Báo cáo khoa học: "CT myelography of the thoraco-lumbar spine in 8 dogs with degenerative myelopathy" pptx

Báo cáo khoa học: Enzymatic features of the glucose metabolism in tumor cells ppt

... iscapable of reducing the level of fructose 2,6-P2inde-pendent of the phosphorylation state of iPFK-2.Reducing the level of fructose 2,6-P2and thus the activity of PFK-1 improves the supply of glucose 6-phosphate ... signiﬁcance of the Warburg effect. We conclude that, besides the expression level of the meta-bolic enzymes involved in the glucose metabolism of tumor cells, the unique tumor- speciﬁc pattern of isozymes ... [115] reported the ﬁnding of two potential binding sites for HIF-1 in the ﬁrst intron of the PK-M gene. On the other hand, Yamada andNoguchi [116] reported that there is no HIF-1 bindingsequence...

Báo cáo khoa học: Essential role of the C-terminus in Melanocarpus albomyces laccase for enzyme production, catalytic properties and structure pdf

... show the critical role of the lastamino acids in the C-terminus of MaL. Deletion of the four last amino acids strongly reduced the expression of the protein in T. reesei and S. cerevisiae. Further-more, ... preventing binding of oxygen.We analyzed the azide inhibition and determined the inhibition constants for sodium azide, in order to see the effect of the mutation (L559A) on the binding properties ... between the C-terminus and His140 isbroken, and the stability of the trinuclear site isdecreased, the binding of azide to the trinuclear sitemay be decreased. The depletion of the T2 copper and chloride...

Báo cáo khoa học: CpG methylation of the CENP-B box reduces human CENP-B binding pptx

... atom of guanine 16 by the CpG methylation may be a reason for the reduced speciﬁcity of CENP-B to the CENP-B box sequence.What is the functional meaning of the CpG methyla-tion of the CENP-B box ... methylation of the CENP-B box sequence reduces the binding afﬁnitybetween CENP-B and the CENP-B box DNA nearlyto the level of nonspeciﬁc binding. In the CENP-B( 1–129)–methylated DNA complex model, the ... Therefore, the CpG methylation at sites 1 and 3 of the CENP-B box DNA reduces the CENP-B binding afﬁnity almost to the level of nonspeciﬁc DNA binding. DiscussionIn this study, we found that CpG methylation...

Báo cáo khoa học: Mutational analysis of the C-domain in nonribosomal peptide synthesis pot

... identify their target in the C-domain using peptide mapping. T hus the inhibitory effect may be due tointerference with other reactive residues in NRPS moduleslike the thiol g roup of the 4 Â-phosphopantethein-moiety ... bound in the binding poc ket o f a nother e nzymemolecule within the active homomultimer. This could explain the distance in sequence homology with NRPSs C-domains displayed in the alignment of the ... Nevertheless, the datapresented in this s tudy excludes the idea of a c atalytictriad involved in C-domain catalysis of NRPSs. With the đnding of the additional residue R62 and conđrming the residues...

Báo cáo khoa học: New members of the brachyurins family in lobster include a trypsin-like enzyme with amino acid substitutions in the substrate-binding pocket potx

... 237 amino acids 15 amino acids ⁄ 14 amino acids 25 kDa ⁄ 4.07PaTry2 GU338028 870 798 nucleotides 58 nucleotides AATAAA ⁄ 10 nucleotides 266 amino acids ⁄ 237 amino acids 15 amino acids ⁄ 14 amino ... nucleotides ATTAAA ⁄ 13 nucleotides 278 amino acids ⁄ 249 amino acids 15 amino acids ⁄ 14 amino acids 27 kDa ⁄ 4.6 New members of the brachyurins family in lobster E. Perera et al.3498 FEBS Journal 277 ... AATAAA ⁄ 13 nucleotides 266 amino acids ⁄ 237 amino acids 15 amino acids ⁄ 14 amino acids 25 kDa ⁄ 4.07PaTry1b GU338027 873 798 nucleotides 61 nucleotides AATAAA ⁄ 13 nucleotides 266 amino acids...

Báo cáo khoa học: Quantitative assessment of the glyoxalase pathway in Leishmania infantum as a therapeutic target by modelling and computer simulation pot

... FEBS Quantitative assessment of the glyoxalase pathway in Leishmania infantum as a therapeutic target by modelling and computer simulation Marta Sousa Silva1, Anto´nio E. N. Ferreira1, Ana ... evaluating the relevance of the glyoxalase pathway as a potential therapeutic target by revealing the importance of critical parameters of this pathway in Leishma-nia infantum. A sensitivity analysis ... play only a minor role in maintaining a low intracellularmethylglyoxal concentration. The importance of the glyoxalase pathway as a therapeutic target is very small, compared to the much greater...

Báo cáo khoa học: Functional role of the linker region in puriﬁed human P-glycoprotein pot

... This kinetic analysis provided new insightinto the role of the linker region. In addition, we fur-ther analyzed the functional role of the linker region based on the crystal structures of a ... cleavage of the linker [22]. Althoughthese results provided valuable suggestions for the role of the P-gp linker region, the molecular details, suchas the involvement of the linker region in substraterecognition, ... subunit B is shown in purple. The putative linker region of P-gp is shown as adotted line and the start of the linker region is denoted with an asterisk. The minimumpath of the linker region is shown...

Báo cáo khoa học: " Immunohistochemical Study of the Endocrine Cells in the Pancreas of the Carp, Cyprinus carpio (Cyprinidae)" docx

... polypeptide Immunohistochemical Study of the Endocrine Cells in the Pancreas of the Carp, Cyprinus carpio (Cyprinidae) 309Fig. 4.Somatostatin-IR cells in the pancreas of the carp. Note that these cells ... hormones secretedby endocrine cells in the pancreas are well recognized by Immunohistochemical Study of the Endocrine Cells in the Pancreas of the Carp, Cyprinus carpio (Cyprinidae)Hee-Sun Kong, ... Immunohistochemical Study of the Endocrine Cells in the Pancreas of the Carp, Cyprinus carpio (Cyprinidae) 311addition, some cells were also demonstrated in the mantleand central regions in...

Báo cáo khoa học: "CT myelography of the thoraco-lumbar spine in 8 dogs with degenerative myelopathy" pptx

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Báo cáo khoa học: "Ultrasonographic examination of the carpal canal in dogs" doc

... Ultrasonography of the carpal canal in dogs 79Fig. 2. Transverse ultrasonographic scans of the carpal canal at the proximal (P) and the distal (D) levels of the carpal canal. Color Doppler imaging is ... represent the collagen fibers within the tendon [10,11]. Our findings were in line with the preceding reports for the flexor tendons within the carpal canal. Ultrasonographic identification of the ... proximal to the side of the carpal pad. The hair of the posterior side of the left carpus was clipped and the transverse ultrasonographic scans were obtained following neutral positioning of the...

Báo cáo khoa học: "Histological investigation of the multiplication step in secondary somatic embryogenesis of Quercus robur L" pptx

... pathways.3.2.1. Indirect secondary embryogenesis The initial evidence of indirect secondary embryogenesis consisted in cell divisions occurringwithin the cortical tissue (figure 2-1) that provoked the swelling ... potentials forgermination and further growth [30, 47]. In order to optimize the multiplication step in oneQ. robur embryogenic line, we investigated the process of secondary embryogenesis from ... tothose obtained without growth regulators, showinghigh frequency of direct secondary embryogenesis. In the presence of IBA/BAP, the indirect secondary embryogenesis became the prevailing pathway,...

Báo cáo khoa học: "Osteogenic sarcoma of the breast arising in a cystosarcoma phyllodes: a case report and review of the literature" pdf

... AccessOsteogenic sarcoma of the breast arising in a cystosarcoma phyllodes: a case report and review of the literatureVinay Singhal1*, Chintamani2 and John M Cosgrove1AbstractIntroduction: Primary ... fromcarcinosarcomas and metaplastic carcinomas as the management of the two differ.IntroductionCarcinoma is the most common malignancy of the breast. Sarcomas form a minority of breast neoplasms.Extra-skeletal ... tumors of the breast containing bone and cartilage are extremely rare, and an osteogenic sarcoma arising from a cystosarcoma phyllodes is exceptional. Case presentation: A 40-year-old Indian woman...

Báo cáo y học: " Brown tumor of the maxillary sinus in a patient with primary hyperparathyroidism: a case report" ppsx

... rare case of brown tumor of the maxillary sinus due to primary hyperparathyroidism. Primary hyperparathyroidism is caused by a solitary adenoma in 80% of cases and by glandular hyperplasia in 20%.Conclusions: ... man-ifestations of hyperparathyroidism are brown tumors thatappear in approximately 10% of cases and in advancedstages of the disease. These may appear in any part of the skeleton, most commonly seen ... [1].Hyperparathyroidism is frequently caused by the develop-ment of a parathyroid adenoma and less often byhyperplasia or a carcinoma. Some parathyroid adenomasand hyperplasias are familial...

Báo cáo khoa học: "Molecular characterisation of the early response in pigs to experimental infection with Actinobacillus pleuropneumoniae using cDNA microarrays" doc

... AccessResearchMolecular characterisation of the early response in pigs to experimental infection with Actinobacillus pleuropneumoniae using cDNA microarraysJakob Hedegaard1, Kerstin Skovgaard2, Shila Mortensen2, ... Determination of their specific roles during infection may lead to a better understanding of innateimmunity in pigs. Competing interests The author(s) declare that they have no competing inter-ests.Authors' ... serofibrinous pleuritis [1]. Infection of the porcine lung with A. pleuropneumoniae has previouslybeen reported to result in a local production of proinflam-matory proteins or mRNA encoding the...

Báo cáo khoa học: "Heterotopic ossification of the knee joint in intensive care unit patients: early diagnosis with magnetic resonance imaging" docx

... examine the potential therapeutic and quality of life benefit associated with an early diagnosis of HO.Conclusion The early MRI findings of HO in the knee joint are interstitialedema of the ... 8.2Heterotopic ossification (HO) in the knee joint of 11 intensive care unit patients. Increase of serum levels of alkaline phosphatase (ALP) was the earliest indication of HO. MRI, magnetic resonance ... resonance imaging (MRI) findings onclinical suspicion of HO in the knee joint of patients hospitalised in the intensive care unit (ICU).Methods This was a case series of 11 patients requiringprolonged...

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