... alignment of AP-2a, AP-2b, AP-2c, AP-2d, and AP-2e. The proline-rich and glutamine-rich N-terminus, which is important fortransactivation, is shown in yellow, and contains the PY-motif (green). The ... 2009 The Authors Journal compilation ê 2009 FEBS REVIEW ARTICLE Roles of AP-2 transcription factors in the regulation of cartilage and skeletal development Ann-Kathrin Wenke and Anja K. BosserhoffInstitute ... studyascribe the regulation of outgrowth of limb buds and patterning of the digits to the chicken AP-2. The role of AP-2a was further studied in zebrafish.It was confirmed that AP-2a is an essential...