Chapter 104 Acute and Chronic Myeloid Leukemia (Part 3) pps

... Continuous activation of Flt3 and downstream target kinases, including signal transducer and Chapter 104. Acute and Chronic Myeloid Leukemia (Part 3) Immunophenotype and Relevance to the WHO ... associated with younger age are t(8;21) and t(l5;17); with older age, del(5q) and del(7q). Myeloid sarcomas (see below) are associated with t(8;21) and disseminat...

Ngày tải lên: 07/07/2014, 04:20

... the past by the Food and Drug Administration (FDA) for marketing based on trials using the FAB criteria. Acute Myeloid Leukemia Incidence The incidence of acute myeloid leukemia (AML) is ~3.7 ... years after exposure, and affected individuals have aberrations in chromosomes 5 and 7. Topoisomerase II inhibitor–associated leukemias occur 1–3 years after exposure, and a...

Ngày tải lên: 07/07/2014, 04:20

... morphologically by abnormal lobulation and deficient granulation. Figure 104- 1 Chapter 104. Acute and Chronic Myeloid Leukemia (Part 4) Clinical Presentation Symptoms Patients with AML most ... they are, myeloid lineage is virtually certain (Fig 104- 1). Poor neutrophil function may be noted by impaired phagocytosis and migration and morphologically by ab...

Ngày tải lên: 07/07/2014, 04:20

... achievement of CR. In addition, patients who achieve Chapter 104. Acute and Chronic Myeloid Leukemia (Part 6) Most patients are anemic and thrombocytopenic at presentation. Replacement of ... t(6;9), inv (3), or 7 have a very poor prognosis. This emphasizes the importance of cytogenetic as well as the previously discussed molecular assessment of the leukemia cells a...

Ngày tải lên: 07/07/2014, 04:20

... Chapter 104. Acute and Chronic Myeloid Leukemia (Part 11) Chronic Myelogenous Leukemia Incidence The incidence of chronic myelogenous leukemia (CML) is 1.5 per ... transition from a chronic phase to an accelerated phase and on to blast crisis in a median time of 4 years. Etiology No clear correlation with exposure to cytotoxic drugs has been found, and...

Ngày tải lên: 07/07/2014, 04:20

... Acute myelomonocytic leukemia Acute monoblastic and monocytic leukemia Acute erythroid leukemia Acute megakaryoblastic leukemia Acute basophilic leukemia Acute panmyelosis ... myelofibrosis Myeloid sarcoma French-American-British (FAB) Classification c Incidence M0: Minimally differentiated leukemia 5% M1: Myeloblastic leukemia without maturation 20% M2: Mye...

Ngày tải lên: 07/07/2014, 04:20

... Chapter 104. Acute and Chronic Myeloid Leukemia (Part 5) Morphology of AML cells. A. Uniform population of primitive myeloblasts with immature chromatin, nucleoli in some cells, and ... Ecchymosis and oozing from I V sites (DIC, possible acute promyelocytic leukemia) Fever and tachycardia (signs of infection) Papilledema, retinal infiltrates, cranial nerve abn...

Ngày tải lên: 07/07/2014, 04:20

... Chapter 104. Acute and Chronic Myeloid Leukemia (Part 7) Acute Myeloid Leukemia: Treatment Treatment of the newly diagnosed patient ... allogeneic stem cell Figure 104- 2 Flow chart for the therapy of newly diagnosed acute myeloid leukemia. For all forms of AML except acute promyelocytic leukemia (APL), standard therapy includes ... synthesis and...

Ngày tải lên: 07/07/2014, 04:20

... Chapter 104. Acute and Chronic Myeloid Leukemia (Part 8) The hematologic toxicity of high-dose cytarabine-based induction ... been greater than that associated with 7 and 3 regimens. Toxicity with high-dose cytarabine includes myelosuppression, pulmonary toxicity, and significant and occasionally irreversible cerebellar ... each dose, and further high-dose cytar...

Ngày tải lên: 07/07/2014, 04:20

... (SGN 33), anti-DR4, anti- DR5, anti-KiR Toxin-conjugated antibodies Gemtuzumab ozogamicin (Mylotarg) Radiolabeled antibodies Yttrium-90-labeled human M195 Chapter 104. Acute and Chronic ... cytarabine is more effective than standard-dose cytarabine. The Cancer and Leukemia Group B (CALGB), for example, compared the duration of CR in patients randomly assigned postremi...

Ngày tải lên: 07/07/2014, 04:20