... be used in clinical immune ther- apy in order to induce immune responses in an anti- gen-specific manner in patients suffering from cancer or viral infections [20]. Cancer therapy is a principal ... the insights gained by better understanding embryonic hematopoiesis can meet clinical needs (in the fields of AIDS, immunotherapy, blood disorders and cancer treatment, for example)...
Ngày tải lên: 22/03/2014, 17:20
... shock proteins ClpP1, ClpC1, ClpX and ClpC2 have been annotated. Bearing in mind the importance of the Clp family of proteins in survival and virulence, it is of interest to understand the mode of action ... N-domain, homologous to the N-domains of ClpA or ClpB, and a linker domain homologous to, but half the size of, the linker domain of ClpB [19]. The N-terminal regio...
Ngày tải lên: 23/03/2014, 06:20
Tài liệu Báo cáo khoa học: Diol dehydratase-reactivating factor is a reactivase – evidence for multiple turnovers and subunit swapping with diol dehydratase pdf
... cobalamin at 0 min (thick solid line), 30 min (thin solid line), 60 min (thin long-dashed line), 120 min (thin short-dashed line), 240 min (thin dotted line) and 360 min (thick dotted line) of incubation, ... model of damaged cofactors) for free adeninylpentylcobalamin (AdePeCbl) (an inactive coenzyme analog containing the adenine ring in the upper axial ligand; a model of intact co...
Ngày tải lên: 15/02/2014, 01:20
Tài liệu Báo cáo khoa học: High affinity copper binding by stefin B (cystatin B) and its role in the inhibition of amyloid fibrillation docx
... obtained from injections of the metal into a solution of the protein. Typically an initial injection of 2 lL copper chelate solution was followed by a further 29 injections of 4 lL of Cu(II) into ... stage of tetramerization. Possibly, loss of copper binding could still allow domain swapping to occur. It is of interest that a N-terminally truncated pri- on protein, lacking the...
Ngày tải lên: 19/02/2014, 06:20
Tài liệu Báo cáo khoa học: Specific interaction between the classical swine fever virus NS5B protein and the viral genome pdf
... these minus-strand RNA fragments (Fig. 4 C). Therefore, t he 3¢ ÔCATATGCTCÕ sequence of 3¢ terminal of the minus-strand genome is essential to binding of the CSFV NS5B protein. The minus-strand 3¢ ... mechanism of initiation from the very 3 ¢ termina l of 3¢ UTR might be one of peculiarities of CSFV replication because the sequence of the 3¢ terminal of 3¢ UTR is necessary f...
Ngày tải lên: 19/02/2014, 16:20
Tài liệu Báo cáo khoa học: "Extracting Comparative Sentences from Korean Text Documents Using Comparative Lexical Patterns and Machine Learning Techniques" doc
... comparative- sentence candidate, we use continuous words sequence within the radius of 3 (the window size of 7) of each keyword in the sentence; we expe- rimented with radius options of 2, 3, and 4 and we ... adverb and comparative, and RBS: adverb and superlative 153 Our final goal is to find an effective method to extract S1 and S2, but single-keyword searching j...
Ngày tải lên: 20/02/2014, 09:20
Tài liệu Báo cáo khoa học: "A Composite Kernel to Extract Relations between Entities with both Flat and Structured Features" ppt
... about 110 minutes and 30 minutes to do training on the ACE 2003 (~77k training in- stances) and 2004 (~33k training instances) data, respectively. (2) Further Improvement: One of the potential ... be handled by allowing grammar-driven partial rule matching and other approximate matching mechanisms in the parse tree kernel calculation. Finally, it is worth noting that by int...
Ngày tải lên: 20/02/2014, 12:20
Tài liệu Báo cáo khoa học: The tungsten-containing formate dehydrogenase from Methylobacterium extorquens AM1: Purification and properties docx
... molybdopterin guanine dinucletoide cofactors of Fdh H of E. coli (MGD 801 and MGD 802 )that were found to be invariant among molybdopterin-containing FDH [34] are shown in red. Amino acids coordinating MGD801 ... molybdopterin binding family of FDHs. Fdh1A shares 40% of identical amino acid residues with the catalytic a subunits of the two tungsten and selenocysteine-contain...
Ngày tải lên: 20/02/2014, 23:20
Tài liệu Báo cáo khoa học: A synthetic weak neurotoxin binds with low affinity to Torpedo and chicken a7 nicotinic acetylcholine receptors docx
... 62–68 amino acids and belong to the structural family of Ôthree-fingeredÕ folded toxins, which includes the cardiotoxins, muscarinic toxins, acetylcholin- esterase inhibitors and the a-neurotoxins ... at equilibrium, the effect of toxins on the 125 I-labelled a-Bgtx binding. Varying amounts of toxins were incubated with 3 n M of active sites of receptors and 5 n M of 125 I-la...
Ngày tải lên: 21/02/2014, 03:20
Báo cáo khoa học: Amyloid oligomers: spectroscopic characterization of amyloidogenic protein states docx
... probes and optical spectroscopy are now entering a phase enabling the in vivo interrogation of the role of oligomers in amyloidosis. Such techniques used in parallel with in vitro experiments, of increasing ... composed of the SH3 domain of PI3 kinase [42,43]. By mixing these labelled proteins in a 50 : 50 ratio and following the aggregation process, their data reveale...
Ngày tải lên: 06/03/2014, 09:22