Báo cáo khoa học: "Bioavailability of the amino acid-attached prodrug as a new anti-HIV agent in rats" pdf

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Ngày tải lên: 07/08/2014, 23:22

... cleaved by elastase to release a 75 kDa fragment and by calpain, at a site near the cell membrane, to generate an 82 k Da fragment [12]. Despite its association with the other subunits of the ... complex, allowing study of its biosynthesis and cellular distributio n. Experimental procedures Materials and cell lines The mAbs V.1 and V.5 ag ainst GPV, ALMA.12 against GPIba, ALMA...

Ngày tải lên: 23/03/2014, 13:20

... restricted areas before a limited number of bacteria gain access to integrins and inject CagA. The basal injection model of CagA can also explain why H. pylori does not cause more gastric damage in infected ... CagA in a phosphorylation-dependent fashion: the tyrosine phos- phatases Shp1, the adaptor proteins Grb2, Grb7 and Crk, phosphoinositide-3-kinase, Ras GTPase activati...

Ngày tải lên: 14/02/2014, 19:20

... promoters indicate the a- F1-ATPase GAF/Adf-1 binding cassette has enhancer properties. (A) The basal promoter activity of b-F1-ATPase is greatly increased when the a- F1-ATPase GAF/Adf-1 binding cassette ... increase of promoter activity independent of the orientation. This increase was sevenfold in the case of the ALAS promoter and reached 10-fold in the b-F1- AT...

Ngày tải lên: 07/03/2014, 16:20

... except that a 0.1 M borate buffer (pH 9.7) was used. Leucine (20 l M )was added as an internal standard. After a 2 min incubation at room temperature, the reaction mixture was separated on a Hewlett-Packard ... DW )1 was assumed [24]. Analysis of methanofuran and formyl-methanofuran Cell samples were anaerobically divided into two parts. One portion was kept cold, while the othe...

Ngày tải lên: 17/03/2014, 09:20

... intestines from the auto- mated stapler. The abdomen was again inflated and the lifted jejunum was led into the abdominal cavity. Connection with anvil, and anastomosis The anvi l and the main unit ... cm away from the ligament of Treitz was led from a small abdominal incision to outsi de the abdominal cavity and also cut off with an automated stapler. An automated stapler...

Ngày tải lên: 09/08/2014, 01:24

... was amplified using oligonucleotides FNRC266L (5¢-GACAA CACTTTTGTCTACATGTTGGGACTGAAAGG-3¢)or FNRC266M (5¢-GACAACACTTTTGTCTACATGATGG GACTGAAAGG-3¢) and FNRlw1 (5¢-GTAATCTATCTA CAGAATACAGGAGGGTGATA-3¢) ... with the amino acid arrangement observed in the catalytic site, indicate that C266 may constrain the nicotinamide and or the terminal tyrosine against the flavin. It has been desc...

Ngày tải lên: 18/02/2014, 17:20

... suggesting that there was little contamination from xylem, and vice versa. Glx (glutamine and glutamate: five carbon amide and amino acid) and Asx (asparagine and aspartate: four carbon amide and amino ... -FNR 1 (AB035644): forward primer, 5¢-ACAACACAAAATGTCAGCTGC AAAA-3¢; reverse primer, 5¢-AAGGCCAAGAAGGAGTC CAAGAAG-3¢; L-FNR 2 (AB035645): forward primer, 5¢-TTGCTTGAGCTGAACAATACAATGAA-3¢...

Ngày tải lên: 18/02/2014, 18:20

... both l -amino acids and d -amino acids at the correct locus in order to predict when and where d -amino acids may be found post-translationally in polypeptide chains. The I-conotoxins are a large and ... noted by Kauferstein et al. [11], another characteristic of the I 2 superfamily is that a small region at the C-terminus is proteolytically excised. Thus, all of the...

Ngày tải lên: 16/03/2014, 22:20

... species, was not surprising as seawater is regularly contaminated with sewage, even in the best of times and that also in resort areas. Inland freshwa- ter pools classically contain Gram-negative bacilli ... and management as routinely performed on incoming patients, including rapid stabilization of vital parameters, phys- ical and neurological examination, radiography and labor...

Ngày tải lên: 25/10/2012, 10:41