... Several of these drugs are currently in Phase I trials as single agentsor in combination with chemotherapy. [7-11] A criticalaspect in the design of these trials has been the selection of appropriate ... coordination, supervised the analysis and interpretation of the data, and writing the manuscript. All authors read and approved the final man-uscript.Acknowledgements The authors would like to acknowledge ... limits of the boxes indicating the 75thand 25th percentiles, respectively, and the central, hori-zontal line representing the median. Outliers are valuesthat are more than 1.5 times the inter-quartile...