Chapter 126 Infections in Transplant Recipients (Part 7) docx
Chapter 126. Infections in Transplant Recipients (Part 7) docx
... and lung transplants—who receive the most intensive immunosuppressive regimens—are most likely to develop EBV-LPD, particularly Chapter 126. Infections in Transplant Recipients (Part 7) Adenovirus ... therapy (when indicated), and rapid diagnosis and treatment of infections can be lifesaving in SOT recipients, who, unlike most HSCT recipients, continue to be immunosuppressed. SOT recipients ... (Chap. 1 77). Intranasal pleconaril, a capsid-binding agent, is being studied for the treatment of enterovirus infection. Rhinoviruses and coronaviruses are frequent co-pathogens in HSCT recipients; ...
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Chapter 126. Infections in Transplant Recipients (Part 14) docx
... vaccines (Chaps. 116 and 1 17). In general, these patients should receive any killed or inactivated vaccine preparation appropriate to the area they are visiting; Chapter 126. Infections in Transplant ... Transplant Recipients (Part 14) In the absence of compelling data as to optimal timing, it is reasonable to administer the pneumococcal and H. influenzae type b conjugate vaccines to both ... P et al: Mycobacterium tuberculosis infection in recipients of solid organ transplants. Clin Infect Dis 40:581, 2005 [PMID: 15712081] Zerr DM et al: Clinical outcomes of human herpesvirus...
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Chapter 126. Infections in Transplant Recipients (Part 1) pdf
... Internal Medicine > Chapter 126. Infections in Transplant Recipients Infections in Transplant Recipients: Introduction The evaluation of infections in transplant recipients involves consideration ... corneal transplants. eT. gondii usually causes disease in the brain. In hematopoietic stem cell Chapter 126. Infections in Transplant Recipients (Part 1) Harrison's Internal Medicine ... recipient of the transplanted organ. Infections following transplantation are complicated by the use of drugs that are necessary to enhance the likelihood of survival of the transplanted organ...
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Chapter 126. Infections in Transplant Recipients (Part 2) potx
... varicella-zoster virus. Chapter 126. Infections in Transplant Recipients (Part 2) In many transplantation centers, transmission of infections that may be latent or clinically inapparent in the donor ... latent infections already. Nevertheless, most infections occur in a predictable time frame after transplantation (Table 126- 2). Table 126- 2 Common Sources of Infections after Hematopoietic ... and Trypanosoma cruzi (the latter particularly in Latin America). Clinicians caring for prospective organ donors should also consider assessing stool for parasites, should ...
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Chapter 126. Infections in Transplant Recipients (Part 4) ppsx
... available. Promising new drugs that are now being assessed in clinical trials include maribavir, a benzimidazole ribonucleoside that inhibits a viral protein kinase activity (UL 97). esophagitis. ... ulcerations occur in both the lower and the upper gastrointestinal tract, and it may be difficult to distinguish diarrhea due to GVHD from that due to CMV infection. The finding of CMV in the liver ... abnormalities. It is interesting that the ocular and neurologic manifestations of CMV infections are uncommon in these patients. Management of CMV disease in HSCT recipients includes strategies...
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Chapter 126. Infections in Transplant Recipients (Part 5) potx
... Chapter 126. Infections in Transplant Recipients (Part 5) Like prophylaxis, preemptive treatment, which targets patients with polymerase chain reaction (PCR) evidence ... disease. Treatment of CMV pneumonia in HSCT recipients (unlike that in other clinical settings) involves both IV immune globulin (IVIg) and ganciclovir. In patients who cannot tolerate ganciclovir, ... antibodies to T cells). Although less likely in autologous transplantation, reactivation can occur in T cell–depleted autologous recipients (e.g., patients being given antibodies to T cells for the...
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Chapter 126. Infections in Transplant Recipients (Part 6) ppsx
... KSHV in the Chapter 126. Infections in Transplant Recipients (Part 6) PCR can be used to monitor EBV production after hematopoietic stem cell transplantation. High or increasing viral loads ... critical in an assessment of posttransplantation infections. to have activity against the different forms of latent EBV infection. Preventing lytic replication in these patients would theoretically ... resulted in disease in HSCT recipients, although some cases of virus-associated marrow aplasia have been reported in the peritransplantation period. The relatively low seroprevalence of KSHV in the...
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Chapter 126. Infections in Transplant Recipients (Part 8) potx
... Chapter 126. Infections in Transplant Recipients (Part 8) Kidney Transplantation (See Table 126- 4) Table 126- 4 Common Infections after Kidney Transplantation Period after Transplantation ... Nocardia; invasive fungi Central nervous system Listeria (meningitis); Toxoplasma gondii CMV disease; Listeria (meningitis); Cryptococcus (meningitis); Table 126- 5 Prophylaxis of Infections ... chest imaging and/or no previous treatment Chest imaging; PPD and/or cell-based assay aSerologic examination, PPD testing, and interferon assays may be less reliable after transplantation....
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Chapter 126. Infections in Transplant Recipients (Part 9) pot
... Chapter 126. Infections in Transplant Recipients (Part 9) Middle-Period Infections Because of continuing immunosuppression, kidney transplant recipients are predisposed to lung infections ... Legionella pneumophila infection (Chap. 141) led to the closing of renal transplant units in hospitals with endemic legionellosis. About 50% of all renal transplant recipients presenting with fever ... JC virus (polyomavirus hominis types 1 and 2) have been cultured from the urine of kidney transplant recipients (as they have from that of HSCT recipients) in the setting of profound immunosuppression....
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Chapter 126. Infections in Transplant Recipients (Part 10) pdf
... Chapter 126. Infections in Transplant Recipients (Part 10) Kidney transplant recipients are also subject to infections with other intracellular organisms. These ... cause pulmonary infiltrates or disseminated disease. Late Infections Late infections (>6 months after kidney transplantation) may involve the CNS and include CMV retinitis as well as ... hominis infection is suspected. M. hominis mediastinitis has been cured with a combination of surgical debridement (sometimes requiring muscle-flap placement) and the administration of clindamycin...
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