Báo cáo khoa học: " Pharmacokinetics and dosage regimen of ceftriaxone in E coli lipopolysaccharide induced fever in buffalo calves" pot

... available about the influence of fever on the pharmacokinetics of cephalosporins. [1,5,16,19]. Since there is no information available on the pharmacokinetics and dosage regimen of ceftriaxone in febrile ... objective of the present study was to determine a satisfactory dosage regimen in febrile buffalo calves. It is not axiomatic to compute the dosage regim...

Ngày tải lên: 07/08/2014, 18:21

... on chromosome 2R. Only two nucleotide differences, which do not affect the deduced amino acid sequence, exist between the sequences of DmEH and jheh2, indicating that these two are the same gene. Three ... possible EH-encoding genes, designated jheh1, jheh2,andjheh3 are located between 55F7 and 55F8 on chromosome 2R. The deduced amino acid sequences of all three genes were compared wi...

Ngày tải lên: 07/03/2014, 21:20

... binding sites and their related potency to stimulate adenylate cyclase and phospholipase C in CHO cells expressing the human NK-1 receptor. All experiments have been performed in triplicate in ... increase peptide stability at the expense of a minimal decrease in its activity. HGly (named by the authors b-alanine) has been previously introduced in the sequence of the C-termi...

Ngày tải lên: 08/03/2014, 08:20

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Ngày tải lên: 07/08/2014, 18:21

... anionicity of their nonbridging oxygens. Sulfonamide-linked nucleosides were employed first in antisense technology, where they were found to be highly soluble, and resistant to both enzyme-catalyzed and ... http://wileyonlinelibrary.com/ onlineopen#OnlineOpen_Terms (Received 17 September 2010, revised 29 November 2010, accepted 1 December 2010) doi:10.1111/j.1742-4658.2010.07976.x Mol...

Ngày tải lên: 14/02/2014, 22:20

... site, even though only the amino acid residues involved in the binding of the purine base were identified, while the ribose moiety was completely disordered [11]. Mutation of two residues involved in ... Variation of the protein molecular mass in the presence of specific effectors as estimated by the ratio of the scattered light intensity. Values are means ± SD of at least thr...

Ngày tải lên: 15/02/2014, 01:20

... present in the human genome. A recent study identified this homologue as a gene potentially involved in the development of ovarian cancer. In a genome-wide screening for differently methylated ... poorly characterized. Sequence analysis of a wide range of species indicates that HPRT have eleven completely conserved amino acids, whereas PRTFDC1 genes do not show full conservation o...

Ngày tải lên: 15/02/2014, 01:20

... better per- formance of the enzyme, a binding pocket of appropri- ate size is necessary. We then replaced the three residues with a range of amino acids using site-directed saturated mutagenesis, ... analysis were performed using T-COFFEE [44]. Docking simulation of substrate on the active site of HYD Js The substrate binding pockets of HYD Js and the mode of interaction betwe...

Ngày tải lên: 18/02/2014, 08:20

... N et al. (2004) Role of the C-terminal tyrosine of ferredoxin–nicotinamide adenine dinucleo- tide phosphate reductase in the electron transfer processes with its protein partners ferredoxin and flavodoxin. ... the element is inferred from deletion mutants, therefore the effects reported in the table are the opposite of the observed effects. d All but one report indicate decreased c...

Ngày tải lên: 18/02/2014, 11:20

... the H transfer have been shown to exhibit a significant pres- sure-dependence of both rate and KIE [57]. Thus, in principle, the pressure-dependence of an isotope effect provides an excellent method ... plots. We have also plotted (C) the com- bined pressure and temperature dependence of the observed KIE on hydride transfer during the reductive half reaction of morphinone reducta...

Ngày tải lên: 18/02/2014, 11:20