Báo cáo khoa học: "Activation domain in P67phox regulates the steady state reduction of FAD in gp91phox" pot

... determine the domain in p67phoxwhich is essential for regulating the steady state of FAD reduction. The minimal length of p67phox for for regulating the steady state of FAD reduction is shown ... 5695-7.Activation domain in p67phox regulates the steady state reduction of FAD in gp91phox29(Table 1). The steady state percent reduction of the FAD analog and heme was determined as above in the completesystem ... steady state reduction of 8-thioacetamido -FAD (Fig. 3). The activation domain is not involved in the interaction with Rac1 orp47phox [10]. Therefore, the truncation of the activationdomain...

Báo cáo khoa học: Neural retina leucine-zipper regulates the expression of Ppp2r5c, the regulatory subunit of protein phosphatase 2A, in photoreceptor development pdf

... HT22 cells, to further examine the binding of Nrl to the Ppp2r5c promoter in vivo. Nrlbinding to the Ppp2r5c and rhodopsin promoters wasexamined by quantitative real-time of ChIP sampleswith ... during photoreceptor developmentwhen compared with the patterns of binding of Nrl to the rhodopsin promoter (Fig. 4C,D). The mRNA tran-script levels of Ppp2r5c and rhodopsin in mouse retinacorresponded ... precipitate the Ppp2r5c and rhodopsinpromoters in the HT22 cell lines. To conﬁrm the asso-ciation of Nrl with the Ppp2r5c promoter in mouse ret-ina, we used postnatal day (P)10 mouse retina for the quantitative...

Báo cáo khoa học: "Passive immunization using purified IgYs against infectious bursal disease of chickens in Pakistan" potx

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Báo cáo khoa học: N-Glycosylation is important for the correct intracellular localization of HFE and its ability to decrease cell surface transferrin binding pptx

... loss of the ability to regulate transferrin binding (Fig. 7B).By contrast, cells transfected with either the single ordouble mutants were all capable of reducing transfer-rin binding. In each ... interactionswith b2 microglobulin (b2M) [4,5,8–11]. In the absence of b2M binding, the protein misfolds and is retained in the endosplasmic reticulum (ER) where it induces anunfolded protein ... cells. In HFE, the proximity of the two a helices and the presence of amino acid side chains that project into the groove appear to prevent peptide binding [16]. The a3 region, like its homologous domain...

Báo cáo khoa học: Akt-dependent phosphorylation negatively regulates the transcriptional activity of dHAND by inhibiting the DNA binding activity pdf

... dHAND, we next examinewhether the DNA binding activity of dHAND could beaffected by Akt phosphorylation. The in uence of phos-phorylation by Akt on the DNA binding activity wasexamined by gel shift ... phosphorylationInterestingly, major phosphorylation sites of dHAND arelocated within the bHLH domain. Therefore, we speculatedthat phosphorylation of these sites might affect the DNAbinding and/or ... lost their DNA bindingactivity. These results indicated that the phosphorylation of Thr102, Thr112, and Ser114 inhibited DNA binding activity of dHAND. In this study, we showed that Akt could bind...

Báo cáo khoa học: "Joint Learning Improves Semantic Role Labeling Kristina Toutanova Dept of Computer Science Stanford " pot

... technique for enforcing the non-overlappingconstraint discussed in Section 3.1. The labeling of the tree in Figure 1 is a speciﬁcexample of the kind of errors ﬁxed by the joint mod-els. The local classiﬁer ... to the maximum of: • The sum of the log-probabilities of the mostlikely assignments of the children subtreest1, . . . , tkplus the log-probability for assigning the node t to NONE• The ... fea-tures of labeled trees that capture general properties of predicate-argument structure.Joint Model FeaturesWe will introduce the features of the joint re-ranking model in the context of the...

Báo cáo khoa học: "Computational Lexical Semantics, Incrementality, and the So-called Punctuality of Events" potx

... distinguished in this respect" verbs like eat are capable of m-incrementality, i.e., incrementality with individual-referring delimiting arguments (they have an incremental themes in the sense of ... discussing the accessibility of the internal structure of delimiting argument NPs ; I suggested a solution to the problems raised by the polysemous internal structure of certain nouns. Finally, ... throw are only capable of i-incrementality, i.e., incrementality with collection-referring delimiting arguments (they lack an incremental theme in the sense of Dowty). Of course, non-atomicity...

Báo cáo khoa học: Tuberous sclerosis-2 (TSC2) regulates the stability of death-associated protein kinase-1 (DAPK) through a lysosome-dependent degradation pathway doc

... comprised of an N-terminal kinase domain, acalmodulin-binding domain, eight ankyrin repeats, two nucleotide binding domains (P-loops), a cytoskeleton binding domain and a C-terminaldeath domain. ... kinase-relatedapoptosis-inducing protein kinase 1) and DRAK2 [1].DAPK is a large 160 kDa serine ⁄ threonine proteinkinase composed of several functional domains includ-ing a kinase domain, a calmodulin regulatory ... microtubulenetwork. The death domain is a signalling module present in many proapoptotic proteins. The death domain of DAPK is one of the key domains central to its signallingfunction and was identiﬁed as one of...

Báo cáo khoa học: Kininogen-derived peptides for investigating the putative vasoactive properties of human cathepsins K and L docx

... explored the ability of human cath-epsins B, K and L to participate in the production of kinins,using kininogens and synthetic peptides that mimic the insertion sites of bradykinin on human kininogens.Although ... that cathepsin K is a new member of the kininase family. Both the kininogenase activity of cathepsin L and/or the kininase activity of cathepsin K maybe favored by the generation of an acidic ... regulation of kinin levels at in ammatorysites, and clearly support that cathepsin K may act as apotent kininase.Keywords: cathepsin; cysteine protease; in ammation; kinin;kininogen.Kinins, whose...

Báo cáo khoa học: "DICTIONARY ORGANIZATION FOR MACHINE TRANSLATION: THE EXPERIENCE AND IMPLICATIONS OF THEUMIST JAPANESE PROJECT" ppt

... implementation of independently motivated linguistic-theoretic descriptions. The informing principles are those of modern 'lexicalist' unification-based linguistic theories: the English ... presentation is also being refined. Foundations in linguistic theory We are committed to active recognition of the mutual benefit of machine translation and linguistic theory, and our system ... languages, and the level of abstraction appropriate to the task of translation. Firstly, what units should the entries in a machine translation dictionary system describe? In the interests of efficient...

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