... structure of MGD1, only the looppart seems to convey activity. Activity is directed mainly against Gram-positive bacteriaand fungiThe activity spectra of peptides B, K, M and Q werecompared ... theloop 3 sequence and its bacteriostatic activity is inagreement with the general observation that the basicityof defensins is an important parameter for activity, inparticular because it is ... antifungal activity. J. Biol. Chem. 272,1171–1179.36. Thennarasu, S. & Nagaraj, R. (1999) Synthetic peptides corre-sponding to the beta-hairpin loop of rabbit defensin NP-2 showantimicrobial activity. ...