The Biological Sample Classification Using Gene Expression Data

... data. The quality of gene expression data strongly depends on the equiments used, the biological variation and the measurement condition. Therefore, the gene expression data must be pre-processed ... Moreover, the gene expression level is also regulated by the products of other genes. This means that there exists a gene regulatory network by which a gene...

Ngày tải lên: 01/08/2014, 17:47

... gene expression levels. The gene expression profiles show considerable coherence, in that cells clustered on the basis of their expression profiles for 1,376 genes and 40 targets tend to sort themselves ... gene and a drug by taking the (normalized) level of expression of the gene in each cell line, multiplying it by the corresponding (nor- malized) sensitivity of the...

Ngày tải lên: 30/03/2014, 13:20

... it extracts the localized high-frequency details of the expression signal. When the wavelet is fully diluted, the length of the wavelet is more comparable to the length of the gene expression ... and the calculated CWT coefficients refer to the closeness of the gene expression profile to the wavelet at the current scale. The flexible approach uses a scalable wi...

Ngày tải lên: 22/06/2014, 19:20

... Heatmap of smoothed gene expression profiles for the whole dataset. Genes are ordered according to their cluster deter- mined by the k-means algorithm. Horizontal blue lines separate the 4 clusters. ... profiles themselves. When color coding the profiles themselves, the eye needs to integ rate the changes of colors along the ordered time points to extract the direction and t...

Ngày tải lên: 22/06/2014, 19:20

... to the clusters in the models than the LMC and the hierarchic clus- tering methods. 3.2. An application to microarray gene expression data Application of the LMC method to gene expression data ... clustered. The local maximum of a data point i is the data point whose magnitude is the maximum among all the data points within a certain distance from the da...

Ngày tải lên: 23/06/2014, 01:20

... ABPs transduced the changes in cell structure that occur dur- ing morphogenesis to the nucleus, resulting in changes in gene expression via either the nuclear shuttling of transcription factors or the assembly ... liganded AR to the nucleus. In the nucleus, FLNa(16–24) disrupts interactions between the N- and C-termini of the AR, and interferes with the binding of the...

Ngày tải lên: 07/03/2014, 01:20

... tract. Typically, data sets are only coded with the census tracts of the most recent census data set. In the case of the PSID, for instance, data from the 1970s contained information using 1970 census ... containers in the streets; rating of most of the housing units in the face block; and general rating of the condition of the street. There are also logistical...

Ngày tải lên: 22/03/2014, 14:20

... parameter was the maximum value over the number of trials. The third and fourth criteria made use of the Silhouette statistic, one using the clusters of transformed data and one using the corresponding ... would place these two sequences in different clusters. By transforming the data, the similarity of the two sequences is enhanced, and the clustering algorithm can...

Ngày tải lên: 22/06/2014, 00:20

... on original data 14 — — SSM on undersampled data —33 SSM on interpolated data —42 CoD on original data 12 — — CoD on undersampled data —32 CoD on interpolated data —42 on whether these frameworks ... the first two regimes for the genes coclustered in these regimes. To clarify the validity of the presented approach, we present a similar analysis on another data set the T-...

Ngày tải lên: 22/06/2014, 19:20