... opposing roles, mainly the apoptotic TAisoform(s) and the antiapoptotic DM isoforms. In gen-eral, TAp73 isoforms regulate the transcription of DMp73 isoforms, which, in turn, act as dominant ... difference in the C-termi-nal domain of TAp73c is that, owing to the excision of exon 11 during alternative splicing, it lacks most of the Glu ⁄ Pro-rich domain and the Pro-rich domain,which ... than the overexpression of a specific p73 isoform or a specificclass of p73 isoforms per se [20,21]. In line with this concept, the selective promoter acti-vation could result in the activation of...