... is capable of reducing the level of fructose 2,6-P 2 inde- pendent of the phosphorylation state of iPFK-2. Reducing the level of fructose 2,6-P 2 and thus the activity of PFK-1 improves the supply of glucose 6-phosphate ... significance of the Warburg effect. We conclude that, besides the expression level of the meta- bolic enzymes involved in the gluco...
Ngày tải lên: 14/03/2014, 23:20
... show the critical role of the last amino acids in the C-terminus of MaL. Deletion of the four last amino acids strongly reduced the expression of the protein in T. reesei and S. cerevisiae. Further- more, ... preventing binding of oxygen. We analyzed the azide inhibition and determined the inhibition constants for sodium azide, in order to see the e...
Ngày tải lên: 16/03/2014, 00:20
Báo cáo khoa học: CpG methylation of the CENP-B box reduces human CENP-B binding pptx
... atom of guanine 16 by the CpG methylation may be a reason for the reduced specificity of CENP-B to the CENP-B box sequence. What is the functional meaning of the CpG methyla- tion of the CENP-B box ... methylation of the CENP-B box sequence reduces the binding affinity between CENP-B and the CENP-B box DNA nearly to the level of no...
Ngày tải lên: 16/03/2014, 18:20
Báo cáo khoa học: Mutational analysis of the C-domain in nonribosomal peptide synthesis pot
... identify their target in the C-domain using peptide mapping. T hus the inhibitory effect may be due to interference with other reactive residues in NRPS modules like the thiol g roup of the 4 Â-phosphopantethein-moiety ... bound in the binding poc ket o f a nother e nzyme molecule within the active homomultimer. This could explain the distance in sequence homology...
Ngày tải lên: 17/03/2014, 11:20
Báo cáo khoa học: New members of the brachyurins family in lobster include a trypsin-like enzyme with amino acid substitutions in the substrate-binding pocket potx
... 237 amino acids 15 amino acids ⁄ 14 amino acids 25 kDa ⁄ 4.07 PaTry2 GU338028 870 798 nucleotides 58 nucleotides AATAAA ⁄ 10 nucleotides 266 amino acids ⁄ 237 amino acids 15 amino acids ⁄ 14 amino ... nucleotides ATTAAA ⁄ 13 nucleotides 278 amino acids ⁄ 249 amino acids 15 amino acids ⁄ 14 amino acids 27 kDa ⁄ 4.6 New members of the brachyurins family in l...
Ngày tải lên: 23/03/2014, 03:20
Báo cáo khoa học: Quantitative assessment of the glyoxalase pathway in Leishmania infantum as a therapeutic target by modelling and computer simulation pot
... FEBS Quantitative assessment of the glyoxalase pathway in Leishmania infantum as a therapeutic target by modelling and computer simulation Marta Sousa Silva 1 , Anto ´ nio E. N. Ferreira 1 , Ana ... evaluating the relevance of the glyoxalase pathway as a potential therapeutic target by revealing the importance of critical parameters...
Ngày tải lên: 23/03/2014, 13:20
Báo cáo khoa học: Functional role of the linker region in purified human P-glycoprotein pot
... This kinetic analysis provided new insight into the role of the linker region. In addition, we fur- ther analyzed the functional role of the linker region based on the crystal structures of a ... cleavage of the linker [22]. Although these results provided valuable suggestions for the role of the P-gp linker region, the molecular details, such...
Ngày tải lên: 29/03/2014, 23:20
Báo cáo khoa học: " Immunohistochemical Study of the Endocrine Cells in the Pancreas of the Carp, Cyprinus carpio (Cyprinidae)" docx
... polypeptide Immunohistochemical Study of the Endocrine Cells in the Pancreas of the Carp, Cyprinus carpio (Cyprinidae) 309 Fig. 4. Somatostatin-IR cells in the pancreas of the carp. Note that these cells ... hormones secreted by endocrine cells in the pancreas are well recognized by Immunohistochemical Study of the Endocrine Cell...
Ngày tải lên: 07/08/2014, 15:20
Báo cáo khoa học: "CT myelography of the thoraco-lumbar spine in 8 dogs with degenerative myelopathy" pptx
Ngày tải lên: 07/08/2014, 18:21
Báo cáo khoa học: "Ultrasonographic examination of the carpal canal in dogs" doc
... Ultrasonography of the carpal canal in dogs 79 Fig. 2. Transverse ultrasonographic scans of the carpal canal at the proximal (P) and the distal (D) levels of the carpal canal. Color Doppler imaging is ... represent the collagen fibers within the tendon [10,11]. Our findings were in line with the preceding reports for the flexor tendons within the c...
Ngày tải lên: 07/08/2014, 23:22
Báo cáo khoa học: "Histological investigation of the multiplication step in secondary somatic embryogenesis of Quercus robur L" pptx
... pathways. 3.2.1. Indirect secondary embryogenesis The initial evidence of indirect secondary embryogenesis consisted in cell divisions occurring within the cortical tissue (figure 2-1) that provoked the swelling ... potentials for germination and further growth [30, 47]. In order to optimize the multiplication step in one Q. robur embryogenic line, we investigate...
Ngày tải lên: 08/08/2014, 14:20
Báo cáo khoa học: "Osteogenic sarcoma of the breast arising in a cystosarcoma phyllodes: a case report and review of the literature" pdf
... Access Osteogenic sarcoma of the breast arising in a cystosarcoma phyllodes: a case report and review of the literature Vinay Singhal 1* , Chintamani 2 and John M Cosgrove 1 Abstract Introduction: Primary ... from carcinosarcomas and metaplastic carcinomas as the management of the two differ. Introduction Carcinoma is the most common malignancy of...
Ngày tải lên: 10/08/2014, 23:21
Báo cáo y học: " Brown tumor of the maxillary sinus in a patient with primary hyperparathyroidism: a case report" ppsx
... rare case of brown tumor of the maxillary sinus due to primary hyperparathyroidism. Primary hyperparathyroidism is caused by a solitary adenoma in 80% of cases and by glandular hyperplasia in 20%. Conclusions: ... man- ifestations of hyperparathyroidism are brown tumors that appear in approximately 10% of cases and in advanced stages of the disease. T...
Ngày tải lên: 11/08/2014, 14:20
Báo cáo khoa học: "Molecular characterisation of the early response in pigs to experimental infection with Actinobacillus pleuropneumoniae using cDNA microarrays" doc
... Access Research Molecular characterisation of the early response in pigs to experimental infection with Actinobacillus pleuropneumoniae using cDNA microarrays Jakob Hedegaard 1 , Kerstin Skovgaard 2 , Shila Mortensen 2 , ... Determination of their specific roles during infection may lead to a better understanding of innate immunity in pigs. Competing...
Ngày tải lên: 12/08/2014, 18:21
Báo cáo khoa học: "Heterotopic ossification of the knee joint in intensive care unit patients: early diagnosis with magnetic resonance imaging" docx
... examine the potential therapeutic and quality of life benefit associated with an early diagnosis of HO. Conclusion The early MRI findings of HO in the knee joint are interstitial edema of the ... 8.2 Heterotopic ossification (HO) in the knee joint of 11 intensive care unit patients. Increase of serum levels of alkaline phosphatase (ALP) was...
Ngày tải lên: 13/08/2014, 03:20