Báo cáo sinh học: "Identifying new T -cell regulators?" potx

... the TCR pathway. Validating new components “At the end of the day, you have a list of genes that all play a role in T- cell activation,” says Payan. “The beauty of this approach is that instead ... novel proteins that might be good drug-target candidates for immune regulation and transplant rejection. This effort did in fact result in several new potential drug targets being identified....

Ngày tải lên: 06/08/2014, 18:20

... revealed that telomere length was the one biomarker that consistently corre- lated with persistence of infused T cells [51], reflecting at least in part the concept that “younger” less differen- tiated ... bioactivity Insights about product bioactivit y can often be obtained by evaluating the impact of the treatment on patient biology. A classic example of this is the delayed-type hypersens...

Ngày tải lên: 18/06/2014, 22:20

... virion proteins, the IE products activate viral genes and alter the infected cell to generate an appropriate milieu that favors viral replication [42]. Cytotoxicity assayFigure 5 Cytotoxicity assay. ... able to kill the IE1-positive autologous target cells. These data are consistent with a strong anti- gen-specific CTL response. Figure 7 shows that CTL killing activity was dose-dependent and...

Ngày tải lên: 18/06/2014, 15:20

... Restrictions in the T- cell receptor (TCR) repertoire were reported as indicator of anti-tumor cytotoxic T- lymphocyte (CTL) response in various tumor entities. It is unclear yet whether a TCR ... inter- est has moved to tumor-infiltrating T cells. CD8+ T- cell infiltration of CRC is known to be associated with a bet- ter prognosis, but it is still unknown whether these infil- trating...

Ngày tải lên: 18/06/2014, 16:20

... shown that attention to factors promoting retention is important to the long-term success of active international recruitment campaigns, which otherwise will have minimal impact beyond the short-term ... short-term view of migration and are less likely to automatically pro- vide migrants with entitlements to permanently settle. These "dramatic shifts in the destinations of migration, res...

Ngày tải lên: 18/06/2014, 17:20

... competing interests. Authors' contribution HO carried out most of the sequence analysis, contributed to the interpretation of the results, and drafted the manu- script. DR contributed to the interpretation ... binformatics methods. The conservation of the active site motifs for splicing as well as its insertion at a catalytically important site of the PolB sequence suggests that the inte...

Ngày tải lên: 18/06/2014, 22:20

... result. Results: All participants (N = 10) reported direct contact with smear-positive TB patients at baseline, during and after LTBI treatment. All participants except one started treatment with high baseline ... underwent a fol- low-up QFT-G. These students underwent a third QFT-G in July 2005, 10 months after treatment. Of the 22 stu- dents, 10 students were TST and QFT-G positive at base-...

Ngày tải lên: 20/06/2014, 00:20

... detailed phenotypic and/or functional studies to obtain more integrated data sets about the T cell product. One caveat of this methodology is that activation-induced down-modulation of the TcR ... infused into patients is a fraction of the total patient T cell load, typically no more than 0.1% of th e total. However, since most current clinical protocols that i nvolve adoptive T cell tr...

Ngày tải lên: 20/06/2014, 04:20

... screen. But if one wants to reach the goal stated at the outset - a complete inventory of the proteins that participate in a complex cellu- lar process - one cannot ignore the negatives. The highly focused ... - Tropomyosin NT - NT - NT Septin (peanut) - NT NT NT NT WASP NT - - - - + indicates that a cytokinesis or lamellar phenotype was observed; -, no phenotype was observed; NT, not tested....

Ngày tải lên: 06/08/2014, 18:20

... products of cross-fertilization. He rightly concentrated his analysis not on unit characters, but on the quantitative characters that fitted better with his concept of differential fitness, the attributes ... worked extensively on this beautiful qualitative trait, his interest was focused on the quantitative deficit of illegitimate progeny rather than the genetic control of the trait itself....

Ngày tải lên: 06/08/2014, 18:21