Chapter 136. Meningococcal Infections (Part 2) ppsx

... significant weight loss (Chap. 71). Causes of Weight Loss The list of possible causes of weight loss is extensive (Table 41-1). In the elderly, the most common causes of weight loss are depression, ... present with weight loss and weakness, with few other manifestations of thyrotoxicosis. New-onset diabetes mellitus is often accompanied by weight loss, reflecting g...

Ngày tải lên: 06/07/2014, 15:21

... Chapter 076. Eating Disorders (Part 2) Table 76- 1 Common Characteristics of Anorexia Nervosa and Bulimia Nervosa ... in women Weight Markedly decreased Usually normal Menstruation Absent Usually normal Binge eating 25–50% Required for diagnosis Mortality 5% per decade Low Physical and Laboratory Findings a ... Low-normal thyroxine Normal TSH Increased cortiso...

Ngày tải lên: 07/07/2014, 01:20

... epidemics of serogroup W-135 meningococcal disease occurred in association with the Muslim pilgrimage to Mecca (the Hajj) and in the meningitis belt of sub-Saharan Africa. meningococcal strains ... all, 300,000– 500,000 cases of meningococcal disease occur worldwide each year—numbers that frequently are increased by large epidemics. The annual incidence of meningococcal disease i...

Ngày tải lên: 08/07/2014, 02:20

... Chapter 136. Meningococcal Infections (Part 2) In the United States, the attack rate for sporadic meningococcal disease is ~1 case per 100,000 ... pathogenesis. Figure 136-1 Meningococcal disease pathogenesis, susceptibility, and severity. After human-to-human transmission, environmental factors (smoking, co- infections) , polymorphisms ... adults (<1 case...

Ngày tải lên: 08/07/2014, 02:20

... for this serogroup. Outer-Membrane Proteins Chapter 136. Meningococcal Infections (Part 3) Outer-Membrane Components Associated with Virulence Meningococcal strains are characterized by the ... properties promote meningococcal transmission, spread, and survival externally and within intracellular compartments such as phagocytic vacuoles. Except in serogroup A, the majo...

Ngày tải lên: 08/07/2014, 02:20

... Meningitis Chapter 136. Meningococcal Infections (Part 4) Association of Virulence Mechanisms with Specific Meningococcal Infections Specific disease manifestations of meningococcal infections ... potential site of meningococcal entry into the CSF. Meningococcal pili may bind CD46, a complement-regulatory protein that is expressed by the choroid plexus and me...

Ngày tải lên: 08/07/2014, 02:20

... acquiring meningococcal disease in childhood. Alleles that decrease MBL synthesis have been associated with increased risk in the few studies reported to date. Chapter 136. Meningococcal Infections ... meningococcal disease. This conclusion is supported by the overrepresentation of ABO blood group nonsecretors among patients with meningococcal disease and by the striking vari...

Ngày tải lên: 08/07/2014, 02:20

... endocarditis. Figure 136-4 Chapter 136. Meningococcal Infections (Part 6) Clinical Manifestations Upper Respiratory Tract Infections Although many patients who develop meningococcal meningitis ... Chap. 3 76) Common presenting symptoms of patients with meningococcal meningitis include nausea and vomiting, headache, neck stiffness, lethargy, and confusion. The sym...

Ngày tải lên: 08/07/2014, 02:20

... immunity (decreased transmission and colonization). Chapter 136. Meningococcal Infections (Part 7) Complications Patients with meningococcal meningitis may develop cranial nerve palsies, ... clinical clues help the physician distinguish the patient with early meningococcal disease from patients with other acute systemic infections. The most useful clinical finding is...

Ngày tải lên: 08/07/2014, 02:20

... in family members of patients found to have a complement deficiency. Chapter 136. Meningococcal Infections (Part 8) Patients with fulminant meningococcemia often experience diffuse leakage ... disease in the population vaccinated. If conjugate meningococcal vaccines prove to be capable of providing durable antibody or memory responses (particularly in infants and young...

Ngày tải lên: 08/07/2014, 02:20

... genes.' BMC Genomics 7:128, 2006 [PMID: 16734888] Chapter 136. Meningococcal Infections (Part 9) Antimicrobial Chemoprophylaxis The attack rate for meningococcal disease among household or other ... 9472667] Rosenstein NE et al: Meningococcal disease. N Engl J Med 344:1378, 2001 [PMID: 11333996] Westendorp RGJ et al: Genetic influence on cytokine production and...

Ngày tải lên: 08/07/2014, 02:20

... as well as CD8+ T lymphocytes is seen in individuals Chapter 137. Gonococcal Infections (Part 2) Opacity-Associated Protein Another gonococcal surface protein that is important in adherence ... against neisserial infections is best illustrated by the predisposition of persons deficient in terminal complement components (C5 through C9) to recurrent bacteremic gonococcal...

Ngày tải lên: 08/07/2014, 02:20

... Chapter 138. Moraxella Infections (Part 2) Other Syndromes Local extension causing empyema is very uncommon, and—as ... coagulation, has been described in a few cases. Diagnosis Table 138-1 Therapy for Infection Caused by Moraxella Catarrhalis Drug(s) Dose and Duration Oral Therapy for Lower Respiratory Infection a

Ngày tải lên: 08/07/2014, 02:20

... of bacteremia due to Moraxella catarrhalis . Clin Infect Dis 21:390, 1995 [PMID: 8562749] Chapter 138. Moraxella Infections (Part 3) Other Moraxella Species Other Moraxella species are ... Moraxella lincolnii . Note: CSF, cerebrospinal fluid. Source: Adapted from a summary of CDC experience (Graham et al). Further Readings Graham DR et al: Infections caused b...

Ngày tải lên: 08/07/2014, 02:20

... circulation; in the absence of antibody, however, only the slow passage of blood Chapter 128. Pneumococcal Infections (Part 2) Nonimmunologic Mechanisms Nonimmunologic mechanisms that protect against ... pneumococcal infection is greatly increased in persons with conditions that compromise IgG synthesis and/or the phagocytic function of PMNs and macrophages. Most patien...

Ngày tải lên: 08/07/2014, 02:20