Báo cáo khoa học: "SR144528 as Inverse Agonist of CB2 Cannabinoid Receptor" docx

... CB2 and adenylyl cyclase type V (for adenylyl cyclase). The classical potent cannabinoid agonist, HU210, was used for the assays of binding affinity and adenylyl cyclase. The assays of binding affinity ... The SR144528 as Inverse Agonist of CB2 Cannabinoid Receptor Man-Hee Rhee and Sang-Keun Kim 1* Dept. of Cell Biology & Physiology, Washington Univ., School of Me...

Ngày tải lên: 07/08/2014, 15:20

... analysis of primary transcript levels, it appeared that the rate of transcription of the CB1 gene was decreased in the striata of R6 mice and that t his decrease led to the observed decre ase in ... used as controls in the RPA assays. b-actin levels are not affected by theexpressionofexon1ofmutantHD [18] and the amount of protected b-actin-specific probe was u sed t o normalize the...

Ngày tải lên: 16/03/2014, 18:20

... it has been shown that the DRP 5B is responsible for the fission of chlorop- lasts as well as of peroxisomes [31]. Additionally in A. thaliana it has been shown that three out of five PEX11 isoforms ... elongated clusters of peroxisomes were observed and the cyto- plasm of the cells was crowded with peroxisomes [22,23]. In contrast, deletion of PEX11 resulted in a strong decreas...

Ngày tải lên: 15/03/2014, 23:20

... that the occur- rence of terms representative of the assembly and disassembly of FDSs in the classical expression of the density of entropy production are character- istic of living systems. Abbreviation FDS, ... pH-dependent association ⁄ dissociation of the V1 and V0 domains of the yeast vacuolar H + - ATPases [48–50]; the promo- tion by substrate binding of the assembly...

Ngày tải lên: 19/02/2014, 06:20

... 1986; Ferreira and Henderson, 1986). As a baseline test case of the tagger, the well-established asymmetry between subject- and object-relative clauses was tested as shown in (11). (11) a. The editor ... man was very im- pressed (Trueswell, 1996) because accepted is bi- ased as a past participle. This result is compatible with the findings of Trueswell (1996). However, the bias towar...

Ngày tải lên: 20/02/2014, 11:21

... This assay was used to measure the activity of wild-type PrP. A concentration of 0.5 lgÆmL )1 PrP was found to inhibit 70% of the formazan production in the assay. This concentration was used ... activity of PrP. Production of deletion mutants of PrP On the basis of the results with antibodies, a series of PrP mutants were made to assess whether deletions of certain domains...

Ngày tải lên: 21/02/2014, 00:20

... representation of certain classification +.asks. A procedure has been outlined ~nereby a set of criteria for membership in a particular class may be transformed into an exemplary instance of a member of ... when a legal class must be assigned to the facts of the case at hand, but when an exact match cannot be roland between those facts and any of the definitions of poss...

Ngày tải lên: 21/02/2014, 20:20

... between the progress of fibril formation and an increase of the slow anisotropic component as a result of the probe binding to increas- ingly larger fibrillar structures. Recently, it was also demonstrated ... control the assembly and toxicity of amyloid oligomers. To clarify the mechanism of fibril formation and the relation of the amyloidogenesis processes to numerous amyloid dis...

Ngày tải lên: 06/03/2014, 09:22

... binding domain vector pAS2 to form pAS-SmRXR1(CF) and pAS-SmRXR2 pre- viously [7,9,10,55]. Yeast strain AH109 was transformed with 1 lg of the following plasmids: pAS-SmRXR1(CF), pAS-SmRXR2, pGBK-SmNR1(CF), ... luciferase was normalized by expression of Renilla luciferase. Fold activation of the reporter gene was calculated by dividing the normalized firefly luciferase value of each exp...

Ngày tải lên: 07/03/2014, 11:20

... explanation of the (apparent) Subiacency violation, is to assume that Italian and Spanish select C and NP as bounding nodes, a set different from that of English. The first phrase 'che ... if we assume that the type of the A -Chain attribute on chain nodes is a last-in/first, out (lifo) stack of integers, into which the integers identifying ,~-chain heads are pushed...

Ngày tải lên: 08/03/2014, 18:20