Chapter 104 Acute and Chronic Myeloid Leukemia (Part 9) pptx
Chapter 104. Acute and Chronic Myeloid Leukemia (Part 9) pptx
...
Radiolabeled antibodies
Yttrium-90-labeled human M195
Chapter 104. Acute and Chronic
Myeloid Leukemia
(Part 9)
Treatment of Promyelocytic Leukemia
Tretinoin is an oral drug that induces the ... cytarabine is more effective than standard-dose cytarabine. The Cancer and
Leukemia Group B (CALGB), for example, compared the duration of CR in
patients randomly a...
Chapter 104. Acute and Chronic Myeloid Leukemia (Part 13) pptx
... or reduced intensity); (4) GVHD; and (5)
posttransplantation treatment.
Chapter 104. Acute and Chronic
Myeloid Leukemia
(Part 13)
Chronic Myelogenous Leukemia: Treatment
The therapy of ...
d
Complete
hematologic remission, WBC <10,000/µL, normal blood
morphology, hemoglobin and platelet counts, and disappearance of splenomegaly.
e
Minor cytogenetic remiss...
Chapter 104. Acute and Chronic Myeloid Leukemia (Part 16) pptx
... 2007.
http://www.nccn.org/professionals/physician_gls/PDF/cml.pdf
Chapter 104. Acute and Chronic
Myeloid Leukemia
(Part 16)
Interferon
Before imatinib, when allogeneic SCT was not feasible, ... al: Genetics of myeloid malignancies: Pathogenetic and
clinical implications. J Clin Oncol 23:6285, 2005 [PMID: 16155011]
National Comprehensive Cancer Network: Acute...
Chapter 104. Acute and Chronic Myeloid Leukemia (Part 1) ppsx
... the past by the Food and Drug
Administration (FDA) for marketing based on trials using the FAB criteria.
Acute Myeloid Leukemia
Incidence
The incidence of acute myeloid leukemia (AML) is ~3.7 ... years after exposure,
and affected individuals have aberrations in chromosomes 5 and 7. Topoisomerase
II inhibitor–associated leukemias occur 1–3 years after exposure, and a...
Chapter 104. Acute and Chronic Myeloid Leukemia (Part 2) pot
... Acute myelomonocytic leukemia
Acute monoblastic and monocytic leukemia
Acute erythroid leukemia
Acute megakaryoblastic leukemia
Acute basophilic leukemia
Acute panmyelosis ... myelofibrosis
Myeloid sarcoma
French-American-British (FAB) Classification
c
Incidence
M0: Minimally differentiated leukemia 5%
M1: Myeloblastic leukemia without maturation 20%
M2: Mye...
Chapter 104. Acute and Chronic Myeloid Leukemia (Part 3) pps
... Continuous
activation of Flt3 and downstream target kinases, including signal transducer and
Chapter 104. Acute and Chronic
Myeloid Leukemia
(Part 3)
Immunophenotype and Relevance to the WHO ... associated with younger age are t(8;21) and t(l5;17); with older
age, del(5q) and del(7q). Myeloid sarcomas (see below) are associated with t(8;21)
and disseminated...
Chapter 104. Acute and Chronic Myeloid Leukemia (Part 4) pps
... morphologically by abnormal
lobulation and deficient granulation.
Figure 104- 1
Chapter 104. Acute and Chronic
Myeloid Leukemia
(Part 4)
Clinical Presentation
Symptoms
Patients with AML most ... they are,
myeloid lineage is virtually certain (Fig 104- 1). Poor neutrophil function may be
noted by impaired phagocytosis and migration and morphologically by ab...
Chapter 104. Acute and Chronic Myeloid Leukemia (Part 5) docx
... Chapter 104. Acute and Chronic
Myeloid Leukemia
(Part 5)
Morphology of AML cells. A. Uniform population of primitive
myeloblasts with immature chromatin, nucleoli in some cells, and ...
Ecchymosis and oozing from I
V sites (DIC, possible acute promyelocytic
leukemia)
Fever and tachycardia (signs of infection)
Papilledema, retinal infiltrates, cranial nerve abn...
Chapter 104. Acute and Chronic Myeloid Leukemia (Part 6) pps
... achievement of CR. In addition, patients who achieve
Chapter 104. Acute and Chronic
Myeloid Leukemia
(Part 6)
Most patients are anemic and thrombocytopenic at presentation.
Replacement of ... t(6 ;9),
inv(3), or 7 have a very poor prognosis. This emphasizes the importance of
cytogenetic as well as the previously discussed molecular assessment of the
leukemia cells a...
Chapter 104. Acute and Chronic Myeloid Leukemia (Part 7) pot
... Chapter 104. Acute and Chronic
Myeloid Leukemia
(Part 7)
Acute Myeloid Leukemia: Treatment
Treatment of the newly diagnosed patient ... allogeneic stem cell
Figure 104- 2
Flow chart for the therapy of newly diagnosed acute myeloid leukemia.
For all forms of AML except acute promyelocytic leukemia (APL), standard
therapy includes ...
synthesis and...
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