Báo cáo khoa học: " Functional Role of Serine Residues of Transmembrane Dopamin VII in Signal Transduction of CB2 Cannabinoid Receptor" doc

... classical cannabinoid and aminoalkylindole derivative is different. In addition, amino Functional Role of Serine Residues of Transmembrane Dopamin VII in Signal Transduction of CB2 Cannabinoid Receptor Man-Hee ... a cannabinoid receptor and functional expression of the Functional Role of Serine Residues of Transmembrane Dopamin VII in...

Ngày tải lên: 07/08/2014, 15:20

... Fumarate-binding site for human m-NAD-ME. (A) Homotetramer of human m-NAD-ME (Proein Data Bank code: 1PJ3). (B) Fumarate- binding site of m-NAD-ME. The corresponding amino acids in the fumarate-binding ... of human m-NAD-ME in complex with fumarate has been determined, the binding network of fumarate in the enzyme has become clear. In the fumarate-binding pocket, two arginyl...

Ngày tải lên: 23/03/2014, 06:20

... region’ of $ 75 amino acids that connects two homologous halves, each of which contain a transmembrane domain followed by a nucleotide-binding domain. To investigate the role of the linker region, ... effects of interacting proteins but can also be used to perform kinetic analy- ses of the native and linker-cleaved P-gp. In the present study, we investigated the functional...

Ngày tải lên: 29/03/2014, 23:20

... the bC-domain in a ‘knob’–‘hole’ type of interaction [7,9]. The remain- ing part of site ‘C’ (Bb19–46) probably remains bound to the fibrin D-domain. To determine the localization of a complementary ... polymerization sites of fibrin monomers. Site ‘A’ (Aa17–19) is exposed in the N-terminal region of the Aa-chain by the splitting off of fibrinopeptide A [6]. Site ‘a’ is formed by...

Ngày tải lên: 30/03/2014, 03:20

... system, resulting in encouraging early local con- trol rates (92%) and minimal toxicity. The delivery of hundreds of beams while continuously tracking respira- tory tumor movement and adjusting beam ... of the patients in the current trial discontinued smoking in the distant past (>3 years prior to treatment) or had never smoked. The mean percentage of the total lung volume r...

Ngày tải lên: 09/08/2014, 10:21

... day of training, to measure the improve- ment in spatial learning. Thigmotaxis, circling and floating activities, as defined by the hsv image software, were recorded and animals (n = 4) displaying ... mutations) expresses elevated levels of Ab protofibrils in the brain, making tg-ArcSwe a highly suitable model for investigating the pathogenic role of these Ab assemblies. In the pre...

Ngày tải lên: 23/03/2014, 06:20

... resections. Response to CRT Comparison of stage of disease before and after treatment in 31 operated CRT patients demonstrated down-staging in 58%, no change in 23% and up-staging in 19% of the patients (Figure ... planning study evaluating the potential of dose escalation in conformal radiotherapy of the oesophagus. Radiother Oncol 2000, 57:183-193. 13. Sobin LH, Witteki...

Ngày tải lên: 09/08/2014, 03:21

... each of grade 3 vomiting and of febrile neutropenia requiring admission. In 6 of 30 patients, carboplatin was substituted for cisplatin owing to renal impairment. At the end of radiotherapy, in ... to patients encountered in routine clinical practice. The results of institutional series of patients treated outside clinical trials are invaluable in exploring these issues. T...

Ngày tải lên: 09/08/2014, 09:20

... that the N-terminal domain is involved in protein–protein interactions with other hydrophilic domains of neighboring integral membrane subunits, and interspecies interactions are incompatible. From ... proteins reveals a high degree of conservation in the C-terminal domain (including the transmembrane region), but a significant number of differ- ences in the N-terminal domain (lo...

Ngày tải lên: 19/02/2014, 16:20

... species. The role of Ydc2 for maintaining the content of mtDNA in fission yeast is not clear. Apart from DNA repair, recombination could be involved in the initiation of mtDNA replication (recombination-dependent ... recombination in mtDNA inheritance in S. cerevisiae showed that budding cells were enriched in linear monomers of mtDNA. It was proposed that in addition to...

Ngày tải lên: 20/02/2014, 11:20