Báo cáo sinh học: "Identifying new T -cell regulators?" potx
Báo cáo sinh học: "Identifying new T -cell regulators?" potx
... the
TCR pathway.
Validating new components
“At the end of the day, you have a list
of genes that all play a role in T- cell
activation,” says Payan. “The beauty of
this approach is that instead ... novel proteins
that might be good drug-target candidates for immune regulation and
transplant rejection. This effort did in fact result in several new potential
drug targets being identified....
Báo cáo sinh học: " Biomarkers in T cell therapy clinical trials" potx
... revealed that telomere
length was the one biomarker that consistently corre-
lated with persistence of infused T cells [51], reflecting
at least in part the concept that “younger” less differen-
tiated ... bioactivity
Insights about product bioactivit y can often be obtained
by evaluating the impact of the treatment on patient
biology. A classic example of this is the delayed-type
hypersens...
báo cáo hóa học:" Protective CD8+ T-cell responses to cytomegalovirus driven by rAAV/GFP/IE1 loading of dendritic cells" pdf
... virion proteins, the IE products
activate viral genes and alter the infected cell to generate
an appropriate milieu that favors viral replication [42].
Cytotoxicity assayFigure 5
Cytotoxicity assay. ... able to kill the IE1-positive autologous
target cells. These data are consistent with a strong anti-
gen-specific CTL response. Figure 7 shows that CTL killing
activity was dose-dependent and...
Báo cáo hóa học: " Comparison of T-cell receptor repertoire restriction in blood and tumor tissue of colorectal cancer patients" docx
... Restrictions in the T- cell receptor (TCR)
repertoire were reported as indicator of anti-tumor cytotoxic T- lymphocyte (CTL) response in various tumor entities. It
is unclear yet whether a TCR ... inter-
est has moved to tumor-infiltrating T cells. CD8+ T- cell
infiltration of CRC is known to be associated with a bet-
ter prognosis, but it is still unknown whether these infil-
trating...
báo cáo sinh học:" "I won''''t be staying here for long": a qualitative study on the retention of migrant nurses in Ireland" ppt
... shown that attention to factors promoting
retention is important to the long-term success of active
international recruitment campaigns, which otherwise
will have minimal impact beyond the short-term ... short-term
view of migration and are less likely to automatically pro-
vide migrants with entitlements to permanently settle.
These "dramatic shifts in the destinations of migration,
res...
Báo cáo sinh học: " A new example of viral intein in Mimivirus" ppt
... competing
interests.
Authors' contribution
HO carried out most of the sequence analysis, contributed
to the interpretation of the results, and drafted the manu-
script. DR contributed to the interpretation ... binformatics methods. The conservation of the
active site motifs for splicing as well as its insertion at a
catalytically important site of the PolB sequence suggests
that the inte...
báo cáo hóa học: " Persistently elevated T cell interferon-γ responses after treatment for latent tuberculosis infection among health care workers in India: a preliminary report" pot
... result.
Results: All participants (N = 10) reported direct contact with smear-positive TB patients at baseline, during and after
LTBI treatment. All participants except one started treatment with high baseline ... underwent a fol-
low-up QFT-G. These students underwent a third QFT-G
in July 2005, 10 months after treatment. Of the 22 stu-
dents, 10 students were TST and QFT-G positive at base-...
báo cáo hóa học:" Biomarkers in T cell therapy clinical trials" docx
... detailed phenotypic and/or functional
studies to obtain more integrated data sets about the T
cell product. One caveat of this methodology is that
activation-induced down-modulation of the TcR ... infused
into patients is a fraction of the total patient T cell load,
typically no more than 0.1% of th e total. However, since
most current clinical protocols that i nvolve adoptive T
cell tr...
Báo cáo sinh học: "Functional genomics of cell morphology using RNA interference: pick your style, broad or deep" doc
... screen. But if one
wants to reach the goal stated at the outset - a complete
inventory of the proteins that participate in a complex cellu-
lar process - one cannot ignore the negatives. The highly
focused ... -
Tropomyosin NT - NT - NT
Septin (peanut) - NT NT NT NT
WASP NT - - - -
+ indicates that a cytokinesis or lamellar phenotype was observed; -, no phenotype was observed; NT, not tested....
Báo cáo sinh học: " Why didn’t Darwin discover Mendel’s laws" pdf
... products of cross-fertilization. He rightly concentrated
his analysis not on unit characters, but on the quantitative
characters that fitted better with his concept of differential
fitness, the attributes ... worked extensively on this beautiful
qualitative trait, his interest was focused on the quantitative deficit of illegitimate progeny rather than the genetic control of the trait itself....