Báo cáo sinh học: "Dishevelled nuclear shuttling" potx

Báo cáo sinh học: "Dishevelled nuclear shuttling" potx

... confirmed the nuclear shuttling of Dsh using drugs that block active nuclear export; these drugs led to nuclear accumulation of endoge- nous Dsh proteins in mammalian cells. “Once we had seen nuclear ... of protein localization inside the cell can be influenced by the activity of nuclear localization signals (NLS) and nuclear export signals (NES) that regulate protein shuttling in...

Ngày tải lên: 06/08/2014, 18:21

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Báo cáo sinh học: "Dishevelled and Wnt signaling: is the nucleus the final frontier" potx

... the plasma membrane or to the perinuclear /nuclear area, and the membrane localization in all cases studied requires the DEP domain [24,25]. The significance of nuclear/ perinuclear localization remained ... Dsh exhibits perinuclear localization and co- fractionates with the outer nuclear envelope. The strongest evidence for a nuclear role for Dsh comes from experiments in which nuclea...

Ngày tải lên: 06/08/2014, 18:21

4 286 0

Báo cáo sinh học: "The ribosome returned" potx

Ngày tải lên: 06/08/2014, 18:21

10 323 0

Báo cáo sinh học: "Adaptation by introgression" potx

Ngày tải lên: 06/08/2014, 19:21

3 285 0

Báo cáo sinh học: "Nuclear localization is required for Dishevelled function in Wnt/ -catenin signaling" pps

... incubated with inhibitors of nuclear export or when a specific nuclear- export signal (NES) in Dsh is disrupted by mutagenesis. Dsh protein with a mutated NES, while predominantly nuclear, remains fully ... eliminate nuclear translocation in response to NEM or LMB (Figure 4a-d), indicating that these two domains are not required for the nuclear import. Similarly, the DEP domain is not...

Ngày tải lên: 06/08/2014, 18:21

12 248 0

báo cáo sinh học:" Using nurses to identify HAART eligible patients in the Republic of Mozambique: results of a time series analysis" potx