Báo cáo khoa học: "Disposition kinetics and urinary excretion of cefpirome after intravenous injection in buffalo calves" doc

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Báo cáo khoa học: "Disposition kinetics and urinary excretion of ciprofloxacin in goats following single intravenous administration" doc

... kinetics and urinary excretion of ciprofloxacin in goats following single intravenous administration 243Tabl e 2 . Urinary excretion of ciprofloxacin and fraction of the dose (%) excreted in ... Disposition of ciprofloxacin following intravenous administration in dogs. J Vet Pharmacol Ther 1994, 17, 384-388.2. Albarellos GA, Kreil VE, Landoni MF. Pharmacokinetics of ciprofloxacin after single ... extent of protein binding was determined in vitro using an equilibrium dialyzing technique as described by Kunin [18]. To estimate the protein binding of ciprofloxacin, the drug was dissolved in...

Báo cáo khoa học: "Disposition kinetics and dosage regimen of levofloxacin on concomitant administration with paracetamol in crossbred calves" potx

... re-ported after intravenous administration of levofloxacin alone in calves [13]. However, in contrast to our findings, a long t1/2α of 19 h was reported after intravenous admin-istration of enrofloxacin ... of 0.21 l/kg/h and 0.32 l/kg/h after a single intra-muscular [12] and intravenous [13] administration of levo-floxacin without paracetamol and 0.28 l/kg/h reported for enrofloxacin after intravenous ... distribution of levofloxacin, when administered alone by single intravenous injection, to be 0.74 l/kg in calves and 0.94 l/kg in man. However, the volume of distribution of other fluoroquinolones...

Báo cáo khoa học: Puriﬁcation and functional characterization of human 11b hydroxylase expressed in Escherichia coli doc

... volume and energeticproperties of the binding of CO to hemoproteins.Biophys J 66, 89–98.42 Tuckey RC & Kamin H (1983) Kinetics of O2 and COBinding to adrenal cytochrome P-450scc. Effect of ... beexplained by the broader substrate-binding spectrum of bCYP11B1 resulting from the combination of thefunctions of CYP11B1 and CYP11B2 within oneenzyme.Comparison of the kcatvalues obtained ... in therange of values determined in previous studies for theinteraction between bovine Adx and bCYP11B1.Biacore measurements were performed to investigatethe binding behavior between bovine...

Tài liệu Báo cáo khoa học: Computational processing and error reduction strategies for standardized quantitative data in biological networks doc

... schematicallydepicted and the binding epitope for the anti-EpoR immunoglobulin isindicated. The calibrator, GST-EpoR, consists of the protein domaincontaining the antibody-binding site fused to ... erythropoietin receptor (EpoR)-inducedactivation of ERK1 in the hematopoietic suspensioncell line, BaF3-hemaglutinin-tagged (HA)-EpoR, and the interleukin-6 (IL-6)-induced activation of the signaltransducer ... spline approximations, as indi-cated by solid lines. Randomization reduced the standard deviation of the smoothing splines by a factor of 14.M. Schilling et al. Strategies for standardizing...

Tài liệu Báo cáo khoa học: cN-crystallin and the evolution of the bc-crystallin superfamily in vertebrates pdf

... structures of c-crystallins are clearly related to those of b-crystallins and AIM1, with precisely conserved intron positionsdelineating protein domains; however, in the c-crystal-lins the introns ... only 44% and, relat-ive to cS, the protein has insertions (mainly of gly-cines), in the c–d loops of motifs I and III and in theconnection between motifs III and IV (Fig. 1). Thisprotein was ... anormal crystallin and may instead have a separatefunction.The expression of cN in the retina is particularlyinteresting. There is evidence for expression of cSinthe retina and cornea, but...

Tài liệu Báo cáo khoa học: Cobalamin uptake and reactivation occurs through speciﬁc protein interactions in the methionine synthase–methionine synthase reductase complex docx

... fromS-adenosylmethionine, regenerates the active form of hMS. During reactivation of hMS, the FMN domain of MSR (light grey) and the C-ter-minal activation of hMS (grid-barrel) interact with the cobalamin-binding ... theS-adenosylmethionine-binding site (see Fig. S3 and Doc. S1). Thus, the propensity of hydrophobic resi-dues on the putative binding interface of the MSRFMN domain suggests less emphasis on electrostaticinteractions ... domainwith the hMS AD.Fig. S2. Comparison of the electrostatic potentials of the surface of the CPR FMN domain and of a model of the FMN domain of human MSR.Fig. S3. Electrostatic potentials of...

Tài liệu Báo cáo khoa học: Helix mobility and recognition function of the rat thyroid transcription factor 1 homeodomain – hints from 15N-NMR relaxation studies pdf

... dis-tribution of the energy between the overall tumbling and the internal mobility, and is indicative of thedegree of internal restraint of each15N–1H vectormotion. In Fig. 4, most of the points ... Universita`di Udine, ItalyHomeodomains (HDs) comprise a very well-knownclass of DNA-binding domains occurring in a largefamily of transcription activators involved in thedetermination of cell development ... suggesting the occurrence of eithera kinking or tightening of the local geometry. Asimilar discontinuity had been noted in solution also in the Antp HD [8,9] and the Antp (C39S) HD [10], and indeed,...

Tài liệu Báo cáo khoa học: Puriﬁcation and structural characterization of a D-amino acid-containing conopeptide, conomarphin, from Conus marmoreus docx

... superimposedstructures of conomarphin (red) and L-Phe13-conomarphin (gray). The side chain of L-Phe13 might cause spatial hindrance tothe side chain of Lys9 and Hyp10 in formingthe tight loop as in conomarphin. ... sidechain of Lys9, Hyp10 and D-Phe13 of cono-marphin is shown in stick mode, and theside chain of L-Phe13 in L-Phe13-conomar-phin is shown as a gray stick.Y. Han et al. AD-amino acid-containing ... Academy of Sciences, China3 Department of Chemistry, Renmin University of China, Beijing, China4 Research Institute of Pharmaceutical Chemistry, Beijing, ChinaConus snails are a group of predatory...

Tài liệu Báo cáo khoa học: The antibacterial and antifungal properties of trappin-2 (pre-elaﬁn) do not depend on its protease inhibitory function pptx

... activity of trappin-2 is independent of its intrinsic inhibitory activity and that trappin-2 and itsuninhibitory mutant are bactericidal because fewersurviving CFU were present after 3 h of incubation ... (µM)% of surviving CFUTrappin-2Trappin-2 + heparinTrappin-2 + NaCl C. albicans4050607080901000 5 10 15 20 25 30 35% of surviving CFUTrappin-2Trappin-2 + heparinTrappin-2 + NaCl ... blot analysis of elaﬁn and trappin-2 fractionatedon heparin-Sepharose. The heparin-binding capacities of elaﬁn and trappin-2 were evaluated by afﬁnity chromatography using heparin-Sepharose....

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