... semen, potentlyinhibit amyloid formation by apoC -II. Inhibition isdependent on apoC -II concentration, with more effectiveinhibition by clusterin observed at lower concentrations ofapoC -II. The ... AustraliaThe effect of the extracellular chaperone, clusterin, onamyloid fibril formation by lipid-free human apolipoprotein C- II (apoC -II) was investigated. Sub-stoichiometric levels ofclusterin, ... coefficient of apoC -II fibrils formed from apoC -II (0.3 mgÆmL)1) is reduced bycoincubation with clusterin (10 lgÆmL)1). In contrast,addition of clusterin (0.1 mgÆmL)1) to preformed apoC -II amyloid...