... protein, the bindingenthalpy of intact apoE4 was consistent with the sum of the enthalpies for the 22 kDa and 10 kDa derivatives, indica-ting that both NH2- and COOH-terminal domains bind to the ... relationships of the apoEisoforms, including their stability [21], self-association in the presence and absence of phospholipid [4], and their ability to bind preferentially to different lipoprotein classes ... forEggPtdCho /TO fraction 6 in the presence of both apoEisoforms. However, a greater increase in the ordinatemaximum and area under the curve is obvious in the presence of the apoE4 isoform (Fig....