... position of the intact His- tagged H1 receptor is indicated by the arrow. The quantity of the remaining minor contaminating bands in the purified receptor varied between preparations. Their identity ... structure and receptor–ligand interactions of the histamine receptors. Elucidation of the structure and dynamics of membrane proteins is a challen- ging task essen...
Ngày tải lên: 30/03/2014, 14:20
... Because the activity on X 6 remains the same upon engineering of the SBS of XBS, the results obtained in the previous screening experiment directly Table 1. The effect of genetic engineering of the ... obtained in the present study, it might be speculated that SBS is involved in targeting the enzymes towards their sub- strate and, subsequently, in anchorin...
Ngày tải lên: 14/02/2014, 19:20
Báo cáo khoa học: Cas utilizes Nck2 to activate Cdc42 and regulate cell polarization during cell migration in response to wound healing docx
... pipette tip and incubated for 24 h. Data are the mean ± SD of the distance that leading edge of the monolayer traveled into the wound area in five randomly selected fields from three independent ... protein that mediates integrin sig- naling leading to cell migration, in cell polarization. In the present study, we found that Cas was essential for the polarization...
Ngày tải lên: 23/03/2014, 03:20
Báo cáo khoa học: Context-dependent effects of proline residues on the stability and folding pathway of ubiquitin docx
... xtent of structure formation within the main a-helix (residues 24–33), and examine the integrity o f the helix C-capping motif and of the s hort helix (residues 3 8–40). In ubiquitin, the C-capping ... to the side chains of Lys27 and Gln31 in the main a-helix are also evident and confirm t hat the Ala38 methyl g roup occupies the same hydrophobic pocket as...
Ngày tải lên: 07/03/2014, 16:20
Báo cáo khoa học nông nghiệp " Effects of Stocking Biomass on Growth, Survival and Production of the Two Sizes of Clam Meretrix lyrata Cultured in the Intertidal Areas And Notes on Hatchery Production of Clam Spat " pot
... of the clam was significant increased as increasing of stocking biomass (p<0.05). The percentage of biomass gained, in contrast, was reduced as increasing of stocking biomass in T5, T6 and ... difference (p>0.05) in the biomass gained in the treatment T5 and T6 nor percentage of biomass gained in the treatments T7 and T8. In both size groups, the...
Ngày tải lên: 21/06/2014, 05:20
Báo cáo khoa học: " Dose-Incidence Relationships on the Prenatal Effects of Gamma-Radiation in Mice" pdf
... length was measured from the tip of the snouttothebaseofthetail.Thelongitudinaldistancefrom thetipofthesnouttothebaseoftheskullwasrecorded as head length. The distance between the two ears was recorded ... the organs undergoing differentiation at the time of the irradiation, the stage of differentiation and the radiation dose [1]. The effect of irradiation during...
Ngày tải lên: 07/08/2014, 15:20
Tài liệu Báo cáo khoa học: Stefin A displaces the occluding loop of cathepsin B only by as much as required to bind to the active site cleft doc
... with chagasin and stefin A shows that the magnitude of the shift of the occlud- ing loop is related to the size of the binding region. It is smallest in the procathepsin structures and increases in the ... features of the ligands that compete with the occluding loop for binding to the active site, the farther away the occluding loop residues are shif...
Ngày tải lên: 18/02/2014, 04:20
Tài liệu Báo cáo khoa học: Branched N-glycans regulate the biological functions of integrins and cadherins doc
... the regulation of integrin function. Therefore, we speculate that modifi- cation of particular sites, which are involved in regula- tion of the conformation of integrin, determine the extent of ... suppressed by the upregulation of GnT-III. In fact, the results of several studies suggest that E-cadherin can induce ligand-independent activation of EGFR and su...
Ngày tải lên: 18/02/2014, 17:20
Tài liệu Báo cáo khoa học: Chemical approaches to mapping the function of post-translational modifications ppt
... acute and chronic in ammation in mammalian brain tissue both in vitro and in vivo, including in the detection of cerebral malaria. Retooling of this reporter system also allowed sys- tematic investigation ... suggests that neu- rons display selective GlcNAc-binding proteins, an intriguing result in the light of previous work on the proposed role of GlcNAc regard...
Ngày tải lên: 18/02/2014, 17:20
Tài liệu Báo cáo khoa học: Rotary F1-ATPase Is the C-terminus of subunit c fixed or mobile? docx
... suggested the unwinding of the single a-helix at the C-terminal portion of c, thus allowing for unimpaired rotation of the remainder of c.Furthermore, the calculations suggested the very end of c ... revealed the possibility of a ‘functional unwinding’ of the a-helix to form a swivel joint. Furthermore, they suggested a firm clamping of that part of c even w...
Ngày tải lên: 19/02/2014, 16:20