... understood. Because of this,assessment of potential immunotoxic effects of drugs, chemicals, and other agents is not a simple task.Often, measurement of a variety of components of the immune system ... and expression of antibodies to self-tissue, including nuclearmacromolecules. Studies of drug-related autoimmunity in humans have provided some of the bestexamples of this type of reaction. Although ... to support any of these, and many explanations arecontrary to current understanding of immunology and toxicology; (4) objective evidence of anychemical agent as a specific cause of multiple chemical...