Hepatocellular Carcinoma: Targeted Therapy and Multidisciplinary P39 pptx

... irinotecan- based chemotherapy and bevacizumab to 5-fluorouracil-based chemotherapy sub- stantially prolonged patient survival in multiple studies [30–35]. Following the success of combination cytotoxic and biologic ... ligand, has been investigated in Phase II studies alone or in combination with other agents. Chapter 23 The Future: Combination Systemic Therapy for Hepatocellular Carc...

Ngày tải lên: 07/07/2014, 09:20

... completely noninvasive. Although both the ribs and the air in the lungs and gastrointestinal tract surround the liver and potentially hinder imaging, newer ultrasound devices and techniques have improved hepatic ... elderly population [56]. New Serum Markers and New Methods Recent developments in gene-expression microarrays, proteomics, and tumor immunology now permit thousands of...

Ngày tải lên: 07/07/2014, 09:20

... ablation and percutaneous microwave coagulation therapy. Radiology 223:331–337 7. Lu MD, Chen JW, Xie XY et al (2001) Hepatocellular carcinoma: US-guided percutaneous microwave coagulation therapy. ... ablation: proposal for standardization of terms and reporting criteria. Radiology 228:335–345 10. Diederich CJ (2005) Thermal ablation and high-temperature thermal therapy: overvie...

Ngày tải lên: 07/07/2014, 09:20

... Grades 3 and 4 skin toxicity and diarrhea were the most notable adverse Chapter 22 Targeted Therapies for Hepatocellular Carcinoma Jonas W. Feilchenfeldt, Eileen M. O’Reilly, Costantine Albany, and ... CI, 7.5–11.7). Grades 3 and 4 adverse events included elevated SGOT (18%); lymphopenia (15%); neutropenia, thrombo- cytopenia, and fatigue (12%); elevated SGPT (9%); and hand-fo...

Ngày tải lên: 07/07/2014, 09:20

... 372t Treatment algorithm for HCC (Japan), 90f advanced cancer chemotherapy, 93 TACE and liver resection, 93 degree of liver damage A and B liver resection/percutaneous ablation treatment, two/three ... 114 postoperative mortality, 114 M.D. Anderson Cancer Center, criteria for resection, 110t patient selection/preparation, 110 preoperative therapy chemotherapy, 118–120 PVE, perioperative...

Ngày tải lên: 07/07/2014, 09:20

... both environmental and chronic medical conditions. These emerging factors, such as v Kelly M. McMasters Jean-Nicolas Vauthey Editors Hepatocellular Carcinoma Targeted Therapy and Multidisciplinary ... Texas January 2010 vii Foreword It is a great pleasure and an honor to write the preface for this outstanding book dedicated to the therapy of hepatocellular carcinoma (HCC). T...

Ngày tải lên: 07/07/2014, 09:20

... Pritesh Mutha, and Sanjay Gupta 21 Cytotoxic Chemotherapy and Endocrine Therapy for Hepatocellular Carcinoma 337 Daniel Palmer and Philip J. Johnson 22 Targeted Therapies for Hepatocellular Carcinoma ... Albany, and Ghassan K. Abou-Alfa 23 The Future: Combination Systemic Therapy for Hepatocellular Carcinoma 369 Ahmed O. Kaseb and Melanie B. Thomas 24 Follow-Up and Sal...

Ngày tải lên: 07/07/2014, 09:20

... calcula- tion and definition of obesity. Results from an ongoing case–control s tudy indicated 1 Epidemiology and Pathogenesis of Hepatocellular Carcinoma 13 6. El-Serag HB, Rudolph KL (2007) Hepatocellular ... compounds: B 1 ,B 2 ,G 1 , and G 2 [55]. The most common and most toxic AF is AFB 1 , and the most important target organ is the liver, where the toxicity can lead to live...

Ngày tải lên: 07/07/2014, 09:20

... of alcohol, diabetes, and viral hepatitis on the risk of hepatocellular carcinoma in blacks and whites in the U.S. Cancer 101:1009–1017 1 Epidemiology and Pathogenesis of Hepatocellular Carcinoma ... genes and miRNAs in biological pathways. Furthermore, signif- icant and complex cross talks among the different pathways exist and are involved in different aspects of HCC develop...

Ngày tải lên: 07/07/2014, 09:20

... Bianchi L (1993) Glycogen storage disease I and hepatocellular tumours. Eur J Pediatr 152(Suppl 1):S63–S70 54. Kowdley KV (2004) Iron, hemochromatosis, and hepatocellular carcinoma. Gastroenterology 127:S79–S86 55. ... Ohshima S, Goto T, et al (2007) Non-alcoholic steatohepatitis and hepatocellular carcinoma: lessons from hepatocyte-specific phosphatase and tensin homolog (PTEN...

Ngày tải lên: 07/07/2014, 09:20