Báo cáo sinh học: "Molecular machines or pleiomorphic ensembles: signaling complexes revisited" pptx

... phosphorylated but unbound to effector; and phosphorylated and bound to effector), the total potential number of states for each receptor monomer increases to 3 10 (around 60,000) and for the ... receptors in terms of exactly which sites are phosphorylated, and which effectors are bound to those sites. In reality, the activated receptor looks less like a machine and more like a pleio...

Ngày tải lên: 06/08/2014, 19:21

... developed countries. Moreover, this estimated workforce of doctors, nurs es and allied health workers in Sub-Saharan Africa consti- tutes 1.3% of the world’s health workforce, while Africa suffers ... estimates [31]. Moreover, and possibly more importantly for our policy-oriented analysis, there is the risk of excluding variables for which there is good reason to think are important, in order...

Ngày tải lên: 18/06/2014, 17:20

... factor NF-Y are imported into the nucleus by distinct pathways involving importin beta and importin 13. Mol Cell Biol 2005, , 25: 5339-5354. doi:10.1186/1479-5876-9-106 Cite this article as: Orlandi ... Tax-2 by binding the viral transactivator both directly or through a tripartite interaction with NF-YB in. CIITA is therefore a viral restriction factor for HTLV-2 and this open the possibil...

Ngày tải lên: 18/06/2014, 22:20

... and could be the cradle for CMG diversification in Africa. It also highlights the urgent need for more information. Only through building a thorough understanding of these important plant pathogens ... have had the same potential for such colo- nization. This might have been the case for EACMCV for which our data presented here suggest an old East African origin for the now widely distributed...

Ngày tải lên: 18/06/2014, 22:20

... which is common to a majority of Group II coronaviruses [25]. For an excel- lent pictorial representation of SARS-CoV genome with functions (or lack of) assigned to each ORF, please refer to the ... CDA. CJS is supported by a postdoctoral fellowship administered by the Oak Ridge Institute for Science and Education (ORISE). References 1. Zhong NS, Zeng GQ: Our strategies for fighting severe...

Ngày tải lên: 19/06/2014, 08:20

... however are too dangerous for use in human vaccines (because of the inflammatory responses they invoke), and for many vaccines adjuvants are unnecessary, because the killed organisms themselves have ... IImmpplliiccaattiioonnss ffoorr PPoolliiccyy N Engl J Med 2009, in press. 5. McKee AS, Munks MW, Marrack P: HHooww ddoo aaddjjuuvvaannttss wwoorrkk?? IImmppoorrttaanntt ccoonnssiiddeerraattii...

Ngày tải lên: 06/08/2014, 19:20

... endogenous infection or transmitting infection to health care workers and patients [3,17-23], while transient hand carriage of the organism on the hands of health care workers account for the major mechanism for ... Fritsch EF, Sambrook J: Molecular Cloning, A Laboratory Manual Volume 3. 2nd edition. Cold Spring Harbor Laboratory Press, New York; 1989. 39. Forbes BA, Schaberg DR: Transfer...

Ngày tải lên: 08/08/2014, 19:20

... opportunistic fashion or because more individuals specialized for a particular task are produced [17-20]. D ivision of labor in a super- organism ult imately relies, at least in part, on self-orga- nization ... have for the overall fitness of the t umor (for review see [54] and references therein)? Our model of solid tumors as superorganisms would predict that in the very early phase of a s...

Ngày tải lên: 18/06/2014, 19:20

... of DCs [24,25]. It has been widely reported that such maturation-resistant DCs can regulate autoreactive or alloreactive T-cell responses and promote or restore antigen-specific tolerance in experimental ... that target autoreactive T cells is an attractive strategy, with the aim of reprogramming the * Correspondence: feborras@igtp.cat † Contributed equally 1 Laboratory of Immunobiology f...

Ngày tải lên: 18/06/2014, 19:20

... PLL driven by the unfiltered correlator provided a 5 dB better performance compared with the one driven by filtered correlator. 4 Algorithm characterization 4.1 Theoretical analysis The filter used ... c where different error trajectories for initial 4 s are shown for MMSES and BJ, respectively. These trajectories show the evolution of the delay error as a function of time and for different simula...

Ngày tải lên: 18/06/2014, 22:20