... restricted areas before a limited number of bacteria gain access to integrins and inject CagA. The basal injection model of CagA can also explain whyH. pylori does not cause more gastric damage in infected ... CagA in a phosphorylation-dependent fashion: the tyrosine phos-phatases Shp1, the adaptor proteins Grb2, Grb7 andCrk, phosphoinositide-3-kinase, Ras GTPase activatingprotein RasGAP, and as ... several adhesins such as BabA, BabB, SabA, AlpA and AlpB, as well as OipA, which mediate apical binding of the bacteria (1).Attached H. pylori or those in the mucus secrete virulence factors into...