Chapter 136 Meningococcal Infections (Part 6) docx

... endocarditis. Figure 136- 4 Chapter 136. Meningococcal Infections (Part 6) Clinical Manifestations Upper Respiratory Tract Infections Although many patients who develop meningococcal meningitis ... Chap. 3 76) Common presenting symptoms of patients with meningococcal meningitis include nausea and vomiting, headache, neck stiffness, lethargy, and confusion. The sy...

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... epidemics of serogroup W-135 meningococcal disease occurred in association with the Muslim pilgrimage to Mecca (the Hajj) and in the meningitis belt of sub-Saharan Africa. meningococcal strains ... all, 300,000– 500,000 cases of meningococcal disease occur worldwide each year—numbers that frequently are increased by large epidemics. The annual incidence of meningococcal disease i...

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... Chapter 136. Meningococcal Infections (Part 2) In the United States, the attack rate for sporadic meningococcal disease is ~1 case per 100,000 ... pathogenesis. Figure 136- 1 Meningococcal disease pathogenesis, susceptibility, and severity. After human-to-human transmission, environmental factors (smoking, co- infections) , polymorphisms ... adults (<1 case p...

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... for this serogroup. Outer-Membrane Proteins Chapter 136. Meningococcal Infections (Part 3) Outer-Membrane Components Associated with Virulence Meningococcal strains are characterized by the ... properties promote meningococcal transmission, spread, and survival externally and within intracellular compartments such as phagocytic vacuoles. Except in serogroup A, the major...

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... Meningitis Chapter 136. Meningococcal Infections (Part 4) Association of Virulence Mechanisms with Specific Meningococcal Infections Specific disease manifestations of meningococcal infections ... potential site of meningococcal entry into the CSF. Meningococcal pili may bind CD46, a complement-regulatory protein that is expressed by the choroid plexus and menin...

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... acquiring meningococcal disease in childhood. Alleles that decrease MBL synthesis have been associated with increased risk in the few studies reported to date. Chapter 136. Meningococcal Infections ... meningococcal disease. This conclusion is supported by the overrepresentation of ABO blood group nonsecretors among patients with meningococcal disease and by the striking varia...

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... immunity (decreased transmission and colonization). Chapter 136. Meningococcal Infections (Part 7) Complications Patients with meningococcal meningitis may develop cranial nerve palsies, ... 52-4), endemic typhus, and some viral infections. In one case series, one- Table 136- 1 Antibiotic Treatment, Chemoprophylaxis, and Vaccinations for Invasive Meningococcal Disease...

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... and in family members of patients found to have a complement deficiency. Chapter 136. Meningococcal Infections (Part 8) Patients with fulminant meningococcemia often experience diffuse ... disease in the population vaccinated. If conjugate meningococcal vaccines prove to be capable of providing durable antibody or memory responses (particularly in infants and young childre...

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... genes.' BMC Genomics 7:128, 2006 [PMID: 16734888] Chapter 136. Meningococcal Infections (Part 9) Antimicrobial Chemoprophylaxis The attack rate for meningococcal disease among household or other ... 9472667] Rosenstein NE et al: Meningococcal disease. N Engl J Med 344:1378, 2001 [PMID: 11333996] Westendorp RGJ et al: Genetic influence on cytokine production and fat...

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... update of the prospective multicentric SEMPET trial. J Clin Oncol 22:1034, 2004 Chapter 092. Testicular Cancer (Part 6) Fertility Infertility is an important consequence of the treatment of

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