Báo cáo khoa học: " Functional Role of Serine Residues of Transmembrane Dopamin VII in Signal Transduction of CB2 Cannabinoid Receptor" doc

... classical cannabinoid andaminoalkylindole derivative is different. In addition, amino Functional Role of Serine Residues of Transmembrane Dopamin VII in Signal Transduction of CB2 Cannabinoid ReceptorMan-Hee ... a cannabinoid receptor and functional expression of the Functional Role of Serine Residues of Transmembrane Dopamin VII in Signal Transduction of CB2 Cannabinoid Receptor191651∼658.26. Chin, C.N., Luca-Lenard, ... the binding sitewith HU-210 and CP55940. In addition, serine 292mighttakemoreimportantroleinCB2receptorandG-protein signaling than serine 285.Key Words : Cannabinoids, CB2, Serine, G protein,...

Báo cáo khoa học: Functional role of fumarate site Glu59 involved in allosteric regulation and subunit–subunit interaction of human mitochondrial NAD(P)+-dependent malic enzyme pptx

... Fumarate-binding site for human m-NAD-ME. (A) Homotetramer of human m-NAD-ME (Proein Data Bank code: 1PJ3). (B) Fumarate-binding site of m-NAD-ME. The corresponding amino acids in the fumarate-binding ... of human m-NAD-ME in complex with fumarate hasbeen determined, the binding network of fumarate in the enzyme has become clear. In the fumarate-bindingpocket, two arginyl residues, Arg67 and ... low enzyme activity in the absence of fuma-rate. This may result from shortening the length of theside chain in the enzyme, causing geometrical changes in the fumarate-binding pocket, which may...

Báo cáo khoa học: Functional role of the linker region in puriﬁed human P-glycoprotein pot

... region’ of $ 75 amino acids that connects two homologous halves, each of whichcontain a transmembrane domain followed by a nucleotide-bindingdomain. To investigate the role of the linker region, ... effects of interactingproteins but can also be used to perform kinetic analy-ses of the native and linker-cleaved P-gp. In the present study, we investigated the functional role of the linker ... symbol. The initial hydrolysis ratewas routinely calculated using a one-point assay at 30 minbecause linearity in the time course was conﬁrmed until30 min within 37 lm per min of the initial rate...

Báo cáo khoa học: Functional role of Bb-chain N-terminal fragment in the ﬁbrin polymerization process pdf

... the bC-domain in a ‘knob’–‘hole’ type of interaction [7,9]. The remain-ing part of site ‘C’ (Bb19–46) probably remains boundto the ﬁbrin D-domain. To determine the localization of a complementary ... polymerization sites of ﬁbrin monomers.Site ‘A’ (Aa17–19) is exposed in the N-terminal region of the Aa-chain by the splitting off of ﬁbrinopeptide A[6]. Site ‘a’ is formed by amino acid residues cGln329,cAsp330, ... E-domain of the ﬁbrinmolecule, the complementary site ‘c’ is suggested to besituated in the D-domain. We have tried to model theintermolecular binding between the D-domain of one ﬁbrin desAA...

Báo cáo khoa học: " Radical stereotactic radiosurgery with real-time tumor motion tracking in the treatment of small peripheral lung tumors" docx

... system, resulting in encouraging early local con-trol rates (92%) and minimal toxicity. The delivery of hundreds of beams while continuously tracking respira-tory tumor movement and adjusting beam ... of the patients in the current trialdiscontinued smoking in the distant past (>3 years priorto treatment) or had never smoked. The mean percentage of the total lung volume receiving a minimum ... lasting several weeks, developed in 7 of 11patients with lesions within 5 mm of the pleura.Grade III pneumonitis was observed in 2 patients (8%).One of the patients received concurrent Gefitinib...

Báo cáo khoa học: Amyloid-b protoﬁbril levels correlate with spatial learning in Arctic Alzheimer’s disease transgenic mice docx

... day of training, to measure the improve-ment in spatial learning. Thigmotaxis, circling and ﬂoatingactivities, as deﬁned by the hsv image software, wererecorded and animals (n = 4) displaying ... mutations) expresses elevated levels of Ab protoﬁbrils in the brain, making tg-ArcSwe a highly suitable modelfor investigating the pathogenic role of these Ab assemblies. In the presentstudy, we estimated ... h. Interestingly, highlevels of protoﬁbrils, but not total Ab, were associatedwith inferior spatial learning, at least in young mice.This implies that Ab protoﬁbril levels in the brain of tg-ArcSwe...

Báo cáo khoa học: "High-dose chemoradiotherapy followed by surgery versus surgery alone in esophageal cancer: a retrospective cohort study" doc

... resections.Response to CRTComparison of stage of disease before and after treatment in 31 operated CRT patients demonstrated down-staging in 58%, no change in 23% and up-staging in 19% of thepatients (Figure ... planning study evaluating the potential of dose escalation in conformal radiotherapy of the oesophagus. Radiother Oncol 2000, 57:183-193.13. Sobin LH, Wittekind C, International Union Against ... the axial planning CT images using outlines of the defined primary tumor and nodal disease obtainedfrom the EUS and CT scans. The delineated GTV was themacroscopic tumor including possible macroscopic...

Báo cáo khoa học: "A single centre experience with sequential and concomitant chemoradiotherapy in locally advanced stage IV tonsillar cancer" doc

... each of grade 3 vomitingand of febrile neutropenia requiring admission. In 6 of 30patients, carboplatin was substituted for cisplatin owingto renal impairment. At the end of radiotherapy, in ... topatients encountered in routine clinical practice. Theresults of institutional series of patients treated outsideclinical trials are invaluable in exploring these issues.The series of 41 patients ... compromising tumour control. The future of improving the outcomes of head and neck therapy, in terms of both tumour control and toxicity, may lie in ourability to individualise treatment. This will involve...

Tài liệu Báo cáo khoa học: The role of the ESSS protein in the assembly of a functional and stable mammalian mitochondrial complex I (NADH-ubiquinone oxidoreductase) pptx

... that the N-terminal domain is involved in protein–protein interactions with other hydrophilic domains of neighboring integral membrane subunits, and interspeciesinteractions are incompatible.From ... proteins reveals a high degree of conservation in the C-terminal domain (including the transmembrane region), but a signiﬁcant number of differ-ences in the N-terminal domain (located on the matrix ... thebovine complex a large subdomain is made up of  20integral membrane proteins contributing > 60 transmem-brane segments. Some of these must be intimately involved in proton pumping. Another...

Tài liệu Báo cáo khoa học: Functional dissection of the Schizosaccharomyces pombe Holliday junction resolvase Ydc2: in vivo role in mitochondrial DNA maintenance pptx

... species.The role of Ydc2 for maintaining the content of mtDNA in ﬁssion yeast is not clear. Apart from DNA repair,recombination could be involved in the initiation of mtDNA replication (recombination-dependent ... recombination in mtDNA inheritance in S. cerevisiae showed that buddingcells were enriched in linear monomers of mtDNA. It wasproposed that in addition to a role in initiating a rolling-circle DNA ... recombination could be instrumen-tal in resolving concatamers into linear monomers in theprocess of mtDNA partitioning and transmission into buds[11].Several groups identiﬁed the Ydc2 protein of...

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