BE cells SK-N-BE CM SH-SY5Y cells SH-SY5Y CM CHP-100 cells CHP-100 CM Chapter 16: Proteases in 𝛃 -Amyloid ... measured in a γ-counter. Fraction No A: Non-neuronal cells B: Neuronal cells 5 0 7 14 0 7 14 0 7 14 0 7 PI PII PI PII A A CPMì10 3 CPMì10 3 CPMì10 3 CPMì10 3 14 0 7 14 0 7 14 0...

Ngày tải lên: 08/08/2014, 13:20

... interleukins, IL-1, IL-6, and IL-10, transforming growth factor-α (TGF-α), and TNF-α. Among those cytokines, IL-1 and TNF-α appear to exacerbate cerebral injury; how- ever, IL-6, IL-10, and TGF-α may ... inducible CD 18/ 11α(LFA-1, αLβ2) VCAM-1 Endothelium, constitutive and inducible CD 18/ 11β(Mac-1, αMβ2) VLA-4 (α4β1) Integrins CD 18/ 11α(LFA-1, αLβ2) Neutrophils/macrophages, constitut...

Ngày tải lên: 08/08/2014, 13:20

... p38 MAPK activa- tion/↑ c-Fos, c-Jun and JunB expression, ↑AP-1 activity Mitogenesis associated with atherosclerosis, aging, or cancer Rao et al. 199 9 ↑ROS-RNS/↑AP-1 activity/↑MMP-2/cardiac remodeling Response ... Benson JM, Henderson RF. 198 5. Effects of the long-term depletion of reduced glu- tathione in mice administered L-buthionine-S, R-sulfoximine. Fundam Appl Toxicol. 5(5) :91...

Ngày tải lên: 08/08/2014, 13:21

... signaling pathways in, 551 Amadorins, 527, 529t γ-Amino butyric acid (GABA), 104 , 156, 270 Aminoguanidine, 526, 530 α-Amino-3-hydroxy-5-methyl- 4-isoxazole propionate (AMPA) receptors, 155, 158, ... (DSA), 512 Dihydroergotamine, 122, 131, 132, 133f 3,5-dihydroxyphenylglycine (DHPG), 273 3-( 4,5-dimethyl-2-thiazolyl )-2 ,5-diphenyl - 2H-tetrazolium bromide (MTT), 273 Dipeptidyl...

Ngày tải lên: 08/08/2014, 13:21